Results 151 to 160 of about 1,900,236 (234)

Cumulus cells enhance oocyte genomic quality control by promoting DNA damage-induced meiotic arrest. [PDF]

J Cell Sci
Zhou C, McKinnon B, Homer H.
europepmc   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Human lungs maintain tissue-resident memory T cells against a broad spectrum of pathogens. [PDF]

Nat Immunol
Fajardo-Rosas V, Ehtram A, Marchand-Casas I, Chee SJ, Mondal M, Ferrández Alaminos C, Castañeda-Castro FE, Roy Z, Chudley L, Shackcloth M, Cave J, Alzetani A, Woo E, Phillips E, Mallal S, Grifoni A, Schmiedel BJ, Sette A, Peters B, Ottensmeier CH, Vijayanand P.   +20 more
europepmc   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

HLA-II Expression Marks Activated and Clonally Expanded CD8⁺ T Cells and Improves Tumor-Reactivity Prediction Across Human Cancers. [PDF]

Int J Mol Sci
Mi X, Zhu J, Dai Z, Yang R, Tian D, Cao G, Xiao Z.   +6 more
europepmc   +1 more source

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source

Niche-specific immune and microbial signatures across the healthy upper respiratory tract mucosa. [PDF]

iScience
Kardomatea N, Kool J, Nicolaie MA, van Dijken H, Reinen E, Konstanti P, Eggink D, Jaarsma R, van Emst L, van Woudenbergh E, Ferreira JA, Fuentes S, de Jonge MI, de Jonge J, Verhagen LM, Hartog GD.   +15 more
europepmc   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Immunodominance hierarchy of influenza A haemagglutinin antigenic sites: an observational cohort study across distinct exposure histories. [PDF]

EBioMedicine
Martínez-Guevara JL, Lai TY, Mishra M, Hoang MT, Shea W, Page CK, Sinywimaanzi P, Simulundu E, Rothman RE, Pekosz A, Joan Fenstermacher KZ, Sutcliffe CG, Simon V, Palese P, Sun W, González-Domínguez I.   +15 more
europepmc   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source