Results 1 to 10 of about 34,702 (278)

Recent advances in S-palmitoylation and its emerging roles in human diseases

Journal of Hematology & Oncology
S-palmitoylation, one reversible post-translational modification (PTM) involving the binding of palmitate to proteins, influences protein stability, localization and interactions.
Juanjuan Shang, Mei Ding, Xiangxiang Zhou   +2 more
doaj   +1 more source

Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironment

Frontiers in Immunology
Protein S-palmitoylation is a reversible post-translational lipid modification that involves the addition of a 16-carbon palmitoyl group to a protein cysteine residue via a thioester linkage.
Yijiao Chen, Yongsheng Li, Lei Wu
doaj   +1 more source

Palmitoylation of ACE2 at Cys141, Cys344, and Cys498 facilitates its extracellular vesicles localization [PDF]

Jichu yixue yu linchuang
Objective To identify S-palmitoylation sites on angiotensin-converting enzyme 2(ACE2), the cellular receptor for severe acute respiratory syndrome corona virus(SARS-CoV) and SARS-CoV-2, and to investigate the functional relevance of these modifications ...
YANG Jingjing, MA Yan, WANG Yue, SUN Yang, LI Pan, GUO Feng
doaj   +1 more source

Inhibiting S-palmitoylation arrests metastasis by relocating Rap2b from plasma membrane in colorectal cancer

Cell Death and Disease
Rap2b, a proto-oncogene upregulated in colorectal cancer (CRC), undergoes protein S-palmitoylation at specific C-terminus sites (C176/C177). These palmitoylation sites are crucial for Rap2b localization on the plasma membrane (PM), as mutation of C176 or
Jiangli Zhu, Xize Cao, Zhenshuai Chen, Birou Lai, Lingling Xi, Jinghang Zhang, Shaohui Zhu, Shiqian Qi, Yinming Liang, Fei Cao, Binhui Zhou, Yu Song, Sheng Jiang, Tianyu Wang, Xiaohong Kang, Eryan Kong   +15 more
doaj   +1 more source

A novel yeast-based high-throughput method for the identification of protein palmitoylation inhibitors

Open Biology, 2021
Protein S-acylation or palmitoylation is a widespread post-translational modification that consists of the addition of a lipid molecule to cysteine residues of proteins through a thioester bond.
Consuelo Coronel Arrechea, María Luz Giolito, Iris Alejandra García, Gastón Soria, Javier Valdez Taubas   +4 more
doaj   +1 more source

Potential Role of S-Palmitoylation in Cancer Stem Cells of Lung Adenocarcinoma [PDF]

, 2021
Yitong Zhang, Fenglan Li, Kexin Fu, Xiqing Liu, I-Chia Lien, Hui Li   +5 more
openalex   +1 more source

The CP123L protein of African swine fever virus is a membrane-associated, palmitoylated protein required for viral replication

Journal of Virology
African swine fever (ASF) is a highly contagious and often lethal disease caused by African swine fever virus (ASFV) in pigs. Protein palmitoylation is a prevalent posttranslational lipid modification that can modulate viral replication.
Xiangyu Guan, Tao Wang, Yuxuan Gao, Huanjie Zhai, Fengwei Jiang, Qinghe Hou, Xiaoke Yang, Hongxia Wu, Lian-Feng Li, Yuzi Luo, Su Li, Yuan Sun, Hua-Ji Qiu, Yongfeng Li   +13 more
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Curcumin Prevents Palmitoylation of Integrin β4 in Breast Cancer Cells. [PDF]

PLoS ONE, 2015
Curcumin has been shown to mitigate cancer phenotypes such as invasive migration, proliferation, and survival by disrupting numerous signaling pathways.
David T Coleman, Young Hwa Soung, Young-Joon Surh, James A Cardelli, Jun Chung   +4 more
doaj   +1 more source

Coordinated interplay between palmitoylation, phosphorylation and SUMOylation regulates kainate receptor surface expression [PDF]

, 2023
Busra P. Yucel, Enaam Al Momany, Ashley J. Evans, Richard Seager, Kevin A. Wilkinson, Jeremy M. Henley   +5 more
openalex   +3 more sources

Protein palmitoylation is involved in regulating mouse sperm motility via the signals of calcium, protein tyrosine phosphorylation and reactive oxygen species

Biological Research
Background Protein palmitoylation, a critical posttranslational modification, plays an indispensable role in various cellular processes, including the regulation of protein stability, mediation of membrane fusion, facilitation of intracellular protein ...
Yuping Xiong, Chenchen Yi, Haixia Zheng, Ya Ni, Yamei Xue, Kun Li   +5 more
doaj   +1 more source