Results 41 to 50 of about 15,815 (221)
PET Radioligands for in Vivo Visualization of Neuroinflammation. [PDF]
, 2014 Neuroinflammation is a well-orchestrated, dynamic, multicellular process playing a major role in neurodegenerative disorders. The microglia which make up the innate immune system of the central nervous system are key cellular mediators of ...
Ory, Dieter +4 more
core +1 more source
Purinergic signaling mediates oxidative stress in UVA-exposed THP-1 cells
Toxicology Reports, 2015 Ultraviolet A (UVA) radiation, the major UV component of solar radiation, can penetrate easily to the dermis, where it causes significant damage to cellular components by inducing formation of reactive oxygen species (ROS).
Ayumi Kawano +4 more
doaj +1 more source
Journal of Osteoporosis, 2012 P2X7 receptor-mediated purinergic signaling is a well-known mechanism involved in bone remodeling. The P2X7 receptor has been implicated in the pathophysiology of various bone and cartilage diseases, including rheumatoid arthritis (RA), a widespread and ...
Alberto Baroja-Mazo, Pablo Pelegrín
doaj +1 more source
Journal of Neuroinflammation, 2021 Background The identification of endogenous signals that lead to microglial activation is a key step in understanding neuroinflammatory cascades. As ATP release accompanies mechanical strain to neural tissue, and as the P2X7 receptor for ATP is expressed
Keith E. Campagno +9 more
doaj +1 more source
PLoS Pathogens, 2017 A complete understanding of the mechanisms underlying the acquisition of protective immunity is crucial to improve vaccine strategies to eradicate malaria.
Érika Machado de Salles +13 more
doaj +1 more source
The C-terminus of human nucleotide receptor P2X7 is critical for receptor oligomerization and N-linked glycosylation. [PDF]
PLoS ONE, 2013 The P2X7 receptor binds extracellular ATP to mediate numerous inflammatory responses and is considered a potential biomarker and therapeutic target for diverse inflammatory and neurological diseases.
Lisa E Wickert +6 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 Purinergic receptors play important roles in central nervous system (CNS), where the bulk of these receptors are implicated in neuroinflammatory responses and regulation of cellular function of neurons, microglial and astrocytes.
Paul R. Territo +2 more
doaj +1 more source
Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury
, 2016 Context: Military recruits and elite athletes are susceptible to stress fracture injuries. Genetic predisposition has been postulated to have a role in their development.
Gallagher, JA +25 more
core +1 more source
The P2X7 receptor in mucosal adaptive immunity
Purinergic Signalling, 2023 AbstractThe P2X7 receptor (P2X7R) is a widely distributed cation channel activated by extracellular ATP (eATP) with exclusive peculiarities with respect to other P2XRs. In recent years, P2X7R has been shown to regulate the adaptive immune response by conditioning T cell signaling and activation as well as polarization, lineage stability, cell death ...
Grassi, Fabio, Marino, Rebecca
openaire +3 more sources
Frontiers in Pharmacology, 2023 Introduction: Sepsis is defined as a multifactorial debilitating condition with high risks of death. The intense inflammatory response causes deleterious effects on the brain, a condition called sepsis-associated encephalopathy.
Vinícius Santos Alves +17 more
doaj +1 more source