Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis [PDF]
, 2011 hPAR2 (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors).
Alyn H. Morice +54 more
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, 2011 Biomaterials are often soft materials. There is now growing interest in designing, synthesizing and characterising soft materials that mimic the properties of biological materials such as tissue, proteins, DNA or cells. Research on biomimetic soft matter
Hamley, Ian
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Chimeric glutamate receptor subunits reveal the transmembrane domain is sufficient for NMDA receptor pore properties but some positive allosteric modulators require additional domains [PDF]
, 2016 NMDA receptors are ligand-gated ion channels that underlie transmission at excitatory synapses and play an important role in regulating synaptic strength and stability.
Huettner, Jmaes E +2 more
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Multiple palmitoyl acyltransferases modify DAT palmitoylation (803.5)
The FASEB Journal, 2014 The dopamine transporter (DAT) mediates the reuptake of synaptic dopamine, thus regulating dopaminergic neurotransmission. DAT undergoes palmitoylation in which a saturated 16‐carbon palmitate group is linked to cysteine via a thioester bond. Palmitoylation regulates diverse aspects of neuronal protein trafficking and function, but its role in DAT ...
Danielle E. Rastedt +2 more
openaire +1 more source
Pathophysiological Role of Caveolae in Hypertension [PDF]
, 2019 Caveolae, flask-shaped cholesterol-, and glycosphingolipid-rich membrane microdomains, contain caveolin 1, 2, 3 and several structural proteins, in particular Cavin 1-4, EHD2, pacsin2, and dynamin 2.
Daumke, Oliver +4 more
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Gephyrin palmitoylation and oligomerization in synaptic plasticity, membrane recruitment and proteostasis [PDF]
, 2012 Efficient signal transmission in the central nervous system is essential for higher brain functions. Inhibitory signaling in the brain primarily takes place at GABAergic (γ-aminobutyric acid) synapses and balances the activity of excitatory synapses ...
Dejanovic, Borislav
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Semliki Forest viiruse replikaasivalgu nsP1 uurimine [PDF]
, 2013 Väitekirja elektrooniline versioon ei sisalda publikatsioone.Semliki Forest viirus kuulub alfaviiruste perekonda sugukonnas Togaviridae. Alfaviirused on olulised patogeenid ning põhjustavad erinevaid vaevusi nii loomadele kui ka inimestele.
Karo-Astover, Liis
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Development of chemical tools to study protein palmitoylation and palmitoyl acyltransferases
, 2015 Protein palmitoylation is an attachment of palmitate which is one of the most common post-translational modifications (PTMs) of proteins. It is important in various cellular events, and dysregulation has been observed in many diseases including cancer and neurological/neuropsychiatric disorders.
openaire +4 more sources
The 5-hydroxytryptamine(4a) receptor is palmitoylated at two different sites and acylation is critically involved in regulation of receptor constitutive activity [PDF]
, 2002 Bickmeyer, Ulf +6 more
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