Results 111 to 120 of about 1,588 (158)

Ultramicronized palmitoylethanolamide reduces viscerovisceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis: role of mast cells.

, 2016
The effects of ultramicronized palmitoylethanolamide were evaluated on pain behaviours and markers of mast cell (MC) activity in 'a rat model of endometriosis plus ureteral calculosis (ENDO+STONE)-induced viscerovisceral hyperalgesia (VVH).
De Filippis, D, IALENTI, ARMANDO, Vaia, M, IUVONE, TERESA, Negro, L, Costantini, R, Affaitati, G, Lopopolo, M, Grassia, G, Lapenna, D, Cipollone, F, Giamberardino, Ma   +11 more
core   +1 more source

Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold?

Drug Design, Development and Therapy, 2016
Jan M Keppel Hesselink,1 Flavia Chiosi,2 Ciro Costagliola2 1University of Witten/Herdecke, Witten, Germany; 2Eye Clinic, Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy Abstract: Resolvins are a novel class of lipid ...
Hesselink JMK, Chiosi F, Costagliola C
doaj  

Micronized Palmitoylethanolamide: A Post Hoc Analysis of a Controlled Study in Patients with Low Back Pain - Sciatica

, 2019
BACKGROUND: Despite being widely prescribed, relatively few controlled trials have been conducted on the class of neurotrophic/antinociceptive nutraceuticals.
Stefano, Giulia Di, Marchettini, Paolo, Truini, Andrea, Cruccu, Giorgio   +3 more
core   +1 more source

Fixed combination of palmitoylethanolamide and melatonin in preventive therapy of migraine: results from a randomized clinical trial

Frontiers in Nutrition
IntroductionMigraines are neurological disorders which significantly impact quality of life. Current pharmacological treatments often have adverse effects, prompting the search for alternatives with fewer side effects.
Vincenzo Piccolo, Adua Marzocchi, Maria Maisto, Vincenzo Summa, Gian Carlo Tenore, Angela Amoresano, Angela Amoresano   +6 more
doaj   +1 more source

Palmitoylethanolamide for Nickel Allergy: Plausible, Untested, and Worth Considering

Biomedicines
Nickel allergy remains the most prevalent cause of allergic contact dermatitis worldwide, imposing a substantial socio-epidemiological and economic burden. Beyond its classical cutaneous presentation, systemic nickel allergy syndrome highlights the systemic dimension of Nickel hypersensitivity, wherein dietary nickel intake may provoke both ...
Irene Palenca, Silvia Basili Franzin, Giovanni Sarnelli, Giuseppe Esposito   +3 more
openaire   +2 more sources

Effect of Palmitoylethanolamide Compared to a Placebo on the Gut Microbiome and Biochemistry in an Overweight Adult Population: A Randomised, Placebo Controlled, Double-Blind Study

Biomedicines
This study investigates the effects of palmitoylethanolamide (PEA) on the gut microbiome of overweight adults. Fifty-eight participants (twenty males, thirty-eight females) aged 18–65 years with a BMI range of 30–40 kg/m2 were recruited.
Romeo Batacan, David Briskey, Yadav Sharma Bajagai, Chelsie Smith, Dana Stanley, Amanda Rao   +5 more
doaj   +1 more source

Lactiplantibacillus sp. LP03 alleviates pulmonary fibrosis by modulating gut microbiota and elevating host palmitoylethanolamide to suppress TGF-β1/Smad2/3-mediated EMT

Frontiers in Microbiology
IntroductionIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with limited treatment options. Emerging evidence suggests that gut microbiota dysbiosis contributes to pulmonary disorders, underscoring the therapeutic
Yuhao Zhou, Yuhao Zhou, Meina Duan, Meina Duan, Xiaoye Fan, Xiaoye Fan, Yuzhe Zhao, Yuzhe Zhao, Chao Wang, Tingting Wang, Shucheng Hua, Shucheng Hua   +11 more
doaj   +1 more source

Palmitoylethanolamide as a novel green gelator in oleogels

Journal of Dispersion Science and Technology
Palmitoylethanolamide (PMEA), an endogenous lipid with therapeutic properties, was investigated as a green gelator for cosmetic oleogels. It formed stable gels in olive oil (OO), caprylic capric triglyceride (MCT), octyldodecanol (OD), dicaprylyl carbonate (DC), liquid paraffin (LP) and squalane (SQ) with critical gelation concentrations ranging from 1.
Chen, Zhimin, Wang, Jing, Li, Jinhua, Chang, Kuan   +3 more
openaire   +1 more source

Anti-inflammatory Formulations And Uses Thereof Including A Combination Of Palmitoylethanolamide And Plant-based Polyphenols

, 2019
Pharmaceutical or nutraceutical formulations are provided for treating inflammation in a subject in need thereof, as well as methods of treating inflammation in a subject in need thereof by administering one of the formulations.
Mertens-Talcott, Susanne U., Thomas, Ariela Betsy, Pfeifer, Geoffrey R., Venancio, Vinicius De Paula, Ebersole, Blake M.   +4 more
core  

Using palmitoylethanolamide in combination with opioids

, 2014
Described herein are pharmaceutical compositions for human or animal use containing N-palmitoylethanolamide as an analgesic in combination with opioids. In particular, the compositions include palmitoylethanolamide in non-micronized form, in micronized form (PEA-m), in ultra-micronized form (PEAum) or mixtures thereof, for use in humans or animals in ...
DI CESARE MANNELLI, LORENZO, GHELARDINI, CARLA   +1 more
openaire   +1 more source