Results 21 to 30 of about 15,815 (221)
Arteriosclerosis, Thrombosis, and Vascular Biology, 2021 Chronic low-grade inflammation contributes to the development of several diseases, including cardiovascular disease. Adequate strategies to target inflammation in cardiovascular disease are in their infancy and remain an avenue of great interest. The purinergic receptor P2X7 is a ubiquitously expressed receptor that predominately mediates inflammation ...
Brandon G. Shokoples +2 more
openaire +2 more sources
The P2X7 Receptor in Infection and Inflammation [PDF]
Immunity, 2017 Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects of extracellular ATP are mediated by plasma membrane receptors named P2 receptors (P2Rs). The P2R most involved in inflammation and immunity is the P2X7 receptor (P2X7R), expressed by virtually all cells of innate and adaptive immunity.
DI VIRGILIO, Francesco +4 more
openaire +4 more sources
Role of P2X7 Receptors in Immune Responses During Neurodegeneration
Frontiers in Cellular Neuroscience, 2021 P2X7 receptors are ion-gated channels activated by ATP. Under pathological conditions, the extensive release of ATP induces sustained P2X7 receptor activation, culminating in induction of proinflammatory pathways with inflammasome assembly and cytokine ...
Ágatha Oliveira-Giacomelli +7 more
doaj +1 more source
The P2X7 Receptor, a Multifaceted Receptor in Alzheimer’s Disease
International Journal of Molecular Sciences, 2023 Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by impaired episodic memory and two pathological lesions: amyloid plaques and neurofibrillary tangles. In AD, damaged neurons and the accumulation of amyloid β (Aβ) peptides cause a significant release of high amounts of extracellular ATP, which acts as a danger signal ...
Kaitryn E. Ronning +5 more
openaire +2 more sources
Cell Death and Disease, 2021 Extracellular adenosine triphosphate (ATP) and its receptor, P2X7 receptor (P2X7R), are playing an important role in the pathological process of renal ischemia-reperfusion injury, but their underlying mechanism remains unclear.
Yingying Qian +13 more
doaj +1 more source
The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]
, 2013 Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Unwin, RJ +18 more
core +1 more source
Modulation of Cell Energy Metabolism by the P2X7 Receptor
, 2022 For many years the P2X7 receptor (P2X7R) was considered the prototypic cytolytic receptor due to its ability to cause dramatic changes in plasma membrane permeability, eventually leading to cell death.
Di Virgilio, Francesco +5 more
core +1 more source
Cell Death and Disease, 2021 Tumor growth and metastatic spreading are heavily affected by the P2X7 receptor as well as microvesicles and exosomes release into the tumor microenvironment. P2X7 receptor stimulation is known to trigger vesicular release from immune and central nervous
Anna Pegoraro +11 more
doaj +1 more source
Administration of P2X7 Receptor Blockers in Oncological Experimental Models
, 2022 The tumor microenvironment is rich in components that strongly influence cancer cell survival. One of the pivotal molecules present at the tumor bed is ATP, which has an essential role in promoting cancer proliferation and metastasis and immune responses
Adinolfi E., Pegoraro A., De Marchi E.
core +1 more source
The Role of P2X7 Receptor in Alzheimer’s Disease [PDF]
Frontiers in Molecular Neuroscience, 2020 Alzheimer's disease (AD) is the most prevalent neurodegenerative disease characterized by a progressive cognitive decline associated with global brain damage. Initially, intracellular paired helical filaments composed by hyperphosphorylated tau and extracellular deposits of amyloid-β (Aβ) were postulated as the causing factors of the synaptic ...
Linda Francistiová +15 more
openaire +6 more sources