Results 41 to 50 of about 3,904,877 (199)

Structural basis for the functional properties of the P2X7 receptor for extracellular ATP

Purinergic Signalling Purinergic Signalling, 2021
The P2X7 receptor, originally known as the P2Z receptor due to its distinctive functional properties, has a structure characteristic of the ATP-gated ion channel P2X receptor family.
Lin-Hua Jiang, Emily A. Caseley, S. Muench, Sébastien Roger   +3 more
semanticscholar   +1 more source

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. [PDF]

, 2013
Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7) results in an antidepressant phenotype in mice. However, the link between the deficiency of P2rx7 and changes in behavior has not yet been explored.
Zsilla Gabriella, Csölle Cecília, Csölle, Cecília, Illes Peter, Flóra Gölöncsér, Gabriella Zsilla, Mária Baranyi, Sperlágh, Beáta, Baranyi, Mária, Kittel Ágnes, Peter Illes, Baranyi Mária, Beáta Sperlágh, Vizi E. Szilveszter, E Sylvester Vizi, Zsilla, Gabriella, Papp Edit, Gölöncsér Flóra, Illés, Péter, Gölöncsér, Flóra, E. Sylvester Vizi, Sperlágh Beáta, Illes P, Vizi, E. Szilveszter, Papp, Edit, Edit Papp, Kittel, Ágnes, Agnes Kittel, Cecilia Csölle, Vizi E. Sylvester   +29 more
core   +2 more sources

Human P2Y11 Expression Level Affects Human P2X7 Receptor-Mediated Cell Death

Frontiers in Immunology, 2018
Adenosine triphosphate (ATP) is known to induce cell death in T lymphocytes at high extracellular concentrations. CD4+ and CD8+ T lymphocytes have a differential response to ATP, which in mice is due to differences in the P2X7 receptor expression levels.
Karin Dreisig, Louise Sund, Maja Wallentin Dommer, Nikolaj Pagh Kristensen, Kim Boddum, Rannveig Viste, Simon Fredholm, Niels Odum, Marja Jäättelä, Søren Skov, Birgitte R. Kornum, Birgitte R. Kornum   +11 more
doaj   +1 more source

P2X7 Receptor Induces Tumor Necrosis Factor-α Converting Enzyme Activation and Release to Boost TNF-α Production

Frontiers in Immunology, 2017
Tumor necrosis factor (TNF)-α is a major pro-inflammatory cytokine produced in response to toll-like receptor stimulation. TNF-α release is controlled by the activity of TNF-α converting enzyme (TACE) that cut membrane-bound TNF-α to shed its ectodomain ...
Maria Barberà-Cremades, Ana I. Gómez, Alberto Baroja-Mazo, Laura Martínez-Alarcón, Carlos M. Martínez, Carlos de Torre-Minguela, Pablo Pelegrín   +6 more
doaj   +1 more source

Astroglial and Microglial Purinergic P2X7 Receptor as a Major Contributor to Neuroinflammation during the Course of Multiple Sclerosis

International Journal of Molecular Sciences, 2021
Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system that leads to the progressive disability of patients. A characteristic feature of the disease is the presence of focal demyelinating lesions accompanied by an ...
M. Sidoryk-Węgrzynowicz, L. Strużyńska   +1 more
semanticscholar   +1 more source

P2X7 receptor signaling during adult hippocampal neurogenesis [PDF]

, 2019
Neurogenesis is a persistent and essential feature of the adult mammalian hippocampus. Granular neurons generated from resident pools of stem or progenitor cells provide a mechanism for the formation and consolidation of new memories.
Lovelace, Michael, Leeson, Hannah, Chan-Ling, Tailoi, Leeson, H, Leeson, Hannah C, Weible, Michael, Brownlie, Jeremy C, Gu, Ben J, Lovelace, Michael D, Gu, Ben, Chan-Ling, T, Weible, Michael W, Brownlie, J, Brownlie, Jeremy, Lovelace, M ; https://orcid.org/, Weible, M, Gu, B   +16 more
core   +1 more source

Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse.

PLoS ONE, 2012
The P2X7 receptor (P2X7-R) is expressed in the retina and brain and has been implicated in neurodegenerative diseases. However, whether it is expressed by neurons and plays a role as a neurotransmitter receptor has been the subject of controversy.
Kirstan A Vessey, Erica L Fletcher
doaj   +1 more source

Alternatively Spliced Isoforms of the P2X7 Receptor: Structure, Function and Disease Associations

International Journal of Molecular Sciences, 2022
The P2X7 receptor (P2X7R) is an ATP-gated membrane ion channel that is expressed by multiple cell types. Following activation by extracellular ATP, the P2X7R mediates a broad range of cellular responses including cytokine and chemokine release, cell ...
Sophie K. F. De Salis, Lanxin Li, Zheng Chen, Kam-Wa Lam, Kristen K. Skarratt, T. Balle, S. Fuller   +6 more
semanticscholar   +1 more source

PET Radioligands for in Vivo Visualization of Neuroinflammation. [PDF]

, 2014
Neuroinflammation is a well-orchestrated, dynamic, multicellular process playing a major role in neurodegenerative disorders. The microglia which make up the innate immune system of the central nervous system are key cellular mediators of ...
Ory, Dieter, Celeb, Sofie, Celen, Sofie, Verbruggen, Alfons, Bormans, Guy   +4 more
core   +1 more source

The effect of anions on the human P2X7 receptor [PDF]

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011
P2X7 receptors (P2X7Rs) are nonselective cation channels that are opened by the binding of extracellular ATP and are involved in the modulation of epithelial secretion, inflammation and nociception. Here, we investigated the effect of extracellular anions on channel gating and permeation of human P2X7Rs (hP2X7Rs) expressed in Xenopus laevis oocytes ...
Kubick, Christoph, Schmalzing, Günther, Markwardt, Fritz   +2 more
openaire   +2 more sources