Results 41 to 50 of about 67,493 (202)
Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon +12 more
wiley +1 more source
Oncolytic adenovirus expressing IL-23 and p35 elicits IFN-γ- and TNF-α-co-producing T cell-mediated antitumor immunity. [PDF]
PLoS ONE, 2013 Cytokine immunogene therapy is a promising strategy for cancer treatment. Interleukin (IL)-12 boosts potent antitumor immunity by inducing T helper 1 cell differentiation and stimulating cytotoxic T lymphocyte and natural killer cell cytotoxicity.
Il-Kyu Choi +4 more
doaj +1 more source
Cyclin Dependent Kinase 5 in Endothelial Cell Migration [PDF]
, 2010 Cyclin dependent kinase 5 (Cdk5) is studied to take part in the migration neurons and development of brain. It is proven to participate also in the mediation of endothelial cell migration and angiogenesis.
Heiskanen, Suvi
core
Normal forms for Kummer surfaces
, 2019 We determine normal forms for the Kummer surfaces associated with abelian surfaces of polarization of type $(1,1)$, $(1,2)$, $(2,2)$, $(2,4)$, and $(1,4)$.
Clingher, Adrian, Malmendier, Andreas
core +1 more source
Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. [PDF]
, 2009 The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain.
Green, Kim N
core +1 more source
Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas +39 more
wiley +1 more source
Neurobiology of Disease, 2003 Neuronal excitotoxicity causes energetic impairment and the ensuing cell death has historically been regarded as necrotic. Recent findings, however, indicate that apoptosis may participate in excitotoxicity.
Madhuri Roy, Robert M Sapolsky
doaj +1 more source
Holomorphic subgraph reduction of higher-point modular graph forms
, 2019 Modular graph forms are a class of modular covariant functions which appear in the genus-one contribution to the low-energy expansion of closed string scattering amplitudes.
Gerken, Jan E., Kaidi, Justin
core +1 more source
Backbone Heterojunction Photocatalysts for Efficient Sacrificial Hydrogen Production
Advanced Functional Materials, EarlyView.Herein, a ‘single‐component’ organic semiconductor photocatalyst is presented in which a molecular donor is bonded to a polymer acceptor. The resultant material demonstrates exceptional photocatalytic activity for hydrogen evolution in aqueous triethylamine with an outstanding external quantum efficiency of 38% at 420 nm.
Richard J. Lyons +11 more
wiley +1 more source
Ocular expression of cyclin‐dependent kinase 5 in patients with proliferative diabetic retinopathy
Journal of Diabetes Investigation, 2022 Aims/Introduction Inhibition of peroxisome proliferator‐activated receptor gamma (PPARγ) phosphorylation mediated by cyclin‐dependent kinase 5 (Cdk5) is one of the main mechanisms of action of antidiabetic drugs.
Hiroki Sano +6 more
doaj +1 more source