Results 71 to 80 of about 13,061 (210)
Successful Application of the Mast Cell Activation Test in Immediate Hypersensitivity to Amoxicillin
Allergy, EarlyView.This study included 28 amoxicillin‐allergic patients and 11 healthy exposed controls. Mast cells were differentiated from CD34+ progenitors over 8 weeks using cytokine cocktails. The mast cell activation test involved sensitization with patient or control sera and stimulation with free amoxicillin or G4/G5‐AXO dendrimers with successfully activated ...
Jose A. Céspedes +11 more
wiley +1 more source
Comparison of MRI properties between multimeric DOTAGA and DO3A gadolinium-dendron conjugates [PDF]
, 2019 The inherent lack of sensitivity of MRI needs the development of new Gd contrast agents in order to extend 20Hz,37%, the application of this technique to cellular imaging.
Boutry, Sébastien +13 more
core +3 more sources
PAMAM dendrimer: a pH-controlled nanosponge [PDF]
Canadian Journal of Chemistry, 2017 Using fully atomistic molecular dynamics simulation that are several hundred nanoseconds long, we demonstrate the pH-controlled sponge action of PAMAM dendrimer. We show how at varying pH levels, the PAMAM dendrimer acts as a wet sponge; at neutral or low pH levels, the dendrimer expands noticeably and the interior of the dendrimer opens up to host ...
openaire +1 more source
The FEBS Journal, EarlyView.The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs +7 more
wiley +1 more source
, 2017 We investigate key electrostatic features of charged dendrimers at hand of the biomedically important dendritic polyglycerol sulfate (dPGS) macromolecule using multi-scale computer simulations and Zetasizer experiments.
Ballauff, Matthias +4 more
core +1 more source
PPH dendrimers grafted on silica nanoparticles: surface chemistry, characterization, silver colloids hosting and antibacterial activity [PDF]
, 2013 Polyphosphorhydrazone (PPH) dendrimers have been grafted on silica nanoparticles, and the surface functions of the dendrimers have been derivatized to phosphonates with lateral poly(ethyleneglycol) (PEG) chains.
Caminade, Anne-Marie +6 more
core +4 more sources
Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease
Advanced Materials, Volume 38, Issue 17, 20 March 2026.RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley +1 more source
Molecular modelling of dendrimers for nanoscale applications [PDF]
, 2000 Dendrimers are well defined, highly branched macromolecules that radiate from a central core and are synthesized through a stepwise, repetitive reaction sequence that guarantees complete shells for each generation, leading to polymers that are ...
Breen, Nicholas +4 more
core
Structure of Carbon Nanotube-dendrimer composite
, 2012 Using all atomistic molecular dynamics (MD) simulations we report the microscopic picture of the nanotube-dendrimer complex for PAMAM dendrimer of generation 2 to 4 and carbon nanotube of chirality (6,5).
Maiti, Prabal K +3 more
core +1 more source
PAMAM Dendrimers as Promising Nanocarriers for RNAi Therapeutics [PDF]
, 2015 Therapeutics based on RNA interference mechanisms are highly promising for the management of several diseases including multi-drug resistant cancers. However, effective delivery of siRNAs and oligonucleotides still remains challenging.
Amin, Mohd Cairul Iqbal Mohd +6 more
core +2 more sources