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Pannexin 1 in the Regulation of Vascular Tone [PDF]
Trends in Cardiovascular Medicine, 2012 Pannexins are a recently discovered protein family with the isoform Panx1 ubiquitously expressed and therefore extensively studied. Panx1 proteins form membrane channels known to release purines such as ATP. Because ATP and, more generally, purinergic signaling plays an important role in the vasculature, it became evident that Panx1 could have a key ...
Marie, Billaud +2 more
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Intrinsic properties and regulation of Pannexin 1 channel [PDF]
Channels, 2014 Pannexin 1 (Panx1) channels are generally represented as non-selective, large-pore channels that release ATP. Emerging roles have been described for Panx1 in mediating purinergic signaling in the normal nervous, cardiovascular, and immune systems, where they may be activated by mechanical stress, ionotropic and metabotropic receptor signaling, and via ...
Yu-Hsin, Chiu +2 more
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Frontiers in Molecular Neuroscience, 2017 Background: Accumulating evidence suggests that neuroinflammation plays a critical role in early brain injury after subarachnoid hemorrhage (SAH). Pannexin-1 channels, as a member of gap junction proteins located on the plasma membrane, releases ATP ...
Ling-Yun Wu +13 more
doaj +1 more source
International Journal of Oral Science, 2023 Severe muscle injury is hard to heal and always results in a poor prognosis. Recent studies found that extracellular vesicle-based therapy has promising prospects for regeneration medicine, however, whether extracellular vesicles have therapeutic effects
Qingyuan Ye +13 more
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PLoS ONE, 2021 Crohn's disease is a chronic inflammatory bowel disease and the NLRP3 inflammasome plays an important role in Crohn's disease. Previous studies have shown that Herb-partitioned moxibustion treating (at Qihai (CV 6) and Tianshu (ST 25)) prevented the ...
Ji Zhang +11 more
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Pannexin 1 in erythrocytes: Function without a gap [PDF]
Proceedings of the National Academy of Sciences, 2006 ATP is a widely used extracellular signaling molecule. The mechanism of ATP release from cells is presently unresolved and may be either vesicular or channel-mediated. Erythrocytes release ATP in response to low oxygen or to shear stress. In the absence of vesicles, the release has to be through channels. Erythrocytes do not form gap junctions.
Silviu, Locovei, Li, Bao, Gerhard, Dahl
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Emerging concepts regarding pannexin 1 in the vasculature [PDF]
Biochemical Society Transactions, 2015 Pannexin channels are newly discovered ATP release channels expressed throughout the body. Pannexin 1 (Panx1) channels have become of great interest as they appear to participate in a multitude of signalling cascades, including regulation of vascular function. Although numerous Panx1 pharmacological inhibitors have been discovered, these inhibitors are
Miranda E, Good +5 more
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Neurobiology of Disease, 2021 Human immunodeficiency virus-1 (HIV-1) has been shown to cross the blood-brain barrier and cause HIV-associated neurocognitive disorders (HAND) through a process that may involve direct or indirect interactions with the central nervous system (CNS) cells
Hyung Joon Cho +4 more
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Ecotoxicology and Environmental Safety, 2023 Respirable silica dust is a common hazard faced by occupational workers and prolonged exposure to this dust can lead to pulmonary inflammation, fibrosis and, in severe cases, silicosis.
Lin Zhang +3 more
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Pannexin 1 inhibition delays maturation and improves development of Bos taurus oocytes
Journal of Ovarian Research, 2020 Background Intercellular exchange between the oocyte and its surrounding cells within the follicular environment is critical for oocyte maturation and subsequent development.
Zachary Timothy Dye +3 more
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