Results 11 to 20 of about 3,904,877 (199)
P2X7 Receptor in Hematological Malignancies [PDF]
Frontiers in Cell and Developmental Biology, 2021 The P2X7 receptor is an ion channel gated by the nucleotide ATP, known for its role in immune responses and recently emerging as a critical onco-promoting factor.
Elena De Marchi +2 more
doaj +5 more sources
P2X7 Receptor Signaling in Stress and Depression [PDF]
International Journal of Molecular Sciences, 2019 Stress exposure is considered to be the main environmental cause associated with the development of depression. Due to the limitations of currently available antidepressants, a search for new pharmacological targets for treatment of depression is ...
Gregers Wegener +2 more
exaly +5 more sources
The P2X7 Receptor in Autoimmunity
International Journal of Molecular Sciences, 2023 The P2X7 receptor (P2X7R) is an ATP-gated nonselective cationic channel that, upon intense stimulation, can progress to the opening of a pore permeable to molecules up to 900 Da.
Fabio Grassi, Gaia Salina
semanticscholar +5 more sources
Tyrosine phosphorylation of HSP90 within the P2X7 receptor complex negatively regulates P2X7 receptors [PDF]
Journal of Biological Chemistry, 2003 The purinergic P2X7 receptor not only gates the opening of a cationic channel, but also couples to several downstream signaling events such as rapid membrane blebbing, microvesicle shedding, and interleukin-1 release.
ADINOLFI, Elena +4 more
core +8 more sources
The P2X7 Receptor in Osteoarthritis [PDF]
Frontiers in Cell and Developmental Biology, 2021 Osteoarthritis (OA) is the most common joint disease. With the increasing aging population, the associated socio-economic costs are also increasing.
Zihao Li, Ziyu Huang, L. Bai
semanticscholar +4 more sources
The P2X7 Receptor, a Multifaceted Receptor in Alzheimer’s Disease
International Journal of Molecular Sciences, 2023 Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by impaired episodic memory and two pathological lesions: amyloid plaques and neurofibrillary tangles.
Kaitryn E. Ronning +5 more
semanticscholar +3 more sources
Tissue distribution of the P2X7 receptor
Neuropharmacology, 1997 The P2X7 receptor is a bifunctional molecule. The binding of ATP induces within milliseconds the opening of a channel selective for small cations, and within seconds a larger pore opens which allows permeation by molecules as large as propidium dyes (629
Kawashima, E. +11 more
core +5 more sources
Molecular Pain, 2022 Background The transition from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype presents a novel therapeutic strategy for chronic pain.
Ping Wu +5 more
doaj +2 more sources
The Journal of Headache and Pain, 2021 Highlights • SFKs activity-mediated P2X7 receptor signaling facilitates CSD propagation via glutamatergic pathway and also promotes neuroinflammation. • P2X7 receptor/SFKs signaling can be targeted for migraine prophylaxis and therapy.
Lingdi Nie +3 more
doaj +2 more sources
The P2X7 Receptor in Infection and Inflammation [PDF]
Immunity, 2017 Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects of extracellular ATP are mediated by plasma membrane receptors named P2 receptors (P2Rs). The P2R most involved in inflammation and immunity is the P2X7 receptor (P2X7R), expressed by virtually all cells of innate and adaptive immunity.
F. Di Virgilio +4 more
semanticscholar +5 more sources