Results 21 to 30 of about 67,493 (202)

Hepatic fascioliasis presenting with bile duct obstruction: a case report

open access: yesThe Pan African Medical Journal, 2017
Fascioliasis is a zoonotic infection caused by a liver trematode: fasciola hepatica; which commonly affects cattle and sheep, humans are accidental hosts. Several cases have been reported in the literature worldwide with a large geographical distribution.
Rachid Lefriyekh   +10 more
doaj   +1 more source

Expression of the Baculovirus p35 Protein in Tobacco Affects Cell Death Progression and Compromises N Gene-Mediated Disease Resistance Response to Tobacco mosaic virus

open access: yesMolecular Plant-Microbe Interactions, 2003
The p35 protein from baculovirus is a broad-range caspase inhibitor and suppresses programmed cell death in animals. We report here the effects of transgenic expression in tobacco of the p35 protein during the hypersensitive response (HR).
Olga del Pozo, Eric Lam
doaj   +1 more source

Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide+

open access: yesBMC Cancer, 2010
Background Cytochrome P450-based suicide gene therapy for cancer using prodrugs such as cyclophosphamide (CPA) increases anti-tumor activity, both directly and via a bystander killing mechanism.
Doloff Joshua C, Su Ting, Waxman David J
doaj   +1 more source

Focusing on cyclin-dependent kinases 5: A potential target for neurological disorders

open access: yesFrontiers in Molecular Neuroscience, 2022
Cyclin-dependent kinases 5 (Cdk5) is a special member of proline-directed serine threonine kinase family. Unlike other Cdks, Cdk5 is not directly involved in cell cycle regulation but plays important roles in nervous system functions. Under physiological
Zhen Tian   +3 more
doaj   +1 more source

Distribution of winners in truel games [PDF]

open access: yes, 2005
In this work we present a detailed analysis using the Markov chain theory of some versions of the truel game in which three players try to eliminate each other in a series of one-to-one competitions, using the rules of the game.
Amengual, P., Toral, R.
core   +3 more sources

Metformin Ameliorates Synaptic Defects in a Mouse Model of AD by Inhibiting Cdk5 Activity

open access: yesFrontiers in Cellular Neuroscience, 2020
Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is activated by the neuron-specific activators p35/p39 and plays important roles in neuronal development, synaptic plasticity, and cognitive behavior. However, the proteolytic cleavage of
YaLi Wang   +14 more
doaj   +1 more source

Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression

open access: yesCell Reports, 2018
Summary: Menin (MEN1) is a critical modulator of tissue development and maintenance. As such, MEN1 mutations are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome.
Kai Zhuang   +18 more
doaj   +1 more source

Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer’s disease

open access: yesMolecular Therapy: Nucleic Acids, 2022
Existing studies have revealed that microRNAs (miRNAs) have a role in cognitive deficits in Alzheimer’s disease (AD). However, the function and pathophysiological mechanism of deregulated miRNAs underlying AD pathology remain to be investigated.
Li Zeng   +8 more
doaj   +1 more source

Intergovernmental Fiscal Transfers and Tax Collection of Indian States: Estimation from Panel Data Models

open access: yesActa Universitatis Sapientiae: Economics and Business, 2023
This study tries to empirically estimate the effects of the composition of intergovernmental transfers on tax collection across the Indian states by using panel regression model.
Kumar Sumit, Kaur Baljit
doaj   +1 more source

A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration [PDF]

open access: yes, 2012
Axonal degeneration is a molecular self-destruction cascade initiated following traumatic, toxic, and metabolic insults. Its mechanism underlies a number of disorders including hereditary and diabetic neuropathies and the neurotoxic side effects of ...
Bhattacharya, Martha R.C.   +7 more
core   +2 more sources

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