Results 31 to 40 of about 13,061 (210)
Epidermal Growth Factor–PEG Functionalized PAMAM-Pentaethylenehexamine Dendron for Targeted Gene Delivery Produced by Click Chemistry [PDF]
, 2011 Aim of this study was the site-specific conjugation of an epidermal growth factor (EGF)-polyethylene glycol (PEG) chain by click chemistry onto a poly(amido amine) (PAMAM) dendron, as a key step toward defined multifunctional carriers for targeted gene ...
Balogh L. +59 more
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Acetylation of PAMAM dendrimers for cellular delivery of siRNA
BMC Biotechnology, 2009 Background The advancement of gene silencing via RNA interference is limited by the lack of effective short interfering RNA (siRNA) delivery vectors. Rational design of polymeric carriers has been complicated by the fact that most chemical modifications ...
Uhrich Kathryn E +3 more
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Nanomaterials, 2021 Gene therapy is used to correct or compensate for diseases caused by gene defects and abnormalities. Improving the transfection efficiency and reducing the toxicity of gene carriers are the keys to gene therapy. Similar to a typical cationic gene carrier—
Yanzhen Sun +3 more
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Cationic PAMAM Dendrimers Disrupt Key Platelet Functions [PDF]
Molecular Pharmaceutics, 2012 Poly(amidoamine) (PAMAM) dendrimers have been proposed for a variety of biomedical applications and are increasingly studied as model nanomaterials for such use. The dendritic structure features both modular synthetic control of molecular size and shape and presentation of multiple equivalent terminal groups.
Clinton F, Jones +12 more
openaire +2 more sources
Which Dendrimer to Attain the Desired Properties? Focus on Phosphorhydrazone Dendrimers
Molecules, 2018 Among the six Critical Nanoscale Design Parameters (CNDPs) proposed by Prof. Donald A. Tomalia, this review illustrates the influence of the sixth one, which concerns the elemental composition, on the properties of dendrimers.
Anne-Marie Caminade, Jean-Pierre Majoral
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Condensation transition in DNA-polyaminoamide dendrimer fibers studied using optical tweezers [PDF]
, 2006 When mixed together, DNA and polyaminoamide (PAMAM) dendrimers form fibers that condense into a compact structure. We use optical tweezers to pull condensed fibers and investigate the decondensation transition by measuring force-extension curves (FECs ...
C. Bustamante +6 more
core +2 more sources
Generation 3 PAMAM dendrimer TAMRA conjugates containing precise dye/dendrimer ratios [PDF]
Materials Today Communications, 2015 The synthesis, isolation, and characterization of generation 3 poly(amidoamine) (G3 PAMAM) dendrimer containing precise ratios of 5-carboxytetramethylrhodamine succinimidyl ester (TAMRA) dye (n = 1-3) per polymer particle are reported. Stochastic conjugation of TAMRA dye to the dendrimer was followed by separation into precise dye-polymer ratios using ...
Janet, Manono +5 more
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Molecules, 2018 The polyamidoamine (PAMAM) dendrimer is a highly efficient absorption promoter. In the present study, we studied the absorption-enhancing effects and the mechanism of PAMAM dendrimers with generation 0 to generation 3 (G0–G3) and concentrations (0 ...
Juan Lu +9 more
doaj +1 more source
Molecules, 2013 Erythromycin (EM) and tobramycin (TOB) are well-known and widely used antibiotics, belonging to different therapeutic groups: macrolide and aminoglycoside, respectively.
Elzbieta Anna Tryniszewska +4 more
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Molecules, 2018 Dendrimers have come a long way in the last 25 years since their inception. Originally created as a wonder molecule of chemistry, dendrimer is now in the fourth class of polymers. Dr.
Abhay Singh Chauhan
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