Results 21 to 30 of about 5,216 (132)

Knockout of Pannexin-1 Induces Hearing Loss [PDF]

International Journal of Molecular Sciences, 2018
Mutations of gap junction connexin genes induce a high incidence of nonsyndromic hearing loss. Pannexin genes also encode gap junctional proteins in vertebrates. Recent studies demonstrated that Pannexin-1 (Panx1) deficiency in mice and mutation in humans are also associated with hearing loss.
Chen, Jin, Liang, Chun, Zong, Liang, Zhu, Yan, Zhao, Hong-Bo   +4 more
openaire   +2 more sources

S-Nitrosylation Inhibits Pannexin 1 Channel Function [PDF]

Journal of Biological Chemistry, 2012
S-nitrosylation is a post-translational modification on cysteine(s) that can regulate protein function, and pannexin 1 (Panx1) channels are present in the vasculature, a tissue rich in nitric oxide (NO) species. Therefore, we investigated whether Panx1 can be S-nitrosylated and whether this modification can affect channel activity.
Alexander W, Lohman, Janelle L, Weaver, Marie, Billaud, Joanna K, Sandilos, Rachael, Griffiths, Adam C, Straub, Silvia, Penuela, Norbert, Leitinger, Dale W, Laird, Douglas A, Bayliss, Brant E, Isakson   +10 more
openaire   +2 more sources

Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism. [PDF]

PLoS ONE, 2014
P2X7 is a ligand-gated ion channel which is activated by ATP and displays secondary permeability characteristics. The mechanism of development of the secondary permeability pathway is currently unclear, although a role for the hemichannel protein ...
Archana Bhaskaracharya, Phuong Dao-Ung, Iman Jalilian, Mari Spildrejorde, Kristen K Skarratt, Stephen J Fuller, Ronald Sluyter, Leanne Stokes   +7 more
doaj   +1 more source

Probenecid slows disease progression in a murine model of autosomal dominant polycystic kidney disease

Physiological Reports, 2023
Development of autosomal dominant polycystic kidney disease (ADPKD) involves renal epithelial cell abnormalities. Cystic fluid contains a high level of ATP that, among other effects, leads to a reduced reabsorption of electrolytes in cyst‐lining cells ...
Sergey N. Arkhipov, D'Anna L. Potter, Regina F. Sultanova, Daria V. Ilatovskaya, Peter C. Harris, Tengis S. Pavlov   +5 more
doaj   +1 more source

Pannexin 1 deficiency can induce hearing loss [PDF]

Biochemical and Biophysical Research Communications, 2015
Gap junctions play a critical role in hearing. Connexin gap junction gene mutations can induce a high incidence of hearing loss. Pannexin (Panx) gene also encodes gap junction proteins in vertebrates. Panx1 is a predominant pannexin isoform and has extensive expression in the cochlea.
Hong-Bo, Zhao, Yan, Zhu, Chun, Liang, Jin, Chen   +3 more
openaire   +2 more sources

P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation. [PDF]

PLoS ONE, 2013
We have previously reported that Porphyromonas gingivalis infection of gingival epithelial cells (GEC) requires an exogenous danger signal such as ATP to activate an inflammasome and caspase-1, thereby inducing secretion of interleukin (IL)-1β ...
Shu-Chen Hung, Chul Hee Choi, Najwane Said-Sadier, Larry Johnson, Kalina Rosenova Atanasova, Hanen Sellami, Özlem Yilmaz, David M Ojcius   +7 more
doaj   +1 more source

Structural order in Pannexin 1 cytoplasmic domains [PDF]

Channels, 2014
Pannexin 1 forms ion and metabolite permeable hexameric channels with abundant expression in the central nervous system and elsewhere. Although pannexin 1 does not form intercellular channels, a common channel topology and oligomerization state, as well as involvement of the intracellular carboxyl terminal (CT) domain in channel gating, is shared with ...
Gaelle, Spagnol, Paul L, Sorgen, David C, Spray   +2 more
openaire   +2 more sources

Pannexin-1 Deficiency Decreases Epileptic Activity in Mice [PDF]

International Journal of Molecular Sciences, 2020
Objective: Pannexin-1 (Panx1) is suspected of having a critical role in modulating neuronal excitability and acute neurological insults. Herein, we assess the changes in behavioral and electrophysiological markers of excitability associated with Panx1 via three distinct models of epilepsy.
Mark S. Aquilino, Paige Whyte-Fagundes, Mark K. Lukewich, Liang Zhang, Berj L. Bardakjian, Georg R. Zoidl, Peter L. Carlen   +6 more
openaire   +3 more sources

Pannexin 1 activation and inhibition is permeant‐selective [PDF]

The Journal of Physiology, 2020
Key points The large‐pore channel pannexin 1 (Panx1) is expressed in many cell types and can open upon different, yet not fully established, stimuli. Panx1 permeability is often inferred from channel permeability to fluorescent dyes, but it is currently unknown whether dye permeability translates to permeability to other molecules. Cell shrinkage and C‐
Brian Skriver Nielsen, Trine Lisberg Toft‐Bertelsen, Sara Diana Lolansen, Connor L. Anderson, Morten Schak Nielsen, Roger J. Thompson, Nanna MacAulay   +6 more
openaire   +3 more sources

Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation

Neural Development, 2012
Background Pannexin 1 forms ion and metabolite permeable hexameric channels and is abundantly expressed in the brain. After discovering pannexin 1 expression in postnatal neural stem and progenitor cells we sought to elucidate its functional role in ...
Wicki-Stordeur Leigh E, Dzugalo Adrian D, Swansburg Rose M, Suits Jocelyne M, Swayne Leigh   +4 more
doaj   +1 more source