Results 41 to 50 of about 76,399 (242)
Journal of Neuroscience, 2016 The regulation of oligodendrocyte development and myelin formation in the CNS is poorly defined. Multiple signals influence the rate and extent of CNS myelination, including the noncanonical cyclin-dependent kinase 5 (Cdk5) whose functions are regulated ...
Fucheng Luo +4 more
semanticscholar +1 more source
Acta Universitatis Sapientiae: Economics and Business, 2023 This study tries to empirically estimate the effects of the composition of intergovernmental transfers on tax collection across the Indian states by using panel regression model.
Kumar Sumit, Kaur Baljit
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2022 Existing studies have revealed that microRNAs (miRNAs) have a role in cognitive deficits in Alzheimer’s disease (AD). However, the function and pathophysiological mechanism of deregulated miRNAs underlying AD pathology remain to be investigated.
Li Zeng +8 more
doaj +1 more source
A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration [PDF]
, 2012 Axonal degeneration is a molecular self-destruction cascade initiated following traumatic, toxic, and metabolic insults. Its mechanism underlies a number of disorders including hereditary and diabetic neuropathies and the neurotoxic side effects of ...
Bhattacharya, Martha R.C. +7 more
core +2 more sources
Journal of Biomedical Science, 2021 Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular processes in neurons, the dysregulation of which compromises normal brain function.
Ping-Chieh Pao, Li-Huei Tsai
doaj +1 more source
Cells, 2021 Cyclin-dependent kinase 5 (Cdk5) is expressed in terminally differentiated cells, where it drives development, morphogenesis, and survival. Temporal and spatial kinase activity is regulated by specific activators of Cdk5, dependent on the cell type and ...
Nicole Mangold +9 more
doaj +1 more source
A framework for security requirements engineering [PDF]
, 2006 This paper presents a framework for security requirements elicitation and analysis, based upon the construction of a context for the system and satisfaction arguments for the security of the system. One starts with enumeration of security goals based on
Haley, Charles B. +3 more
core +1 more source
CDK5: an oncogene or an anti-oncogene: location location location
Molecular Cancer, 2023 Recent studies have uncovered various physiological functions of CDK5 in many nonneuronal tissues. Upregulation of CDK5 and/or its activator p35 in neurons promotes healthy neuronal functions, but their overexpression in nonneuronal tissues is causally ...
Kumar Nikhil, Kavita Shah
doaj +1 more source
Journal of Neuroscience, 2016 Inhibitory molecules associated with CNS myelin, such as myelin-associated glycoprotein (MAG), represent major obstacles to axonal regeneration following CNS injury. Our laboratory has shown that elevating levels of intracellular cAMP, via application of
Huifang He +6 more
semanticscholar +1 more source
Localized JNK signaling regulates organ size during development. [PDF]
, 2016 A fundamental question of biology is what determines organ size. Despite demonstrations that factors within organs determine their sizes, intrinsic size control mechanisms remain elusive.
Beachy, Philip A +5 more
core +3 more sources