Results 1 to 10 of about 34,810 (187)

Global, site-specific analysis of neuronal protein S-acylation [PDF]

Scientific Reports, 2017
Protein S-acylation (palmitoylation) is a reversible lipid modification that is an important regulator of dynamic membrane-protein interactions. Proteomic approaches have uncovered many putative palmitoylated proteins however, methods for comprehensive ...
Mark O. Collins, Keith T. Woodley, Jyoti S. Choudhary   +2 more
doaj   +2 more sources

Palmitoylation of Plasmodium alveolins promotes cytoskeletal function. [PDF]

, 2017
S-palmitoylation is a post-translational lipid modification that is widespread among Plasmodium proteins and essential for parasite development. Little is known about the contribution of palmitoylation to the function of individual parasite molecules and
Al-Khattaf, Fatimah S, Dessens, Johannes T, Tremp, Annie Z   +2 more
core   +3 more sources

Mechanistic role of CD82 palmitoylation in augmenting antitumor drug sensitivity via apoptosis regulation [PDF]

Frontiers in Oncology
IntroductionCD82, a metastasis suppressor, is known to be palmitoylated, yet the functional significance of this modification in drug response remains unclear.
Lanyan Li, Yaning Yu, Sirui Chen, Yihuan Zhang, Can Zhang, Xinyu Yao, Hongli Xu, Shihao Wu, Xue Gong, Weiping Han, Yu Zhang, Ying Li   +11 more
doaj   +2 more sources

Temporal and protein-specific S-palmitoylation supports synaptic and neural network plasticity [PDF]

Cellular and Molecular Life Sciences
Background Synaptic plasticity, a fundamental process underlying learning and memory, depends on activity-driven changes in neural connectivity. S-palmitoylation, a reversible post-translational lipid modification, modulates synaptic protein function by ...
Agata Pytyś, Rabia Ijaz, Anna Buszka, Jacek Miłek, Izabela Figiel, Patrycja Wardaszka-Pianka, Matylda Roszkowska, Natalia Mierzwa, Adam Wojtas, Eli Kerstein, Remigiusz Serwa, Katarzyna Kalita, Rhonda Dzakpasu, Magdalena Dziembowska, Jakub Włodarczyk, Tomasz Wójtowicz   +15 more
doaj   +2 more sources

Inhibition of DHHC9-mediated CD36 palmitoylation lessens high-fat diet (HFD)-induced impairment of pubertal mammary gland development through the JNK-ERK pathway [PDF]

Cellular & Molecular Biology Letters
Background CD36, a vital fatty acid translocase, has been reported to participate in multiple physiological functions through palmitoylation mediated by zinc finger Asp–His–His–Cys-type palmitoyltransferases (DHHCs).
Yiming Fu, Fenglin Zhang, Limin Lang, Shuyi Liang, Junfeng Wang, Shilei Zhang, Kaixin Deng, Jinhao Liu, Lilin Cai, Yue Zhang, Lidong Yan, Guo Ren, Haoyan Kang, Lina Wang, Canjun Zhu, Ruifan Wu, Gang Shu, Qingyan Jiang, Songbo Wang   +18 more
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Crosstalk of Synapsin1 palmitoylation and phosphorylation controls the dynamicity of synaptic vesicles in neurons

Cell Death and Disease, 2022
The dynamics of synaptic vesicles (SVs) within presynaptic domains are tightly controlled by synapsin1 phosphorylation; however, the mechanism underlying the anchoring of synapsin1 with F-actin or SVs is not yet fully understood. Here, we found that Syn1
Peipei Yan, Huicong Liu, Tao Zhou, Pu Sun, Yilin Wang, Xibin Wang, Lin Zhang, Tian Wang, Jing Dong, Jiangli Zhu, Luxian Lv, Wenqiang Li, Shiqian Qi, Yinming Liang, Eryan Kong   +14 more
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Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis

Journal of Translational Medicine, 2023
Background Protein palmitoylation, which is catalyzed by palmitoyl-transferase and de-palmitoyl-transferase, plays a crucial role in various biological processes. However, the landscape and dynamics of protein palmitoylation in human cancers are not well
Yue Kong, Yugeng Liu, Xianzhe Li, Menglan Rao, Dawei Li, Xiaolan Ruan, Shanglin Li, Zhenyou Jiang, Qiang Zhang   +8 more
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Diverse Roles of Protein Palmitoylation in Cancer Progression, Immunity, Stemness, and Beyond

Cells, 2023
Protein S-palmitoylation, a type of post-translational modification, refers to the reversible process of attachment of a fatty acyl chain—a 16-carbon palmitate acid—to the specific cysteine residues on target proteins.
Mingli Li, Leisi Zhang, Chun-Wei Chen
doaj   +1 more source

Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies

Frontiers in Physiology, 2022
S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date.
Alice Main, Andri Boguslavskyi, Jacqueline Howie, Chien-Wen Kuo, Aileen Rankin, Francis L. Burton, Godfrey L. Smith, Roger Hajjar, George S. Baillie, Kenneth S. Campbell, Michael J. Shattock, William Fuller   +11 more
doaj   +1 more source

PPT1 regulation of HSP90α depalmitoylation participates in the pathogenesis of hyperandrogenism

iScience, 2023
Summary: Ovarian granulosa cells (GCs) in the follicle are the important mediator of steroidogenesis and foster oocyte maturation. Evidences suggested that the function of GCs could be regulated by S-palmitoylation.
Tongmin Xue, Shanmeizi Zhao, Hong Zhang, Ting Tang, Lu Zheng, Jun Jing, Xie Ge, Rujun Ma, Jinzhao Ma, Xiaoyan Ren, Kadiliya Jueraitetibaike, Zhigang Guo, Li Chen, Bing Yao   +13 more
doaj   +1 more source