Type II Cells in the Human Carotid Body Display P2X7 Receptor and Pannexin-1 Immunoreactivity [PDF]
BiomoleculesThe carotid body is a peripheral chemoreceptor that consists of clusters of chemoreceptive type I cells, glia-like type II cells, afferent and efferent nerves, and sinusoidal capillaries and arterioles.
Marcos Anache +10 more
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Serum levels of neurotensin, pannexin-1, and sestrin-2 and the correlations with sleep quality or/and cognitive function in the patients with chronic insomnia disorder [PDF]
Frontiers in PsychiatryObjectivesTo examine serum concentrations of neurotensin, pannexin-1 and sestrin-2, and their correlations with subjective and objective sleep quality and cognitive function in the patients with chronic insomnia disorder (CID).MethodsSixty-five CID ...
Ai-Xi Su +7 more
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Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves [PDF]
Frontiers in Cellular Neuroscience, 2017 The pannexin family of channels consists of three members—pannexin-1 (Panx1), pannexin-2 (Panx2), and pannexin-3 (Panx3) that enable the exchange of metabolites and signaling molecules between intracellular and extracellular compartments.
Steven M. Horton +10 more
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Platelet pannexin-1 channels modulate neutrophil activation and migration but not the progression of abdominal aortic aneurysm [PDF]
Frontiers in Molecular Biosciences, 2023 Abdominal aortic aneurysm (AAA) is a common disease and highly lethal if untreated. The progressive dilatation of the abdominal aorta is accompanied by degradation and remodeling of the vessel wall due to chronic inflammation.
Lisa Maria Metz +11 more
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Powerful partnership: crosstalk between pannexin 1 and the cytoskeleton [PDF]
Frontiers in Physiology, 2014 Pannexin 1 (Panx1) large-pore ion and metabolite channels are emerging as key proteins in many physiological and pathophysiological scenarios. Recent evidence has tightly linked Panx1 trafficking and function to the cytoskeleton, a multi-component ...
Andrew Kenneth Jameson Boyce +5 more
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Inhibition of pannexin‐1 does not restore electrolyte balance in precystic Pkd1 knockout mice [PDF]
Physiological ReportsMutations in PKD1 and PKD2 cause autosomal dominant polycystic kidney disease (ADPKD), which is characterized by the formation of fluid‐filled cysts in the kidney.
Wouter H. vanMegen +5 more
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Pannexin-1 Channels as Mediators of Neuroinflammation [PDF]
International Journal of Molecular Sciences, 2021 Neuroinflammation is a major component of central nervous system (CNS) injuries and neurological diseases, including Alzheimer’s disease, multiple sclerosis, neuropathic pain, and brain trauma. The activation of innate immune cells at the damage site causes the release of pro-inflammatory cytokines and chemokines, which alter the functionality of ...
Seo, Joon Ho +2 more
openaire +4 more sources
Plasma and aqueous humor levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy [PDF]
International Journal of Ophthalmology, 2022 AIM: To evaluate plasma and aqueous levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy. METHODS: The study included three age and gender-matched groups of 20 cataract patients with no diabetes or additional disease ...
Fatih Cem Gül +4 more
doaj +1 more source
Nature Communications, 2022 Pannexin-1 ion channels on endothelial cells regulate vascular inflammation and remodeling to mediate aortic aneurysm formation. Pharmacological blockade of Pannexin-1 channels may offer translational therapeutic mitigation of aneurysmal pathology.
Amanda C. Filiberto +13 more
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Frontiers in Neurology, 2022 AimPrevious studies have proved that inhibiting inflammasome activation provides neuroprotection against early brain injury (EBI) after subarachnoid hemorrhage (SAH), which is mainly focused on the microglial inflammatory response, but the potential role
Yonghe Zheng +6 more
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