Results 21 to 30 of about 3,904,877 (199)
P2X7 Receptor as a Therapeutic Target
, 2016 P2X7 receptor is an ATP-gated cation channel that upon agonist interaction leads to cellular influx of Na+ and Ca2 + and efflux of K+. P2X7 is expressed by a wide variety of cells and its activation mediates a large number of biological processes like ...
Orioli, Elisa +7 more
core +5 more sources
The P2X7 Receptor in Tumor Immunity [PDF]
Frontiers in Cell and Developmental Biology, 2021 Extracellular adenosine triphosphate (eATP) is a potent mediator of the immune response via stimulation of purinergic P2 receptors. ATP concentration in the extracellular space increases dramatically during tissue damage and eATP acts as a danger-associated molecular pattern (DAMP) to alert innate immune system cells for tissue repair.
Fabio Grassi +2 more
openaire +4 more sources
International Journal of Molecular Sciences, 2023 Diabetic cardiomyopathy (DCM) is a critical complication of long-term chronic diabetes mellitus, and it is characterized by myocardial fibrosis and myocardial hypertrophy.
Shu-Chan Sun +10 more
semanticscholar +1 more source
Frontiers in Immunology, 2022 The P2X7 receptor is a critical purinergic receptor in immune cells. Its activation was associated with cathepsin release into macrophage cytosol, suggesting its involvement in lysosomal membrane permeabilization (LMP) and leakage.
Stephanie Alexia Cristina Silva Santos +10 more
doaj +1 more source
Medicinal research reviews (Print), 2023 The P2X7 receptor is an exceptional member of the P2X purinergic receptor family, with its activation requiring high concentrations of extracellular adenosine 5ʹ‐triphosphate (ATP) that are often associated with tissue damage and inflammation.
Ya-Ling Yin +9 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2021 Inflammatory conditions of the urinary bladder have been shown to be associated with urothelial damage and loss of function. The purinergic P2X7 receptor has been implicated in several inflammatory conditions. The aim of this study was to investigate the
Zhinoos Taidi +4 more
doaj +1 more source
Oxidative Medicine and Cellular Longevity, 2021 Osteoarthritis (OA) is an urgent public health problem; however, the underlying causal mechanisms remain unclear, especially in terms of inflammatory mediators in cartilage degradation and chondrocyte imbalance.
Zihao Li +7 more
semanticscholar +1 more source
Frontiers in Molecular Neuroscience, 2020 The ionotropic ATP-gated P2X7 receptor is an important contributor to inflammatory signaling cascades via the release of Interleukin-1β, as well as having roles in cell death, neuronal plasticity and the release of neurotransmitters.
Giorgia Conte +11 more
doaj +1 more source
Aluminum induces neuroinflammation via P2X7 receptor activating NLRP3 inflammasome pathway.
Ecotoxicology and Environmental Safety, 2022 INTRODUCTION Aluminum is everywhere in nature and is a recognized neurotoxicant closely associated with various neurodegenerative diseases. Neuroinflammation occurs in the early stage of neurodegenerative diseases, but the underlying mechanism by which ...
Xiaoying Zhu +8 more
semanticscholar +1 more source
Chlamydia psittaci inhibits apoptosis of human neutrophils by activating P2X7 receptor expression
International Journal of Medical Microbiology, 2022 This study tested the hypothesis that Chlamydia psittaci (C. psittaci) survives and multiplies in human neutrophils by activating P2X7, a nonselective cationic channel receptor expressed constitutively on the surface of these cells.
Zhangping He +11 more
doaj +1 more source