Results in Surfaces and InterfacesThe clinical efficacy of topotecan (TPT) is limited by its instability and rapid clearance, motivating the search for nanoscale carriers capable of enhancing its delivery.
Mehdi Yoosefian +3 more
doaj +1 more source
Engineered Optical Fibers for Deep‐Tissue Applications
Advanced Optical Materials, Volume 14, Issue 10, 13 March 2026.This review establishes a foundational framework for designing optical fibers for deep‐tissue medicine. It systematically links material innovations like polymers and hydrogels with structural paradigms to enable state‐of‐the‐art diagnostics, including endoscopy and biosensing, and targeted therapeutics, guiding future clinical translation.
Yuzhen Li +16 more
wiley +1 more source
PAMAM Dendrimers as Promising Nanocarriers for RNAi Therapeutics [PDF]
, 2015 Therapeutics based on RNA interference mechanisms are highly promising for the management of several diseases including multi-drug resistant cancers. However, effective delivery of siRNAs and oligonucleotides still remains challenging.
Amin, Mohd Cairul Iqbal Mohd +6 more
core +2 more sources
Low-generation asymmetric dendrimers exhibit minimal toxicity and effectively complex DNA [PDF]
, 2011 Conventional dendrimers are spherical symmetrically branched polymers ending with active surface functional groups. Polyamidoamine (PAMAM) dendrimers have been widely studied as gene delivery vectors and have proven effective at delivering DNA to cells ...
Parekh, Harendra S. +2 more
core +1 more source
In vitro antibacterial activity of poly (amidoamine)-G7 dendrimer
BMC Infectious Diseases, 2017 Background Nano-scale dendrimers are synthetic macromolecules that frequently used in medical and health field. Traditional anibiotics are induce bacterial resistence so there is an urgent need for novel antibacterial drug invention. In the present study
Mitra Gholami +7 more
doaj +1 more source
In vivo study of dendron-like nanoparticles for stem cells tune-up : from nano to tissues [PDF]
, 2011 The control of stem cell differentiation to obtain osteoblasts in vivo is still regarded as a challenge in stem-cell-based and bone-tissue engineering strategies.
Hirose, Motohiro +8 more
core +1 more source
Molecular interactions between dimethoxycurcumin and Pamam dendrimer carriers
International Journal of Pharmaceutics, 2007 Dimethoxycurcumin, a lipophilic analog of curcumin found as a major pigment in the Indian species turmeric (Curcuma longa Linn.), is known to possess significant activity against various cancer cell lines, but its use as an anticancer drug is hindered by its poor water solubility.
Markatou, E. +5 more
openaire +4 more sources
Carboxymethylchitosan/poly (amidoamine) dendrimer nanoparticles in central nervous systems-regenerative medicine: effects on neuron/glial cell viability and internalization efficiency [PDF]
, 2010 The applicability of CMCht/PAMAM dendrimer nanoparticles for CNS applications was investigated. AFM and TEM observations revealed that the nanoparticles possessed a nanosphere- like shape with a size from 22.0 to 30.7 nm.
Alyautdin +33 more
core +1 more source
Elasticity of DNA and the effect of Dendrimer Binding
, 2013 Negatively charged DNA can be compacted by positively charged dendrimers and the degree of compaction is a delicate balance between the strength of the electrostatic interaction and the elasticity of DNA.
Maiti, Prabal K. +3 more
core +1 more source
Biophysical studies in polymer therapeutics: the interactions of anionic and cationic PAMAM dendrimers with lipid monolayers [PDF]
, 2017 Understanding how polymers interact with biological membranes is important for the development of polymer based therapeutics and wider biomedical applications.
Aronson PS +6 more
core +1 more source