Results 131 to 140 of about 1,588 (158)

Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice [PDF]

British Journal of Pharmacology, 2001
We have studied the effect of palmitoylethanolamide (PEA, 2.5 – 30 mg kg−1, i.p.) on upper gastrointestinal transit in control mice and in mice with chronic intestinal inflammation induced by croton oil. PEA significantly and dose‐dependently decreased intestinal transit.
Raffaele Capasso, Angelo A Izzo, F Fezza   +2 more
exaly   +5 more sources

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Is there a role for palmitoylethanolamide in the treatment of depression?

Medical Hypotheses, 2014
Depression is a common brain disorder affecting about 350 million people worldwide. Although the pharmacological treatment currently available can produce benefits in the majority of cases, residual depressive symptoms, cognitive deficits, functional impairment, and increase in frequency of relapses are frequently present in unipolar and bipolar ...
M, Coppola, R, Mondola
openaire   +2 more sources

Protective Effect of Palmitoylethanolamide in a Rat Model of Cystitis

Journal of Urology, 2015
PEA is an endogenous mediator released together with the endocannabinoid anandamide from membrane phospholipids. It is a plant derived compound with analgesic and anti-inflammatory properties. We verified whether the pathophysiology of experimental cystitis involves changes in the levels of PEA and of some of its targets, ie CB1 and CB2 receptors, and ...
Pessina, F, CAPASSO, RAFFAELE, BORRELLI, FRANCESCA, Aveta, T, Buono, L, Valacchi, G, Fiorenzani, P, Di Marzo, V, Orlando, P, IZZO, ANGELO ANTONIO   +9 more
openaire   +3 more sources

Effect of Diet on Tissue Levels of Palmitoylethanolamide

CNS & Neurological Disorders - Drug Targets, 2013
Palmitoylethanolamide (PEA) as well as the other N-acylethanolamines (NAEs), e.g. anandamide, oleoylethanolamide, stearoylethanolamide and linoleoylethanolamide, appear to exist in every mammalian cell at low levels, e.g. a few hundred pmol/g tissue for PEA. Their formation can be stimulated by cellular injury and inflammation.
openaire   +2 more sources

Anti‐inflammatory Effect of Palmitoylethanolamide on Human Adipocytes

Obesity, 2009
Obesity leads to the appearance of an inflammatory process, which can be initiated even with a moderate weight gain. Palmitoylethanolamide (PEA) is an endogenous lipid, secreted by human adipocytes, that possesses numerous anti‐inflammatory properties.
Hoareau L, Buyse M, Festy F, Ravanan P, Gonthier MP, Matias I, Petrosino S, Tallet F, d'Hellencourt CL, Cesari M, Di Marzo V, Roche R   +11 more
openaire   +4 more sources

Palmitoylethanolamide as adjunctive therapy in major depressive disorder: A double-blind, randomized and placebo-controlled trial

Journal of Affective Disorders, 2018
Background: Experimental studies provide evidence for antidepressant effects of Palmitoylethanolamide (PEA) in animal models of depression. We aimed to evaluate the efficacy and tolerability of PEA add-on therapy in treatment of patients with major ...
Alireza Ghajar, Mohammadreza Shalbafan, Mohsen Afarideh   +2 more
exaly   +1 more source

Ultra-micronized palmitoylethanolamide ...

2018
Chronic pain is associated with cognitive deficits. Palmitoylethanolamide (PEA) has been shown to ameliorate pain and pain-related cognitive impairments by restoring glutamatergic synapses functioning in the spared nerve injury (SNI) of the sciatic nerve in mice.
Boccella S(1), Cristiano C(2), Romano R(1), Iannotta M(1), Belardo C(1), Farina A(1), Guida F(1), Piscitelli F(3), Palazzo E(1), Mazzitelli M(4), Imperatore R(5), Tunisi L(3), de Novellis V(1), Cristino L(3), Di Marzo V(3), Calignano A(2), Maione S(1), Luongo L(6).   +17 more
openaire   +1 more source

New Insights in Mast Cell Modulation by Palmitoylethanolamide

CNS & Neurological Disorders - Drug Targets, 2013
Since its discovery palmitoylethanolamide was considered as an endogenous compound able to negatively modulate the inflammatory process. Its effects have been extensively investigated in in vitro, in vivo and in clinical studies. Notwithstanding some discrepancy, nowadays the efficacy of palmitoylethanolamide in controlling mast cell behaviour, which ...
DE FILIPPIS, DANIELE, NEGRO, LUANA, Vaia M, Cinelli MP, IUVONE, TERESA   +4 more
openaire   +3 more sources

Palmitoylethanolamide: One molecule, different formulations

Psychiatry and Clinical Neurosciences, 2023
openaire   +2 more sources

Occipital Neuralgia Responding to Palmitoylethanolamide

Headache: The Journal of Head and Face Pain, 2013
R. S. Calabrò, BRAMANTI, Placido
openaire   +2 more sources