Results 11 to 20 of about 76,399 (242)

LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains

Acta Neuropathologica Communications, 2019
Cyclin dependent kinase-5 (cdk5)/p35 is a neuronal kinase that regulates key axonal and synaptic functions but the mechanisms by which it is transported to these locations are unknown. Lemur tyrosine kinase-2 (LMTK2) is a binding partner for p35 and here
Gábor M. Mórotz, Elizabeth B. Glennon, Patricia Gomez-Suaga, Dawn H. W. Lau, Eleanor D. Robinson, Éva Sedlák, Alessio Vagnoni, Wendy Noble, Christopher C. J. Miller   +8 more
doaj   +2 more sources

Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons

Molecular Brain, 2022
Cyclin-dependent kinase 5 (Cdk5) /p35 is involved in many developmental processes of the central nervous system. Cdk5/p35 is also implicated in synaptic plasticity, learning and memory.
Miyuki Takahashi, Takeru Nakabayashi, Naoki Mita, Xiaohua Jin, Yuta Aikawa, Kodai Sasamoto, Goichi Miyoshi, Mariko Miyata, Takafumi Inoue, Toshio Ohshima   +9 more
doaj   +2 more sources

Contribution of IL-12/IL-35 common subunit p35 to maintaining the testicular immune privilege.

PLoS ONE, 2014
The testis is an organ with immune privilege. The comprehensive blood-testis barrier formed by Sertoli cells protects autoimmunogenic spermatozoa and spermatids from attack by the body's immune system. The interleukin (IL)-6/IL-12 family cytokines IL-12 (
Hayato Terayama, Takayuki Yoshimoto, Shuichi Hirai, Munekazu Naito, Ning Qu, Naoyuki Hatayama, Shogo Hayashi, Kana Mitobe, Jun-Ichi Furusawa, Izuru Mizoguchi, Takeshi Kezuka, Hiroshi Goto, Kaori Suyama, Hiroshi Moriyama, Kou Sakabe, Masahiro Itoh   +15 more
doaj   +2 more sources

The interaction of Munc 18 (p67) with the p10 domain of p35 protects in vivo Cdk5/p35 activity from inhibition by TFP5, a peptide derived from p35

Molecular Biology of the Cell, 2016
In a series of studies, we have identified TFP5, a truncated fragment of p35, the Cdk5 kinase regulatory protein, which inhibits Cdk5/p35 and the hyperactive Cdk5/p25 activities in test tube experiments. In cortical neurons, however, and in vivo in Alzheimer’s disease (AD) model mice, the peptide specifically inhibits the Cdk5/p25 complex and not the ...
Amin, Niranjana D., Zheng, Yali, BK, Binukumar, Shukla, Varsha, Skuntz, Susan, Grant, Philip, Steiner, Joseph, Bhaskar, Manju, Pant, Harish C.   +8 more
openaire   +3 more sources

Axonal cap‐dependent translation regulates presynaptic p35 [PDF]

Developmental Neurobiology, 2013
ABSTRACTAxonal growth cones synthesize proteins during development and in response to injury in adult animals. Proteins locally translated in axons are used to generate appropriate responses to guidance cues, contribute to axon growth, and can serve as retrograde messengers.
Kuangfu, Hsiao, Ozlem, Bozdagi, Deanna L, Benson   +2 more
openaire   +3 more sources

Sumoylation of p35 Modulates p35/Cyclin-Dependent Kinase (Cdk) 5 Complex Activity

NeuroMolecular Medicine, 2014
Cyclin-dependent kinase (Cdk) 5 is critical for central nervous system development and neuron-specific functions including neurite outgrowth as well as synaptic function and plasticity. Cdk5 activity requires association with one of the two regulatory subunits, called p35 and p39. p35 redistribution as well as misregulation of Cdk5 activity is followed
Büchner, A., Krumova, P., Ganesan, S., Bähr, M., Eckermann, K., Weishaupt, J. H.   +5 more
openaire   +4 more sources

Oncolytic adenovirus expressing IL-23 and p35 elicits IFN-γ- and TNF-α-co-producing T cell-mediated antitumor immunity. [PDF]

PLoS ONE, 2013
Cytokine immunogene therapy is a promising strategy for cancer treatment. Interleukin (IL)-12 boosts potent antitumor immunity by inducing T helper 1 cell differentiation and stimulating cytotoxic T lymphocyte and natural killer cell cytotoxicity.
Il-Kyu Choi, Yan Li, Eonju Oh, Jaesung Kim, Chae-Ok Yun   +4 more
doaj   +2 more sources

Vps35 Deficiency Impairs Cdk5/p35 Degradation and Promotes the Hyperphosphorylation of Tau Protein in Retinal Ganglion Cells

Investigative Ophthalmology and Visual Science, 2020
Purpose Vacuolar protein sorting 35 (Vps35) mutations and protein dysfunction have been linked to the hyperphosphorylation and accumulation of tau protein in a number of central neurodegenerative disorders.
Ling Gao, Hang Xiao, Liqianyu Ai, Chunlin Chen, Sen Lin, Yuan-Guo Zhou, Jian Ye, Wei Liu   +7 more
semanticscholar   +1 more source

Caspase inhibitors of the P35 family are more active when purified from yeast than bacteria. [PDF]

PLoS ONE, 2012
Many insect viruses express caspase inhibitors of the P35 superfamily, which prevent defensive host apoptosis to enable viral propagation. The prototypical P35 family member, AcP35 from Autographa californica M nucleopolyhedrovirus, has been extensively ...
Ingo L Brand, Srgjan Civciristov, Nicole L Taylor, Gert H Talbo, Delara Pantaki-Eimany, Vita Levina, Rollie J Clem, Matthew A Perugini, Marc Kvansakul, Christine J Hawkins   +9 more
doaj   +1 more source

Cheek Augmentation With Dermicol-P35 27G [PDF]

Aesthetic Surgery Journal, 2009
Full and high cheekbones are considered a desirable component of facial attractiveness. The aging process can result in a loss of facial volume and changes in facial contours. Cheek augmentation can replace lost facial volume, rejuvenate facial appearance, enhance cheek prominence, and improve facial symmetry.
Neil S, Sadick, Laura, Palmisano
openaire   +5 more sources