Results 21 to 30 of about 12,681 (186)

Human P2Y11 Expression Level Affects Human P2X7 Receptor-Mediated Cell Death

Frontiers in Immunology, 2018
Adenosine triphosphate (ATP) is known to induce cell death in T lymphocytes at high extracellular concentrations. CD4+ and CD8+ T lymphocytes have a differential response to ATP, which in mice is due to differences in the P2X7 receptor expression levels.
Karin Dreisig, Louise Sund, Maja Wallentin Dommer, Nikolaj Pagh Kristensen, Kim Boddum, Rannveig Viste, Simon Fredholm, Niels Odum, Marja Jäättelä, Søren Skov, Birgitte R. Kornum, Birgitte R. Kornum   +11 more
doaj   +1 more source

P2X7 Receptor Induces Tumor Necrosis Factor-α Converting Enzyme Activation and Release to Boost TNF-α Production

Frontiers in Immunology, 2017
Tumor necrosis factor (TNF)-α is a major pro-inflammatory cytokine produced in response to toll-like receptor stimulation. TNF-α release is controlled by the activity of TNF-α converting enzyme (TACE) that cut membrane-bound TNF-α to shed its ectodomain ...
Maria Barberà-Cremades, Ana I. Gómez, Alberto Baroja-Mazo, Laura Martínez-Alarcón, Carlos M. Martínez, Carlos de Torre-Minguela, Pablo Pelegrín   +6 more
doaj   +1 more source

Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse.

PLoS ONE, 2012
The P2X7 receptor (P2X7-R) is expressed in the retina and brain and has been implicated in neurodegenerative diseases. However, whether it is expressed by neurons and plays a role as a neurotransmitter receptor has been the subject of controversy.
Kirstan A Vessey, Erica L Fletcher
doaj   +1 more source

P2X7 in Cancer: From Molecular Mechanisms to Therapeutics

Frontiers in Pharmacology, 2020
P2X7 is a transmembrane receptor expressed in multiple cell types including neurons, dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of physiological responses from pain transduction to immune response.
Romain Lara, Elena Adinolfi, Catherine A. Harwood, Mike Philpott, Julian A. Barden, Francesco Di Virgilio, Shaun McNulty   +6 more
doaj   +1 more source

Tyrosine Phosphorylation of HSP90 within the P2X7 Receptor Complex Negatively Regulates P2X7 Receptors [PDF]

Journal of Biological Chemistry, 2003
The purinergic P2X7 receptor not only gates the opening of a cationic channel, but also couples to several downstream signaling events such as rapid membrane blebbing, microvesicle shedding, and interleukin-1beta release. Protein-protein interactions are likely to be involved in most of these signaling cascades; and recently, a P2X7 receptor-protein ...
ADINOLFI, Elena, KIM M, YOUNG MT, DI VIRGILIO, Francesco, SURPRENANT A.   +4 more
openaire   +6 more sources

The Role of P2X7 Receptor in Alzheimer’s Disease [PDF]

Frontiers in Molecular Neuroscience, 2020
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease characterized by a progressive cognitive decline associated with global brain damage. Initially, intracellular paired helical filaments composed by hyperphosphorylated tau and extracellular deposits of amyloid-β (Aβ) were postulated as the causing factors of the synaptic ...
Linda Francistiová, Linda Francistiová, Carolina Bianchi, Carolina Bianchi, Caterina Di Lauro, Caterina Di Lauro, Álvaro Sebastián-Serrano, Álvaro Sebastián-Serrano, Laura de Diego-García, Laura de Diego-García, Julianna Kobolák, András Dinnyés, András Dinnyés, András Dinnyés, Miguel Díaz-Hernández, Miguel Díaz-Hernández   +15 more
openaire   +6 more sources

Pregnant Women and Endocrine Disruptors: Role of P2X7 Receptor and Mitochondrial Alterations in Placental Cell Disorders

Cells, 2022
In pregnant women, the lungs, skin and placenta are exposed daily to endocrine-disrupting chemicals (EDCs). EDCs induce multiple adverse effects, not only on endocrine organs, but also on non-endocrine organs, with the P2X7 cell death receptor being ...
Sophie Fouyet, Elodie Olivier, Pascale Leproux, Mélody Dutot, Patrice Rat   +4 more
doaj   +1 more source

The effect of anions on the human P2X7 receptor [PDF]

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011
P2X7 receptors (P2X7Rs) are nonselective cation channels that are opened by the binding of extracellular ATP and are involved in the modulation of epithelial secretion, inflammation and nociception. Here, we investigated the effect of extracellular anions on channel gating and permeation of human P2X7Rs (hP2X7Rs) expressed in Xenopus laevis oocytes ...
Kubick, Christoph, Schmalzing, Günther, Markwardt, Fritz   +2 more
openaire   +2 more sources

Purinergic signaling mediates oxidative stress in UVA-exposed THP-1 cells

Toxicology Reports, 2015
Ultraviolet A (UVA) radiation, the major UV component of solar radiation, can penetrate easily to the dermis, where it causes significant damage to cellular components by inducing formation of reactive oxygen species (ROS).
Ayumi Kawano, Akimitsu Hayakawa, Shuji Kojima, Mitsutoshi Tsukimoto, Hikaru Sakamoto   +4 more
doaj   +1 more source

Function of the P2X7 receptor in hematopoiesis and leukemogenesis [PDF]

Experimental Hematology, 2021
Adenosine triphosphate (ATP) accumulates at tissue injury and inflammation sites. The P2X7 receptor is an ATP-gated ion channel known for its cytotoxic activity. However, P2X7 receptors also play important roles in the growth of cancer and the immune regulation.
Xiaoxiao, He, Yaping, Zhang, Yilu, Xu, Li, Xie, Zhuo, Yu, Junke, Zheng   +5 more
openaire   +2 more sources