Results 11 to 20 of about 12,681 (186)
P2X7 Receptor in Hematological Malignancies [PDF]
Frontiers in Cell and Developmental Biology, 2021 The P2X7 receptor is an ion channel gated by the nucleotide ATP, known for its role in immune responses and recently emerging as a critical onco-promoting factor.
Elena De Marchi +2 more
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The P2X7 Receptor in Osteoarthritis [PDF]
Frontiers in Cell and Developmental Biology, 2021 Osteoarthritis (OA) is the most common joint disease. With the increasing aging population, the associated socio-economic costs are also increasing. Analgesia and surgery are the primary treatment options in late-stage OA, with drug treatment only possible in early prevention to improve patients’ quality of life. The most important structural component
Zihao Li, Ziyu Huang, Lunhao Bai
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The P2X7 Receptor in Tumor Immunity [PDF]
Frontiers in Cell and Developmental Biology, 2021 Extracellular adenosine triphosphate (eATP) is a potent mediator of the immune response via stimulation of purinergic P2 receptors. ATP concentration in the extracellular space increases dramatically during tissue damage and eATP acts as a danger-associated molecular pattern (DAMP) to alert innate immune system cells for tissue repair.
Fabio Grassi +2 more
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The P2X7 Receptor in Autoimmunity
International Journal of Molecular Sciences, 2023 The P2X7 receptor (P2X7R) is an ATP-gated nonselective cationic channel that, upon intense stimulation, can progress to the opening of a pore permeable to molecules up to 900 Da. Apart from its broad expression in cells of the innate and adaptive immune systems, it is expressed in multiple cell types in different tissues.
Fabio Grassi, Gaia Salina
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The P2X7 Receptor in Infection and Inflammation [PDF]
Immunity, 2017 Adenosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects of extracellular ATP are mediated by plasma membrane receptors named P2 receptors (P2Rs). The P2R most involved in inflammation and immunity is the P2X7 receptor (P2X7R), expressed by virtually all cells of innate and adaptive immunity.
DI VIRGILIO, Francesco +4 more
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2021 Chronic low-grade inflammation contributes to the development of several diseases, including cardiovascular disease. Adequate strategies to target inflammation in cardiovascular disease are in their infancy and remain an avenue of great interest. The purinergic receptor P2X7 is a ubiquitously expressed receptor that predominately mediates inflammation ...
Brandon G. Shokoples +2 more
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Role of P2X7 Receptors in Immune Responses During Neurodegeneration
Frontiers in Cellular Neuroscience, 2021 P2X7 receptors are ion-gated channels activated by ATP. Under pathological conditions, the extensive release of ATP induces sustained P2X7 receptor activation, culminating in induction of proinflammatory pathways with inflammasome assembly and cytokine ...
Ágatha Oliveira-Giacomelli +7 more
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Cell Death and Disease, 2021 Extracellular adenosine triphosphate (ATP) and its receptor, P2X7 receptor (P2X7R), are playing an important role in the pathological process of renal ischemia-reperfusion injury, but their underlying mechanism remains unclear.
Yingying Qian +13 more
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Cell Death and Disease, 2021 Tumor growth and metastatic spreading are heavily affected by the P2X7 receptor as well as microvesicles and exosomes release into the tumor microenvironment. P2X7 receptor stimulation is known to trigger vesicular release from immune and central nervous
Anna Pegoraro +11 more
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The P2X7 Receptor, a Multifaceted Receptor in Alzheimer’s Disease
International Journal of Molecular Sciences, 2023 Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by impaired episodic memory and two pathological lesions: amyloid plaques and neurofibrillary tangles. In AD, damaged neurons and the accumulation of amyloid β (Aβ) peptides cause a significant release of high amounts of extracellular ATP, which acts as a danger signal ...
Kaitryn E. Ronning +5 more
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