Results 121 to 130 of about 1,588 (158)

Palmitoylethanolamide as an emerging therapy for neurodegenerative diseases

Rehabilitation and Sports Medicine
Palmitoylethanolamide (PEA) was studied for its neuroprotective, anti-inflammatory and analgesic properties. Recent research has shown that it protects HT-22 neuronal cells from oxidative stress caused by hypoxia and reoxygenation, through the activation of signalling pathways such as pAkt and ERK1/2.
Isabela Petrone Arifa, Lucas Daniel Udovin   +1 more
openaire   +1 more source

Pharmacology of Palmitoylethanolamide and Related Compounds

, 2005
Anandamide (AEA) is an endogenous fatty acid which activates the same cannabinoid receptors as ∆9-tetrahydrocannabinol, the psychoactive substance in marijuana. In vivo, anandamide exerts a number of actions including effects upon pain and inflammation.
openaire   +1 more source

Therapeutic benefit of palmitoylethanolamide in the management of neuropathic pain

, 2018
Background: Neuropathic pain is defined by International Association for the Study of Pain (IASP) as “Pain caused by a lesion or disease of the somatosensory nervous system”. Elderly patients generally have high incidence of chronic neuropathic pain. The
Malpani, Prateek, Tiwari, Shashikant, Chaurasia, I. D., Koshariya, Mahim, Behram, Sheikh, Vinayak, Kunal   +5 more
core  

Corrigendum: Oral ultramicronized palmitoylethanolamide: plasma and tissue levels and spinal antihyperalgesic effect

Frontiers in Pharmacology
Stefania Petrosino, Stefania Petrosino, Marika Cordaro, Roberta Verde, Aniello Schiano Moriello, Aniello Schiano Moriello, Gabriele Marcolongo, Carlo Schievano, Rosalba Siracusa, Fabiana Piscitelli, Alessio F. Peritore, Rosalia Crupi, Daniela Impellizzeri, Emanuela Esposito, Salvatore Cuzzocrea, Vincenzo Di Marzo   +15 more
doaj   +1 more source

The search for the palmitoylethanolamide receptor [PDF]

Life Sciences, 2005
Palmitoylethanolamide (PEA), the naturally occurring amide of ethanolamine and palmitic acid, is an endogenous lipid that modulates pain and inflammation. Although the anti-inflammatory effects of PEA were first characterized nearly 50 years ago, the identity of the receptor mediating these actions has long remained elusive.
Jesse Loverme, Giovanna La Rana, Roberto Russo   +2 more
exaly   +8 more sources

Nanoparticles prolong N-palmitoylethanolamide anti-inflammatory and analgesic effects in vivo

Colloids and Surfaces B: Biointerfaces, 2016
N-Palmitoylethanolamide showed great therapeutic potential in the treatment of inflammation and pain but its unfavourable pharmacokinetics properties will hinder its use in the clinical practice.
Alessia Offerta, Carmine Ostacolo, Roberto Russo   +2 more
exaly   +3 more sources

Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide

British Journal of Pharmacology, 2001
1 The ability of a series of homologues and analogues of palmitoylethanolamide to inhibit the uptake and fatty acid amidohydrolase (FAAH)-catalysed hydrolysis of [H-3]-anandamide ([H-3]-AEA) has been investigated.
Kent-Olov Jonsson, Severine Vandevoorde, Didier M Lambert   +2 more
exaly   +2 more sources

Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB2 cannabinoid, as potential ligands for the cannabinoid receptors

Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 1999
peer reviewedThe presence of CB(2) receptors was reported in the rat basophilic cell line RBL-2H3 and N-palmitoylethanolamide was proposed as an endogenous, potent agonist of this receptor. We synthesized a series of 10 N-palmitoylethanolamide homologues
Didier M Lambert, Pierre Sonveaux, Emmanuel Hermans   +2 more
exaly   +2 more sources

Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy [PDF]

British Journal of Clinical Pharmacology, 2016
Palmitoylethanolamide (PEA) has been suggested to have useful analgesic properties and to be devoid of unwanted effects. Here, we have examined critically this contention, and discussed available data concerning the pharmacokinetics of PEA and its formulation.
Sofia Mattsson, Christopher J Fowler
exaly   +4 more sources

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Non-specific resistance induced by palmitoylethanolamide

Toxicon, 1972
Abstract The effectiveness of a naturally occurring lipid, palmitoylethanolamide (PEA) in enhancement of non-specific resistance was investigated in mice. The optimal oral dosage was 50 mg/kg, administered for 12 consecutive days. PEA treatment decreased markedly the mortality of animals injected either with Shigella dysenteriae toxin, Streptolysin O
H, Rasková, K, Masek, O, Linèt
openaire   +3 more sources