Results 31 to 40 of about 67,493 (202)
Sumoylation of p35 Modulates p35/Cyclin-Dependent Kinase (Cdk) 5 Complex Activity
NeuroMolecular Medicine, 2014 Cyclin-dependent kinase (Cdk) 5 is critical for central nervous system development and neuron-specific functions including neurite outgrowth as well as synaptic function and plasticity. Cdk5 activity requires association with one of the two regulatory subunits, called p35 and p39. p35 redistribution as well as misregulation of Cdk5 activity is followed
Büchner, A. +5 more
openaire +3 more sources
Acta Neuropathologica Communications, 2019 Cyclin dependent kinase-5 (cdk5)/p35 is a neuronal kinase that regulates key axonal and synaptic functions but the mechanisms by which it is transported to these locations are unknown. Lemur tyrosine kinase-2 (LMTK2) is a binding partner for p35 and here
Gábor M. Mórotz +8 more
doaj +1 more source
Cells, 2021 Cyclin-dependent kinase 5 (Cdk5) is expressed in terminally differentiated cells, where it drives development, morphogenesis, and survival. Temporal and spatial kinase activity is regulated by specific activators of Cdk5, dependent on the cell type and ...
Nicole Mangold +9 more
doaj +1 more source
Journal of Biomedical Science, 2021 Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular processes in neurons, the dysregulation of which compromises normal brain function.
Ping-Chieh Pao, Li-Huei Tsai
doaj +1 more source
A framework for security requirements engineering [PDF]
, 2006 This paper presents a framework for security requirements elicitation and analysis, based upon the construction of a context for the system and satisfaction arguments for the security of the system. One starts with enumeration of security goals based on
Haley, Charles B. +3 more
core +1 more source
CDK5: an oncogene or an anti-oncogene: location location location
Molecular Cancer, 2023 Recent studies have uncovered various physiological functions of CDK5 in many nonneuronal tissues. Upregulation of CDK5 and/or its activator p35 in neurons promotes healthy neuronal functions, but their overexpression in nonneuronal tissues is causally ...
Kumar Nikhil, Kavita Shah
doaj +1 more source
Biometric responses to music-rich segments in films: the CDVPlex [PDF]
, 2009 Summarising or generating trailers for films or movies involves finding the highlights within those films, those segments where we become most afraid, happy, sad, annoyed, excited, etc.
Rothwell, Sandra, Smeaton, Alan F.
core +2 more sources
Localized JNK signaling regulates organ size during development. [PDF]
, 2016 A fundamental question of biology is what determines organ size. Despite demonstrations that factors within organs determine their sizes, intrinsic size control mechanisms remain elusive.
Beachy, Philip A +5 more
core +3 more sources
Contribution of IL-12/IL-35 common subunit p35 to maintaining the testicular immune privilege.
PLoS ONE, 2014 The testis is an organ with immune privilege. The comprehensive blood-testis barrier formed by Sertoli cells protects autoimmunogenic spermatozoa and spermatids from attack by the body's immune system. The interleukin (IL)-6/IL-12 family cytokines IL-12 (
Hayato Terayama +15 more
doaj +1 more source
Expression of baculovirus P35 prevents cell death in Drosophila [PDF]
, 1994 The baculovirus P35 protein functions to prevent apoptotic death of infected cells. We have expressed P35 in the developing embryo and eye of the fly Drosophila melanogaster. P35 eliminates most, if not all, normally occurring cell death in these tissues,
Hay, Bruce A. +2 more
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