Results 161 to 170 of about 1,900,236 (234)

Proinflammatory Epstein-Barr Virus Antibody Functions Track with Disease Activity in Multiple Sclerosis. [PDF]

Ann Neurol
Behrens M, Terroba-Navajas P, Willemse EAJ, Schädelin S, Comabella M, Münz C, Lauc G, Bartsch Y, Kuhle J, Lünemann JD.   +9 more
europepmc   +1 more source

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

Reproducible detection of antigen-specific T cells and Tregs via standardized and automated activation-induced marker assay workflows. [PDF]

Cell Rep Methods
Halvorson T, Boucher G, Yokosawa D, Huang JQ, Garcia R, Sanderink L, Chen L, Liu L, Fajardo-Despaigne JE, Halvorson J, Brinkman R, Vercauteren S, Lesage S, Bramson J, Rioux JD, Ivison S, Levings MK.   +16 more
europepmc   +1 more source

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

Phylogenetic analysis of amino acid sequences indicates a central role of transmembrane domain structural elements in MHC class II function. [PDF]

J Immunol
Karathanou K, Duke JL, Cangialosi SM, Marlow L, Dixon AM, Monos DS, Drake JR.   +6 more
europepmc   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Donor-Derived Cell-Free DNA Levels Predict Renal Allograft Biopsy Findings in a UK Single-Centre Study. Results of the KORAD Study. [PDF]

Int J Immunogenet
Flynn PA, Rutter MK, Burlinson ND.
europepmc   +1 more source

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Characterization of B cell activation and spatial distribution in the tumor microenvironment of high-grade serous ovarian cancer. [PDF]

Transl Oncol
Capezzali E, Arcieri M, Tonon S, Ricci C, Valeri V, Restaino S, Driul L, Gomba B, Pregnolato S, Mangogna A, Mariuzzi L, Tulisso A, Orsaria M, Andreetta C, Pucillo C, Vizzielli G, Frossi B.   +16 more
europepmc   +1 more source