Results 61 to 70 of about 67,493 (202)
Frontiers in Cellular Neuroscience, 2018 p35 is an activating co-factor of Cyclin-dependent kinase 5 (Cdk5), a protein whose dysfunction has been implicated in a wide-range of neurological disorders including cognitive impairment and disease.
Eriko Kamiki +5 more
doaj +1 more source
A Model to Explain How the Bacille Calmette Guérin (BCG) Vaccine Drives Interleukin-12 Production in Neonates. [PDF]
PLoS ONE, 2016 The Bacille Calmette Guérin (BCG) vaccine is the only routine vaccination at birth that effectively induces neonatal T-helper 1 (Th1)-polarized immune responses. The primary cytokine that drives CD4+ T-cell Th1 differentiation is interleukin (IL)-12 p70,
Chido Loveness Kativhu, Daniel H Libraty
doaj +1 more source
The One-Loop Five-Graviton Scattering Amplitude and Its Low-Energy Limit
, 1992 A covariant path integral calculation of the even spin structure contribution to the one-loop N-graviton scattering amplitude in the type-II superstring theory is presented. The apparent divergence of the $N=5$ amplitude is resolved by separating it into
Amano +10 more
core +2 more sources
Generating a host range-expanded recombinant baculovirus [PDF]
, 2016 Citation: Wu, C. F., Deng, Z. H., Long, Z., Cai, Y., Ying, Z. F., Yin, H. Q., . . . Pang, Y. (2016). Generating a host range-expanded recombinant baculovirus. Scientific Reports, 6, 14.
Cai, Y. +9 more
core +1 more source
Developmental Dynamics, EarlyView.Abstract Background Robinow syndrome is a rare developmental syndrome caused by variants in genes in Wnt signaling pathways. We previously showed that expression of patient variants in Dishevelled 1 (DVL1) in Drosophila and chicken models disrupts the balance of canonical and non‐canonical Wnt signaling.
Gamze Akarsu +4 more
wiley +1 more source
Neurosignals, 2012 Cyclin-dependent kinase 5 (Cdk5), a member of the cyclin-dependent kinase family, is critical for regulating neural development and neuronal survival.
Amy K.Y. Fu +4 more
doaj +1 more source
Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]
, 2004 Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Bouloux, PM +8 more
core +1 more source
Epilepsia, EarlyView.Abstract Objective A strong bidirectional relationship exists between epilepsy and sleep, with seizures often occurring more frequently in sleep and, in turn, sleep being disrupted by seizures. However, the mechanistic basis of seizure–sleep interactions is poorly understood.
Nicholas R. Rensing +4 more
wiley +1 more source
Disease Models & Mechanisms, 2018 Aging is the greatest risk factor for neurodegeneration, but the connection between the two processes remains opaque. This is in part for want of a rigorous way to define physiological age, as opposed to chronological age.
Joshua Spurrier +4 more
doaj +1 more source
Dysregulation of NAD+ metabolism induces a Schwann cell dedifferentiation program [PDF]
, 2018 The Schwann cell (SC) is the major component of the peripheral nervous system (PNS) that provides metabolic and functional support for peripheral axons. The emerging roles of SC mitochondrial function for PNS development and axonal stability indicate the
Hackett, Amber R +4 more
core +1 more source