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Performance evaluation of PAMAM dendrimer based simvastatin formulations
International Journal of Pharmaceutics, 2011The purpose of this investigation was to evaluate the performance of poly (amidoamine) (PAMAM) dendrimers, with three different surface groups, to be used as drug carriers. Drug-dendrimers complexes were investigated for solubility studies, dissolution studies, in vitro drug release studies, and for stability studies.
Hitesh, Kulhari +3 more
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Thermodynamic Analysis of PAMAM Dendrimer Synthesis
2023The objective of this research was to determine kinetic and thermodynamic data about the reaction between ethylene diamine and methyl acrylate which is used in the production of PAMAM dendrimers. Establishing a rate law and finding values such as rate constant, activation energy, and Arrhenius coefficient will help in determining the best possible ...
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Interactions between PAMAM dendrimers and bovine serum albumin
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003Dendrimers are a new class of polymeric materials. They are globular, highly branched, monodisperse macromolecules. Due to their structure, dendrimers promise to be new, effective biomedical materials as oligonucleotide transfection agents and drug carriers. More information about biological properties of dendrimers is crucial for further investigation
Barbara, Klajnert +3 more
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Molecular simulation study of PAMAM dendrimer composite membranes
Journal of Molecular Modeling, 2014Pure polysulfone (PSF) and its composites with chitosan (CST), hyaluronic acid (HA), conventional poly(amidoamine), and hydroxyl poly(amidoamine) dendrimers as the membranes for separation of the gases, methane, carbon dioxide, hydrogen sulfide, nitrogen, and oxygen have been studied by molecular dynamics (MD) and grand canonical Monte Carlo (GCMC ...
Sepideh, Amjad-Iranagh +2 more
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Surface modification of PAMAM dendrimer improves its biocompatibility
Nanomedicine: Nanotechnology, Biology and Medicine, 2012Modification of dendrimer surface groups is one of the methods available to obtain compounds characterized by reduced toxicity. This article reports results of preliminary biocompatibility studies of a modified polyamidoamine dendrimer of the fourth generation.
Ciolkowski, Michal +6 more
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Preliminary biological evaluation of polyamidoamine (PAMAM) StarburstTM dendrimers
Journal of Biomedical Materials Research, 1996PAMAM Starburst dendrimers are spherical macromolecules composed of repeating polyamidoamino units. They can be produced in successive "generations," each with a defined size, molecular weight, and number of terminal amino groups. Because of these well-defined characteristics, PAMAMs are finding utility in a variety of applications, many of which are ...
J C, Roberts, M K, Bhalgat, R T, Zera
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PAMAM Dendrimer-Induced Aggregation of 5(6)-Carboxyfluorescein
The Journal of Organic Chemistry, 2012The binding of the fluorescent polyanionic probe 5(6)-carboxyfluorescein (CF) to various generations of dendrimers (G3-G7) was studied in buffered aqueous media by absorbance and fluorescence spectroscopy and by isothermal titration calorimetry (ITC).
Marco, Bonizzoni +3 more
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Association of small aromatic molecules with PAMAM dendrimers
Physical Chemistry Chemical Physics, 2015Dendrimer pockets enable association by reducing naphthalene hydration even near the dendrimer periphery.
Ryan S, DeFever, Sapna, Sarupria
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PAMAM Dendrimer Based Macromolecules as Improved Contrast Agents
Molecular Pharmaceutics, 2005Dendrimers are an attractive platform for macromolecular imaging due to the presence of multiple terminal groups on the exterior of the molecule. Through application of appropriate metal ion chelates, large numbers of metal ions for imaging (paramagnetic or radioopaque) and therapy (radioactive particle emitters) may be conjugated to the dendrimer in ...
Vincent J, Venditto +2 more
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