Results 11 to 20 of about 34,702 (278)

Global, site-specific analysis of neuronal protein S-acylation [PDF]

Scientific Reports, 2017
Protein S-acylation (palmitoylation) is a reversible lipid modification that is an important regulator of dynamic membrane-protein interactions. Proteomic approaches have uncovered many putative palmitoylated proteins however, methods for comprehensive ...
Mark O. Collins, Keith T. Woodley, Jyoti S. Choudhary   +2 more
doaj   +2 more sources

Mechanistic role of CD82 palmitoylation in augmenting antitumor drug sensitivity via apoptosis regulation [PDF]

Frontiers in Oncology
IntroductionCD82, a metastasis suppressor, is known to be palmitoylated, yet the functional significance of this modification in drug response remains unclear.
Lanyan Li, Yaning Yu, Sirui Chen, Yihuan Zhang, Can Zhang, Xinyu Yao, Hongli Xu, Shihao Wu, Xue Gong, Weiping Han, Yu Zhang, Ying Li   +11 more
doaj   +2 more sources

Palmitoylation of Plasmodium alveolins promotes cytoskeletal function [PDF]

, 2017
S-palmitoylation is a post-translational lipid modification that is widespread among Plasmodium proteins and essential for parasite development. Little is known about the contribution of palmitoylation to the function of individual parasite molecules and
Annie Z. Tremp, Fatimah S. Al-Khattaf, Johannes T. Dessens   +2 more
openalex   +4 more sources

Crosstalk of Synapsin1 palmitoylation and phosphorylation controls the dynamicity of synaptic vesicles in neurons

Cell Death and Disease, 2022
The dynamics of synaptic vesicles (SVs) within presynaptic domains are tightly controlled by synapsin1 phosphorylation; however, the mechanism underlying the anchoring of synapsin1 with F-actin or SVs is not yet fully understood. Here, we found that Syn1
Peipei Yan, Huicong Liu, Tao Zhou, Pu Sun, Yilin Wang, Xibin Wang, Lin Zhang, Tian Wang, Jing Dong, Jiangli Zhu, Luxian Lv, Wenqiang Li, Shiqian Qi, Yinming Liang, Eryan Kong   +14 more
doaj   +1 more source

Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation [PDF]

Nature, 2008
Palmitoylation regulates diverse aspects of neuronal protein trafficking and function. Here a global characterization of rat neural palmitoyl-proteomes identifies most of the known neural palmitoyl proteins-68 in total, plus more than 200 new palmitoyl-protein candidates, with further testing confirming palmitoylation for 21 of these candidates.
Kang, Rujun, Wan, Junmei, Arstikaitis, Pamela, Takahashi, Hideto, Huang, Kun, Bailey, Aaron O., Thompson, James X., Roth, Amy F., Drisdel, Renaldo C., Mastro, Ryan, Green, William N., Yates, John R., Davis, Nicholas G., El-Husseini, Alaa   +13 more
openaire   +2 more sources

Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis

Journal of Translational Medicine, 2023
Background Protein palmitoylation, which is catalyzed by palmitoyl-transferase and de-palmitoyl-transferase, plays a crucial role in various biological processes. However, the landscape and dynamics of protein palmitoylation in human cancers are not well
Yue Kong, Yugeng Liu, Xianzhe Li, Menglan Rao, Dawei Li, Xiaolan Ruan, Shanglin Li, Zhenyou Jiang, Qiang Zhang   +8 more
doaj   +1 more source

Diverse Roles of Protein Palmitoylation in Cancer Progression, Immunity, Stemness, and Beyond

Cells, 2023
Protein S-palmitoylation, a type of post-translational modification, refers to the reversible process of attachment of a fatty acyl chain—a 16-carbon palmitate acid—to the specific cysteine residues on target proteins.
Mingli Li, Leisi Zhang, Chun-Wei Chen
doaj   +1 more source

Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies

Frontiers in Physiology, 2022
S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date.
Alice Main, Andri Boguslavskyi, Jacqueline Howie, Chien-Wen Kuo, Aileen Rankin, Francis L. Burton, Godfrey L. Smith, Roger Hajjar, George S. Baillie, Kenneth S. Campbell, Michael J. Shattock, William Fuller   +11 more
doaj   +1 more source

PPT1 regulation of HSP90α depalmitoylation participates in the pathogenesis of hyperandrogenism

iScience, 2023
Summary: Ovarian granulosa cells (GCs) in the follicle are the important mediator of steroidogenesis and foster oocyte maturation. Evidences suggested that the function of GCs could be regulated by S-palmitoylation.
Tongmin Xue, Shanmeizi Zhao, Hong Zhang, Ting Tang, Lu Zheng, Jun Jing, Xie Ge, Rujun Ma, Jinzhao Ma, Xiaoyan Ren, Kadiliya Jueraitetibaike, Zhigang Guo, Li Chen, Bing Yao   +13 more
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source