Results 41 to 50 of about 12,681 (186)
WONOEP appraisal: Biomarkers and treatment strategies beyond the synapse
Epilepsia, EarlyView.Abstract Epilepsy is a heterogeneous neurological disorder affecting more than 70 million people worldwide, posing significant challenges for clinicians due to its complex etiology, diverse manifestations, variable treatment responses, and the inability to predict seizures or disease onset reliably.
Mirte Scheper +11 more
wiley +1 more source
The Journal of Headache and Pain, 2021 Highlights • SFKs activity-mediated P2X7 receptor signaling facilitates CSD propagation via glutamatergic pathway and also promotes neuroinflammation. • P2X7 receptor/SFKs signaling can be targeted for migraine prophylaxis and therapy.
Lingdi Nie +3 more
doaj +1 more source
P2X7 Receptor–Mediated Inflammation in Cardiovascular Disease
Frontiers in Pharmacology, 2021 Purinergic P2X7 receptor, a nonselective cation channel, is highly expressed in immune cells as well as cardiac smooth muscle cells and endothelial cells.
Junteng Zhou +9 more
doaj +1 more source
International Journal of Cancer, EarlyView.ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang +10 more
wiley +1 more source
Expression and Purification of a Mammalian P2X7 Receptor from Sf9 Insect Cells
Bio-Protocol, 2017 The P2X7 receptor is an extracellular ATP-gated ion channel found only in eukaryotes (Bartlett et al., 2014). Due to its unique properties among P2X receptors, such as formation of a large conductance pore, the P2X7 receptor has been implicated in ...
Akira Karasawa, Toshimitsu Kawate
doaj +1 more source
Current Issues in Molecular Biology, 2021 Background: Breast cancer is the most common malignancy in women worldwide. P2X7 is a transmembrane receptor expressed in breast cancer and activated by the ATP tumor microenvironment, driving cell proliferation, angiogenesis, and metastasis via ...
Muhammed M. Salahuddin +3 more
doaj +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Mold growth in damp indoor environments is a widespread problem associated with respiratory health effects, though causal mechanisms remain incompletely understood. We established a human cell‐based in vitro test system using bronchial epithelial cells (NuLi‐1) and macrophages (THP‐1) to assess inhalation toxicity and immunomodulatory effects ...
Anja Wolff +8 more
wiley +1 more source
The P2X7 receptor in mucosal adaptive immunity
Purinergic Signalling, 2023 AbstractThe P2X7 receptor (P2X7R) is a widely distributed cation channel activated by extracellular ATP (eATP) with exclusive peculiarities with respect to other P2XRs. In recent years, P2X7R has been shown to regulate the adaptive immune response by conditioning T cell signaling and activation as well as polarization, lineage stability, cell death ...
Grassi, Fabio, Marino, Rebecca
openaire +3 more sources
The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?
Frontiers in Pharmacology, 2018 Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the extracellular milieu, being massively released by stressed or dying cells.
Luiz E. B. Savio +3 more
doaj +1 more source
The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source