Results 21 to 30 of about 39,498 (303)

ZDHHC7-mediated S -palmitoylation of ATG16L1 facilitates LC3 lipidation and autophagosome formation [PDF]

Autophagy
Macroautophagy/autophagy is a fundamental cellular catabolic process that delivers cytoplasmic components into double-membrane vesicles called autophagosomes, which then fuse with lysosomes and their contents are degraded.
Fujing Wei, Yu Wang, Jia Yao, Ligang Mei, Xue Huang, Hesheng Kong, Jing Chen, Xiaorong Chen, Lu Liu, Zhuolin Wang, Jiaxin Wang, Jiong Song, Eryan Kong, Aimin Yang   +13 more
openalex   +2 more sources

Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of G(i)- and G(q)-mediated signaling [PDF]

, 1999
RGS proteins (Regulators of G protein Signaling) are a recently discovered family of proteins that accelerate the GTPase activity of heterotrimeric G protein α subunits of the i, q, and 12 classes.
Backlund, Peter S., Caron, Joan M., Chen, Ching-Kang, Druey, Kirk M., Jones, Teresa L. Z., Ugur, Ozlem   +5 more
core   +1 more source

Identification of Giardia lamblia DHHC Proteins and the Role of Protein S-palmitoylation in the Encystation Process [PDF]

, 2014
Protein S-palmitoylation, a hydrophobic post-translational modification, is performed by protein acyltransferases that have a common DHHC Cys-rich domain (DHHC proteins), and provides a regulatory switch for protein membrane association. In this work, we
A Criscuolo, A Hiltpold, A Krogh, AB Hehl, AF Roth, AF Roth, AI Magee, Andrea S. Rópolo, B Eisenhaber, BC Jennings, BJ Davids, BJ Davids, BR Martin, BT Emmer, C Aicart-Ramos, C Aurrecoechea, C Faso, C Notredame, C Salaun, Cecilia V. Vranych, CH Sun, CH Sun, CH Wang, D Lloyd, DA Mitchell, DA Mitchell, DB Keister, DJ Bartels, DS Reiner, DS Reiner, EG Politis, F Abascal, FD Gillin, G DeJesus, GE Tusnady, GE Tusnady, HD Lujan, HD Lujan, HG Elmendorf, HG Morrison, I Letunic, I Letunic, I Slavin, J Greaves, J Greaves, J Greaves, J Pei, J Ren, J Schindelin, J Schultz, J Wan, J Yee, JA Duncan, JE Smotrys, JO Ebinu, JR Beck, JT Dunphy, K Frenal, KB Nicholas, KJ Livak, L Morf, LH Su, M Anisimova, M Fukata, M Punta, M Saric, María C. Merino, María C. Touz, MC Touz, MC Touz, MC Touz, MC Touz, MD Resh, ME Linder, ME Linder, MG De Napoli, ML Jones, ML Jones, MM Corvi, MM Zhang, MR Rivero, MS Brown, N Gottig, Nahuel Zamponi, O Batistic, O Rocks, P Papanastasiou, PG Carranza, R Tsutsumi, RD Adam, RD Finn, S Guindon, S Lobo, S Sonda, S Stoven, SE Boucher, SF Chuang, SL Planey, SM Singer, SR Birkeland, Steven M. Singer, T Hoppe, T Lauwaet, TE Nash, TE Nash, TN Petersen, TS Worgall, WF Leong, Y Fukata, Y He, Y Huang, Y Ohno, Y Webb, YC Huang, YJ Pan   +114 more
core   +3 more sources

Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors [PDF]

, 2019
The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are implicated in major depressive disorder (MDD). Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains, and identified ZDHHC21 as a major palmitoyl ...
Bazovkina, Daria, Bijata, Monika, Galil, Dalia Abdel, Gorinski, Nataliya, Kondaurova, Elena, Kulikova, Elizabeth [u.v.m.], Prasad, Sonal, Sigrist, Stephan, Wirth, Alexander, Zeug, Andre   +9 more
core   +1 more source

Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes β-catenin palmitoylation to drive colorectal cancer progression

Cell Discovery, 2023
Metabolic reprogramming is a hallmark of cancer. However, it is not well known how metabolism affects cancer progression. We identified that metabolic enzyme acyl-CoA oxidase 1 (ACOX1) suppresses colorectal cancer (CRC) progression by regulating palmitic
Qiang Zhang, Xiaoya Yang, Jinjie Wu, Shubiao Ye, Junli Gong, Wai Ming Cheng, Zhanhao Luo, Jing Yu, Yugeng Liu, Wanyi Zeng, Chen Liu, Zhizhong Xiong, Yuan Chen, Zhen He, P. Lan   +14 more
semanticscholar   +1 more source

ATP-independent Control of Vac8 Palmitoylation by a SNARE Subcomplex on Yeast Vacuoles [PDF]

, 2005
Yeast vacuole fusion requires palmitoylated Vac8. We previously showed that Vac8 acylation occurs early in the fusion reaction, is blocked by antibodies against Sec18 (yeast N-ethylmaleimide-sensitive fusion protein (NSF)), and is mediated by the R-SNARE
Cristodero, Marina, Dietrich, Lars E. P., LaGrassa, Tracy J., Meiringer, Christoph T. A., Rohde, Jan, Ungermann, Christian   +5 more
core   +1 more source

Protein Palmitoylation Regulates Cell Survival by Modulating XBP1 Activity in Glioblastoma Multiforme

Molecular Therapy: Oncolytics, 2020
Glioblastoma multiforme (GBM) almost invariably acquires an invasive phenotype, resulting in limited therapeutic options. Protein palmitoylation markedly affects tumorigenesis and malignant progression in GBM.
Xueran Chen, Hao Li, Xiaoqing Fan, Chenggang Zhao, Kaiqin Ye, Zhiyang Zhao, Lizhu Hu, Huihui Ma, Hongzhi Wang, Zhiyou Fang   +9 more
doaj   +1 more source

Palmitoyltransferase DHHC9 and acyl protein thioesterase APT1 modulate renal fibrosis through regulating β-catenin palmitoylation

Nature Communications, 2023
palmitoylation, a reversible post-translational modification, is initiated by the DHHC family of palmitoyltransferases and reversed by several acyl protein thioesterases.
Mengru Gu, Hanlu Jiang, Mengzhu Tan, Long Yu, Ning Xu, Ying Li, Han Wu, Qing Hou, Chunsun Dai   +8 more
semanticscholar   +1 more source

Acid Sphingomyelinase Regulates the Localization and Trafficking of Palmitoylated Proteins [PDF]

, 2019
In human, loss of Acid Sphingomeylinase (ASM/SMPD1) causes Niemann-Pick Disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. ...
Kim, Yongsoon, Lee, Chia-Fang, Li, Wenjing, Sun, Hong, Xiong, Xiahui, Yu, Jiekai, Zhang, Hul, Zhu, Linyu   +7 more
core   +2 more sources

Protein Palmitoylation Modification During Viral Infection and Detection Methods of Palmitoylated Proteins

Frontiers in Cellular and Infection Microbiology, 2022
Protein palmitoylation—a lipid modification in which one or more cysteine thiols on a substrate protein are modified to form a thioester with a palmitoyl group—is a significant post-translational biological process. This process regulates the trafficking,
Xiaoling Li, Lingyi Shen, Zhao Xu, Wei Liu, Aihua Li, Jun Xu   +5 more
doaj   +1 more source