Results 71 to 80 of about 76,399 (242)

Dysregulation of NAD+ metabolism induces a Schwann cell dedifferentiation program [PDF]

, 2018
The Schwann cell (SC) is the major component of the peripheral nervous system (PNS) that provides metabolic and functional support for peripheral axons. The emerging roles of SC mitochondrial function for PNS development and axonal stability indicate the
Hackett, Amber R, Kim, Sungsu, Milbrandt, Jeffrey, Sasaki, Yo, Strickland, Amy   +4 more
core   +1 more source

The One-Loop Five-Graviton Scattering Amplitude and Its Low-Energy Limit

, 1992
A covariant path integral calculation of the even spin structure contribution to the one-loop N-graviton scattering amplitude in the type-II superstring theory is presented. The apparent divergence of the $N=5$ amplitude is resolved by separating it into
Amano, D'Hoker, Frampton, Hooft, J. Lee Montag, Lam, Montag, Mumford, Namazie, Polchinski, Schwarz   +10 more
core   +2 more sources

Locomotor hyperactivity in 14-3-3Zeta KO mice is associated with dopamine transporter dysfunction [PDF]

, 2013
Dopamine (DA) neurotransmission requires a complex series of enzymatic reactions that are tightly linked to catecholamine exocytosis and receptor interactions on pre- and postsynaptic neurons.
A Abi-Dargham, A Aitken, A Breier, A Vina-Vilaseca, AA Williams, AH Wong, B Giros, B Giros, BL Summers, BT Baune, C Itagaki, CA Tamminga, D Berg, D Sulzer, DL Levy, FA Middleton, H Fu, H Jaaro-Peled, H Khoshbouei, H Koike, HC Baxter, J Sun, J Wang, JA English, JA English, JA Lieberman, JA Lieberman, JH Son, JM van Rossum, K Toska, K Toyo-oka, K Toyo-Oka, KL Holton, M Laruelle, M Laruelle, M Miranda, M Rosner, M van den Buuse, M van den Buuse, MS Samuel, O Halskau Jr., P Coyle, PC Hart, PS Cheah, S Leucht, S Sivagnanasundaram, S Sivagnanasundaram, SG Amara, SR Jones, T Ichimura, T Ichimura, WC Drevets, WT Carpenter, Y Jia   +53 more
core   +2 more sources

Robinow syndrome DVL1 variants disrupt morphogenesis and appendage formation in a Drosophila disease model

Developmental Dynamics, EarlyView.
Abstract Background Robinow syndrome is a rare developmental syndrome caused by variants in genes in Wnt signaling pathways. We previously showed that expression of patient variants in Dishevelled 1 (DVL1) in Drosophila and chicken models disrupts the balance of canonical and non‐canonical Wnt signaling.
Gamze Akarsu, Katja R. MacCharles, Kenneth Kin Lam Wong, Joy M. Richman, Esther M. Verheyen   +4 more
wiley   +1 more source

Altered expression of the Cdk5 activator-like protein, Cdk5α, causes neurodegeneration, in part by accelerating the rate of aging

Disease Models & Mechanisms, 2018
Aging is the greatest risk factor for neurodegeneration, but the connection between the two processes remains opaque. This is in part for want of a rigorous way to define physiological age, as opposed to chronological age.
Joshua Spurrier, Arvind Kumar Shukla, Kristina McLinden, Kory Johnson, Edward Giniger   +4 more
doaj   +1 more source

Cdk5 activation promotes Cos-7 cells transition towards neuronal-like cells

Translational Neuroscience, 2023
Cyclin-dependent kinase 5 (Cdk5) activity is specifically active in neurogenesis, and Cdk5 and neocortical neurons migration related biomarker are expressed in Cos-7 cells.
Bao Li, Lan Xiao-Mei, Zhang Guo-Qing, Bao Xi, Li Bo, Ma Dan-Na, Luo Hong-Yan, Cao Shi-Lu, Liu Shun-Yao, Jing E, Zhang Jian-Zhong, Zheng Ya-Li   +11 more
doaj   +1 more source

Generating a host range-expanded recombinant baculovirus [PDF]

, 2016
Citation: Wu, C. F., Deng, Z. H., Long, Z., Cai, Y., Ying, Z. F., Yin, H. Q., . . . Pang, Y. (2016). Generating a host range-expanded recombinant baculovirus. Scientific Reports, 6, 14.
Cai, Y., Clem, Rollie J., Deng, Z. H., Long, Z., Pang, Y., Wu, C. F., Yang, K., Yin, H. Q., Ying, Z. F., Yuan, M. J.   +9 more
core   +1 more source

Bidirectional sleep‐seizure interactions and orexin in a mouse model of tuberous sclerosis complex‐related epilepsy

Epilepsia, EarlyView.
Abstract Objective A strong bidirectional relationship exists between epilepsy and sleep, with seizures often occurring more frequently in sleep and, in turn, sleep being disrupted by seizures. However, the mechanistic basis of seizure–sleep interactions is poorly understood.
Nicholas R. Rensing, Lirong Han, Dongjun Guo, Thomas J. Foutz, Michael Wong   +4 more
wiley   +1 more source

“It's just us”: Families' experiences with temporary tube feeding

Nutrition in Clinical Practice, EarlyView.
Abstract Background Children with temporary feeding tubes are discharged home with increasing frequency, yet little is known about how families adapt and manage in their home environment. Whereas the physical side effects of temporary feeding tubes are well documented, the psychosocial impact on families remains underresearched. Understanding families'
Claire Reilly, Jeanne Marshall, Jasmine Foley, Nikhil Thapar, Rebecca Packer   +4 more
wiley   +1 more source

The decay omega(782) -> 5 pi in chiral theory

, 2000
The arguments are put forward that the many pion decays omega ->2 pi^+ 2 pi^- pi^0 and pi^+ pi^- 3 pi^0 provide an ideal test site for testing the predictions of chiral models of the vector meson decays into many pions.
A.A. Kozhevnikov, N.N. Achasov, Plant, Weinberg, Wess   +4 more
core   +2 more sources