Resveratrol inhibits Cdk5 activity through regulation of p35 expression [PDF]
Molecular Pain, 2011 Background We have previously reported that cyclin-dependent kinase 5 (Cdk5) participates in the regulation of nociceptive signaling. Through activation of the ERK1/2 pathway, Tumor Necrosis Factor-α (TNF-α) induces expression of Egr-1.
Kulkarni Ashok B +4 more
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Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5. [PDF]
PLoS ONE, 2015 p35 is an activation subunit of the cyclin-dependent kinase 5 (CDK5), which is a Ser/Thr kinase that is expressed predominantly in neurons. Disruption of the CDK5 or p35 (CDK5R1) genes induces abnormal neuronal layering in various regions of the mouse ...
Shunsuke Takada +5 more
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Disruption of CDK5 regulatory subunit 1, p35, limits immunosuppressive M2 macrophages while maintaining functional M1 macrophages [PDF]
Frontiers in ImmunologyIntroductionMacrophage polarization into M1 or M2 phenotypes is a complex process influenced by various factors. However, existing literature and ongoing research support the view that Cyclin-Dependent Kinase 5 (CDK5) may play an important role in this ...
Juliana R. Zampieri +9 more
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Unveiling the TrkA-p35/CDK5 axis: a novel therapeutic target in diabetic kidney disease [PDF]
Frontiers in EndocrinologyObjectiveTo investigate the potential crosstalk between TrkA, the high-affinity nerve growth factor receptor (NGFR), and cyclin-dependent kinase 5 (CDK5) in the pathogenesis of diabetic kidney disease (DKD).
Wenbo Xia +10 more
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A novel mineralization-inductive peptide derived from CEMP1functinal domains [PDF]
Scientific ReportsA novel biomimetic peptide (P35) was designed and synthesized by combining the N-terminal 20 amino acids and the C-terminal 15 amino acids of cementum protein 1 (CEMP1), guided by molecular docking and plasmid-based molecular engineering (sequence ...
Yu Wang +4 more
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Screening the receptors for Mycoplasma penetrans P35 lipoprotein and characterization of its functional binding domains [PDF]
Frontiers in Cellular and Infection MicrobiologyMycoplasma penetrans, a prokaryotic microorganism initially isolated from the urine of a patient infected with human immunodeficiency virus (HIV), possesses a distinctive elongated flask-like shape and a tip-like structure.
Xia Li +10 more
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High interleukin-35 expression is associated with the severity of rheumatic mitral stenosis [PDF]
Frontiers in ImmunologyBackgroundRheumatic mitral stenosis (RMS) is the most common manifestation of rheumatic heart disease, with high morbidity and mortality. Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine associated with many autoimmune diseases.
Ping Wang +8 more
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New p35 (H3L) Epitope Involved in Vaccinia Virus Neutralization and Its Deimmunization
Viruses, 2022 Vaccinia virus (VACV) is a promising oncolytic agent because it exhibits many characteristic features of an oncolytic virus. However, its effectiveness is limited by the strong antiviral immune response induced by this virus.
Yana Khlusevich +6 more
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Knockdown of Expression of Cdk5 or p35 (a Cdk5 Activator) Results in Podocyte Apoptosis. [PDF]
PLoS ONE, 2016 Podocytes are terminally differentiated glomerular epithelial cells. Podocyte loss has been found in many renal diseases. Cdk5 is a cyclin-dependent protein kinase which is predominantly regulated by p35.
Ya-Li Zheng +11 more
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Characterization and Evaluation of a Novel Conserved Membrane Antigen P35 of Mycoplasma synoviae
Frontiers in Veterinary Science, 2022 Mycoplasma synoviae (MS) is a major avian pathogen that causes respiratory damage, infectious synovitis, and arthritis in chickens and causes serious economic losses to the global poultry industry. Despite its significance, knowledge on pathogenicity and
Qianjin Sun +11 more
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