Results 81 to 90 of about 13,061 (210)

Engineered Optical Fibers for Deep‐Tissue Applications

Advanced Optical Materials, Volume 14, Issue 10, 13 March 2026.
This review establishes a foundational framework for designing optical fibers for deep‐tissue medicine. It systematically links material innovations like polymers and hydrogels with structural paradigms to enable state‐of‐the‐art diagnostics, including endoscopy and biosensing, and targeted therapeutics, guiding future clinical translation.
Yuzhen Li, Siyang Zheng, Wenzhao Li, Kai Chen, Tianting Zhong, Chi Man Woo, Weiran Pang, Chuqi Yuan, Xiaozhou Xiao, Xianguang Yang, Long Jin, Xiang Qian, Qiyao Tan, Changyuan Yu, Liwei Liu, Junle Qu, Puxiang Lai   +16 more
wiley   +1 more source

Use of Polyamidoamine Dendrimers in Brain Diseases

Molecules, 2018
Polyamidoamine (PAMAM) dendrimers are one of the smallest and most precise nanomolecules available today, which have promising applications for the treatment of brain diseases. Each aspect of the dendrimer (core, size or generation, size of cavities, and
Maria Florendo, Alexander Figacz, Bhairavi Srinageshwar, Ajit Sharma, Douglas Swanson, Gary L. Dunbar, Julien Rossignol   +6 more
doaj   +1 more source

Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. [PDF]

PLoS ONE, 2015
Cationic polyamidoamine (PAMAM) dendrimers are branch-like spherical polymers being investigated for a variety of applications in nanomedicine including nucleic acid drug delivery.
Saghir Akhtar, Bashayer Al-Zaid, Ahmed Z El-Hashim, Bindu Chandrasekhar, Sreeja Attur, Mariam H M Yousif, Ibrahim F Benter   +6 more
doaj   +1 more source

Original Multivalent Gold (III) and Dual Gold(III)-Copper(II) Conjugated Phosphorus Dendrimers as Potent Antitumoral and Antimicrobial Agents [PDF]

, 2017
Original metallophosphorus dendrimers (generation 3, 48 terminal groups) have been prepared via the complexation of phosphorus dendrimers bearing imino-pyridino end groups with Au(III) or with both Au(III) and Cu(II).
Serge M. Mignani, Nabil El Brahmi, Saïd El Kazzouli, Regis Laurent, Sonia Ladeira, Anne-Marie Caminade, Elzbieta Pedziwiatr-Werbicka, Eligia M. Szewcyk, Maria Bryszewska, Mosto M. Bousmina, Thierry Cresteil, Jean Pierre Majoral   +11 more
core   +2 more sources

Remodeling the Inflammatory Microenvironment: Nanomaterial‐Based Targeted Strategies for Systemic Lupus Erythematosus and Lupus Nephritis

Small Science, Volume 6, Issue 3, March 2026.
Current treatments for severe lupus nephritis are limited by side effects due to poor drug targeting. This review explores how smart nanomaterials—like liposomes and biomimetic carriers—can precisely deliver drugs to overactive immune cells and the kidneys. These nanotherapeutics enhance efficacy, reduce toxicity, and enable combination strategies. The
Cheng Zhou, Jiayi Li, Jian Zhang, Haifeng Wang, Haitao Lu, Shunlai Shang, Wenge Li   +6 more
wiley   +1 more source

Novel Aldehyde-Terminated Dendrimers; Synthesis and Cytotoxicity Assay

BioImpacts, 2012
Introduction: Polyamidoamine (PAMAM) dendrimers are a unique family of dendritic polymers with numerous pharmaceutical and biomedical applications. One major problem with these polymers is their cytotoxicity.
Mohammad-Reza Rashidi, Yadollah Omidi, Saeed Ghasemi, Soodabeh Davaran, Simin Sharifi, Aliasghar Hamidi   +5 more
doaj   +1 more source

Prevention of Synaptic Alterations and Neurotoxic Effects of PAMAM Dendrimers by Surface Functionalization

Nanomaterials, 2017
One of the most studied nanocarriers for drug delivery are polyamidoamine (PAMAM) dendrimers. However, the alterations produced by PAMAM dendrimers in neuronal function have not been thoroughly investigated, and important aspects such as effects on ...
Felipe Vidal, Pilar Vásquez, Francisca R. Cayumán, Carola Díaz, Jorge Fuentealba, Luis G. Aguayo, Gonzalo E. Yévenes, Joel Alderete, Leonardo Guzmán   +8 more
doaj   +1 more source

Potential Use of Folate-polyethylene glycol (PEG)-Appended Dendrimer (G3) Conjugate with alpha-Cyclodextrin as DNA Carriers to Tumor Cells [PDF]

, 2011
We previously reported that polyamidoamine STARBURST dendrimer (generation 3, G3) (dendrimer) conjugate with alpha-cyclodextrin (alpha-CyD) having an average degree of substitution of 2.4 of alpha-CyD (alpha-CDE) provided remarkable aspects as novel ...
Ayumi Yoshimitsu, Fumitoshi Hirayama, Haruna Ikeda, Hidetoshi Arima, Kaneto Uekama, Keiichi Motoyama, Kenjiro Hattori, Masayo Arizono, Taishi Higashi, Tomoko Takeuchi   +9 more
core   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, Volume 13, Issue 10, 18 February 2026.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Predicting cytotoxicity of PAMAM dendrimers using molecular descriptors

Beilstein Journal of Nanotechnology, 2015
The use of data mining techniques in the field of nanomedicine has been very limited. In this paper we demonstrate that data mining techniques can be used for the development of predictive models of the cytotoxicity of poly(amido amine) (PAMAM ...
David E. Jones, Hamidreza Ghandehari, Julio C. Facelli   +2 more
doaj   +1 more source