Results 31 to 40 of about 76,399 (242)

Resveratrol inhibits Cdk5 activity through regulation of p35 expression

Molecular Pain, 2011
Background We have previously reported that cyclin-dependent kinase 5 (Cdk5) participates in the regulation of nociceptive signaling. Through activation of the ERK1/2 pathway, Tumor Necrosis Factor-α (TNF-α) induces expression of Egr-1.
Kulkarni Ashok B, Iadarola Michael J, Keller Jason, Terse Anita, Utreras Elias   +4 more
doaj   +1 more source

Metformin Ameliorates Synaptic Defects in a Mouse Model of AD by Inhibiting Cdk5 Activity

Frontiers in Cellular Neuroscience, 2020
Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is activated by the neuron-specific activators p35/p39 and plays important roles in neuronal development, synaptic plasticity, and cognitive behavior. However, the proteolytic cleavage of
YaLi Wang, JianHua Zhao, Fang-Li Guo, XiaHuan Gao, Xine Xie, ShouQing Liu, Xin Yang, XinFeng Yang, LuYi Zhang, YuXiao Ye, LiBing Fan, JianGang Wang, JianGang Wang, JianGang Wang, JianGang Wang   +14 more
doaj   +1 more source

Autoantibodies against retinal proteins in paraneoplastic and autoimmune retinopathy [PDF]

, 2004
BACKGROUND: Autoimmune retinal degeneration may occur in patients who present with sudden or, less commonly, subacute loss of vision of retinal origin, associated with an abnormal ERG, through the action of autoantibodies against retinal proteins.
AH Milam, B Lei, CE Thirkill, DM Jacobson, G Adamus, G Adamus, G Adamus, G Adamus, G Adamus, G Adamus, G Adamus, G Ren, G Tezel, Gaoying Ren, Grazyna Adamus, H Ohguro, H Ohguro, I Maruyama, JB Mizener, JL Keltner, JL Keltner, JL Keltner, JR Heckenlively, MA Murphy, MJ Potter, MR Stanford, MS Savchenko, R Peek, R Peek, Richard G Weleber, SM Whitcup, YH Yoon   +31 more
core   +3 more sources

Expression and Function of IL12/23 Related Cytokine Subunits (p35, p40, and p19) in Giant-Cell Arteritis Lesions: Contribution of p40 to Th1- and Th17-Mediated Inflammatory Pathways

Frontiers in Immunology, 2018
Background Giant-cell arteritis (GCA) is considered a T helper (Th)1- and Th17-mediated disease. Interleukin (IL)-12 is a heterodimeric cytokine (p35/p40) involved in Th1 differentiation. When combining with p19 subunit, p40 compose IL-23, a powerful pro-
G. Espígol-Frigolé, E. Planas-Rigol, E. Lozano, M. Corbera-Bellalta, Nekane Terrades-García, S. Prieto-González, A. García-Martínez, J. Hernández-Rodríguez, J. Grau, M. Cid   +9 more
semanticscholar   +1 more source

Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide⁺

BMC Cancer, 2010
Background Cytochrome P450-based suicide gene therapy for cancer using prodrugs such as cyclophosphamide (CPA) increases anti-tumor activity, both directly and via a bystander killing mechanism.
Doloff Joshua C, Su Ting, Waxman David J
doaj   +1 more source

Focusing on cyclin-dependent kinases 5: A potential target for neurological disorders

Frontiers in Molecular Neuroscience, 2022
Cyclin-dependent kinases 5 (Cdk5) is a special member of proline-directed serine threonine kinase family. Unlike other Cdks, Cdk5 is not directly involved in cell cycle regulation but plays important roles in nervous system functions. Under physiological
Zhen Tian, Bin Feng, Xing-Qin Wang, Jiao Tian   +3 more
doaj   +1 more source

Tissue-type plasminogen activator regulates p35-mediated Cdk5 activation in the postsynaptic terminal

Journal of Cell Science, 2019
Neuronal depolarization induces the synaptic release of tissue-type plasminogen activator (tPA). Cyclin-dependent kinase-5 (Cdk5) is a member of the family of cyclin-dependent kinases that regulates cell migration and synaptic function in postmitotic ...
Ariel Diaz, V. Jeanneret, Paola Merino, Patrick McCann, M. Yepes   +4 more
semanticscholar   +1 more source

TFP5 peptide, derived from CDK5-activating cofactor p35, provides neuroprotection in early-stage of adult ischemic stroke

Scientific Reports, 2017
Cyclin-dependent kinase 5 (CDK5) is a multifaceted protein shown to play important roles in the central nervous system. Abundant evidence indicates that CDK5 hyperactivities associated with neuronal apoptosis and death following ischemic stroke.
Ya-bin Ji, Pei-Pei Zhuang, Z. Ji, Yongming Wu, Yong Gu, Xiao-Ya Gao, S. Pan, Yafang Hu   +7 more
semanticscholar   +1 more source

Neuron-Specific Menin Deletion Leads to Synaptic Dysfunction and Cognitive Impairment by Modulating p35 Expression

Cell Reports, 2018
Summary: Menin (MEN1) is a critical modulator of tissue development and maintenance. As such, MEN1 mutations are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome.
Kai Zhuang, Changquan Huang, Lige Leng, Honghua Zheng, Yuehong Gao, Guimiao Chen, Zhilin Ji, Hao Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Guojun Bu, Timothy Y. Huang, Huaxi Xu, Jie Zhang   +18 more
doaj   +1 more source

Distribution of winners in truel games [PDF]

, 2005
In this work we present a detailed analysis using the Markov chain theory of some versions of the truel game in which three players try to eliminate each other in a series of one-to-one competitions, using the rules of the game.
Amengual, P., Toral, R.
core   +3 more sources