Results 91 to 100 of about 41,761 (267)

Epidermal Growth Factor–PEG Functionalized PAMAM-Pentaethylenehexamine Dendron for Targeted Gene Delivery Produced by Click Chemistry [PDF]

, 2011
Aim of this study was the site-specific conjugation of an epidermal growth factor (EGF)-polyethylene glycol (PEG) chain by click chemistry onto a poly(amido amine) (PAMAM) dendron, as a key step toward defined multifunctional carriers for targeted gene ...
Balogh L., Bartlett D. W., Blessing T., Boeckle S., Boussif O., Carboni B., Carlin C. R., Choi J. S., Christian Dohmen, Davis M. E., Davis M. E., de Bruin K., Ernst Wagner, Esfand R., Haijun Yu, Hua C., Iyer J., Kannan R. M., Kataoka K., Kircheis R., Kircheis R., Kloeckner J., Kloeckner J., Kursa M., Lee J. W., Li S. D., Luo D., Lutz J. F., Maeda H., Maiti P. K., Meyer M., Navarro G., Nie Y., Ogris M., Plank C., Plank C., Russ V., Russ V., Russ V., Schaffert D., Shir A., Simoes S., Svenson S., Tomalia D. A., Tomalia D. A., von Gersdorff K., Wagner E., Wagner E., Walker G. F., Wolschek M. F., Wood K. C., Yellepeddi V. K., Yu H., Yu H., Yu Nie, Yunqiu Li, Zhang X. Q., Zhao X., Zou S. M., Zugates G. T.   +59 more
core   +1 more source

Preferential and Increased Uptake of Hydroxyl-Terminated PAMAM Dendrimers by Activated Microglia in Rabbit Brain Mixed Glial Culture

Molecules, 2018
Polyamidoamine (PAMAM) dendrimers are multifunctional nanoparticles with tunable physicochemical features, making them promising candidates for targeted drug delivery in the central nervous system (CNS).
Yossef Alnasser, Siva P. Kambhampati, Elizabeth Nance, Labchan Rajbhandari, Shiva Shrestha, Arun Venkatesan, Rangaramanujam M. Kannan, Sujatha Kannan   +7 more
doaj   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Dendrimer-coated carbon nanotubes deliver dsRNA and increase the efficacy of gene knockdown in the red flour beetle Tribolium castaneum

Scientific Reports, 2020
In this study, the use of dendrimer-coated carbon nanotubes (CNTs) as a delivery vehicle for dsRNA was assessed in Tribolium castaneum. Exposure to low dosages of polyamidoamine dendrimer carbon nanotubes (PAMAM-CNTs) did not affect T.
Catriona H. Edwards, Craig R. Christie, Andrea Masotti, Antonella Celluzzi, Andrea Caporali, Ewan M. Campbell   +5 more
doaj   +1 more source

Deciphering the Chemotherapeutic Mechanism of Ferulic Acid: Insight Into the Role Against Multiple Human Cancers

Cancer Innovation, Volume 5, Issue 2, April 2026.
Ferulic acid (FA), a naturally occurring compound, exhibits anticancer activity against 16 cancer types through multiple molecular pathways. Its enhanced delivery via nanoformulations and synergistic effects with other therapies suggest FA as a promising, food‐based adjunct for cancer symptom control until fully approved pharmaceutical options are ...
Sanzida Khatun, Md Sohel, Zitu Barman, Umme Salma, Lubatul Arbia, Md. Rifat Sarker, Jasmin Akter Jame, Badhan Rani Dey, Sultana Parvin, Md. Shah Poran Shuvo, Md. Shahidul Islam, Tania Mannan, Snygdha Rani Das, Md. Mahmudul Hasan   +13 more
wiley   +1 more source

Potential Use of Folate-polyethylene glycol (PEG)-Appended Dendrimer (G3) Conjugate with alpha-Cyclodextrin as DNA Carriers to Tumor Cells [PDF]

, 2011
We previously reported that polyamidoamine STARBURST dendrimer (generation 3, G3) (dendrimer) conjugate with alpha-cyclodextrin (alpha-CyD) having an average degree of substitution of 2.4 of alpha-CyD (alpha-CDE) provided remarkable aspects as novel ...
Ayumi Yoshimitsu, Fumitoshi Hirayama, Haruna Ikeda, Hidetoshi Arima, Kaneto Uekama, Keiichi Motoyama, Kenjiro Hattori, Masayo Arizono, Taishi Higashi, Tomoko Takeuchi   +9 more
core   +1 more source

Charged dendrimers revisited: Effective charge and surface potential of dendritic polyglycerol sulfate

, 2017
We investigate key electrostatic features of charged dendrimers at hand of the biomedically important dendritic polyglycerol sulfate (dPGS) macromolecule using multi-scale computer simulations and Zetasizer experiments.
Ballauff, Matthias, Dzubiella, Joachim, Haag, Rainer, Ran, Qidi, Xu, Xiao   +4 more
core   +1 more source

Surface engineered carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles for intracellular targeting [PDF]

, 2008
Novel highly branched biodegradable macromolecular systems have been developed by grafting carboxymethylchitosan (CMCht) onto low generation poly(amidoamine) (PAMAM) dendrimers.
Benesch, Johan, Costa, Silgia, Hajime, Ohgushi, Hirose, Motohiro, Kotobuki, Noriko, Mano, J. F., Marques, A. P., Oliveira, Joaquim M., Pirraco, Rogério, Reis, R. L.   +9 more
core   +1 more source

PAMAM dendrimers based co-delivery of methotrexate and berberine for targeting of Hela cancer cells

Toxicology Reports
Polyamidoamine dendrimer (PAMAM) is a class of synthetic macromolecular polymers for targeted drug delivery. PAMAM dendrimers are characterized by a pure defined structure, adjustable nanoscale dimensions, mono-dispersity, and versatile surface ...
Hossein Majidzadeh, Mostafa Araj-Khodaei, Ayuob Aghanejad, Maryam Ghaffari, Amir Jafari, Forough Jenanifard, Jafar Ezzati Nazhad Dolatabadi, Hashem Andishmand, Michael R. Hamblin   +8 more
doaj   +1 more source

Effect of methotrexate conjugated PAMAM dendrimers on the viability of MES-SA uterine cancer cells

Journal of Pharmacy and Bioallied Sciences, 2014
The aim of this work was to synthesize methotrexate (MTX)-polyamidoamine (PAMAM) dendritic nanoconjugates and to study their effect on cell viability in uterine sarcoma cells.
Samreen Khatri, Nandita G Das, Sudip K Das   +2 more
doaj   +1 more source