Results 91 to 100 of about 76,399 (242)

Cdk5/p35 functions as a crucial regulator of spatial learning and memory

Molecular Brain, 2014
BackgroundCyclin-dependent kinase 5 (Cdk5), which is activated by binding to p35 or p39, is involved in synaptic plasticity and affects learning and memory formation.
Tomohide Mishiba, Mika Tanaka, Naoki Mita, Xiaojuan He, Kodai Sasamoto, S. Itohara, T. Ohshima   +6 more
semanticscholar   +1 more source

A Model to Explain How the Bacille Calmette Guérin (BCG) Vaccine Drives Interleukin-12 Production in Neonates. [PDF]

PLoS ONE, 2016
The Bacille Calmette Guérin (BCG) vaccine is the only routine vaccination at birth that effectively induces neonatal T-helper 1 (Th1)-polarized immune responses. The primary cytokine that drives CD4+ T-cell Th1 differentiation is interleukin (IL)-12 p70,
Chido Loveness Kativhu, Daniel H Libraty
doaj   +1 more source

‘Being an Outsider’ and ‘Being an Insider’: A Focused Ethnography of Family Members' Visitation Experiences in an Adult ICU

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims To explore how the restricted visitation policy impacts family members' visitation experiences and perceptions in an adult intensive care unit (ICU). Design Focused ethnography. Methods Data collection included 39 observation sessions (totalling 65.3 h), 19 semi‐structured interviews with family members, and document analysis of policies ...
Lian Zhu, Susanne Kean, Catherine Clarissa, Jennifer Tocher   +3 more
wiley   +1 more source

Physiological and pathological phosphorylation of tau by Cdk5

Frontiers in Molecular Neuroscience, 2014
Hyperphosphorylation of microtubule-associated protein tau is one of the major pathological events in Alzheimer’s disease (AD) and other related neurodegenerative diseases, including Frontotemporal Dementia with Parkinsonism linked to chromosome 17 (FTDP-
Taeko eKimura, Koichi eIshiguro, Shin-Ichi eHisanaga   +2 more
doaj   +1 more source

The role of miR-103 and miR-107 in regulation of CDK5R1 expression and in cellular migration. [PDF]

PLoS ONE, 2011
CDK5R1 encodes p35, a specific activator of the serine/threonine kinase CDK5, which plays crucial roles in CNS development and maintenance. CDK5 activity strongly depends on p35 levels and p35/CDK5 misregulation is deleterious for correct CNS function ...
Silvia Moncini, Alessandro Salvi, Paola Zuccotti, Gabriella Viero, Alessandro Quattrone, Sergio Barlati, Giuseppina De Petro, Marco Venturin, Paola Riva   +8 more
doaj   +1 more source

Entanglement entropy of multipartite pure states

, 2002
Consider a system consisting of $n$ $d$-dimensional quantum particles and arbitrary pure state $\Psi$ of the whole system. Suppose we simultaneously perform complete von Neumann measurements on each particle.
C. Bennett, G. Vidal, S. Popescu, Sergei Bravyi   +3 more
core   +1 more source

What do public contributors with lived experience know and think about open research? ‘Nobody should look at results and think “how did they arrive at that?”’

Journal of Neuropsychology, EarlyView.
Abstract Involving people with lived experience in research (patient and public involvement or co‐production) is one principle of open research (transparent research practices). Involvement of experts by experience helps ensure that clinical and health research is relevant, ethical and accessible.
Ellen Poliakoff, Hayley Shepherd, Ying Bai, Jade Pickering, Anne Ferrett, Peter Baimbridge, Graham Hanks, Emma Gowen   +7 more
wiley   +1 more source

Simultaneous reduction of dietary protein and daily feeding rate in biofloc system: Effect on water quality, growth, digestive and antioxidant capacity, immune response, and resistance to Aeromonas hydrophila in common carp

Aquaculture Reports
This experiment evaluated the impacts of simultaneous reduction of dietary protein and daily feeding rate in a biofloc system on performance of common carp, Cyprinus carpio.
Hossein Adineh, Mahdi Naderi, Mohammad Amini Chermahini, Golbahar Zeitounli, Mohammad Meysam Salahi Ardekani   +4 more
doaj   +1 more source

Synchronous and symmetric migration of Drosophila caudal visceral mesoderm cells requires dual input by two FGF ligands [PDF]

, 2012
Caudal visceral mesoderm (CVM) cells migrate synchronously towards the anterior of the Drosophila embryo as two distinct groups located on each side of the body, in order to specify longitudinal muscles that ensheath the gut.
Ghosh, Srimoyee, Kadam, Snehalata, Stathopoulos, Angelike   +2 more
core   +1 more source

Comfort Needs of Renal Transplant Recipients: A Qualitative Analysis Guided by Kolcaba's Theory of Comfort

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim To analyse the comfort needs of patients following renal transplantation, guided by Kolcaba's Theory of Comfort. Design A qualitative design was employed. Methods This study was conducted at a Brazilian university hospital's renal transplant outpatient clinic.
Cecília Carla Barroso Calazans, Jennara Cândido do Nascimento, Renan Alves da silva, Francisco Gilberto Fernandes Pereira, Lívia Moreira Barros, Joselany Áfio Caetano   +5 more
wiley   +1 more source