Results 51 to 60 of about 5,216 (132)
P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases
Frontiers in Molecular Neuroscience, 2020 Shortage of oxygen and nutrients in the brain induces the release of glutamate and ATP that can cause excitotoxicity and contribute to neuronal and glial damage.
Abraham J. Cisneros-Mejorado +6 more
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Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2020 Introduction: Diabetes is one of the most common metabolic diseases that is associated with high blood sugar and can cause disorders of the central nervous system.
Mohammad Rami +3 more
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Pannexin-1 in Human Lymphatic Endothelial Cells Regulates Lymphangiogenesis [PDF]
International Journal of Molecular Sciences, 2018 The molecular mechanisms governing the formation of lymphatic vasculature are not yet well understood. Pannexins are transmembrane proteins that form channels which allow for diffusion of ions and small molecules (<1 kDa) between the extracellular space and the cytosol.
Boucher, Jonathan +7 more
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Mind the gap: connexins and pannexins in platelet function
Platelets, 2021 Connexins are a family of gap junction forming proteins widely expressed by mammalian cells. They assemble into hexameric hemichannels, which can either function independently or dock with opposing hemichannels on apposite cells, forming a gap junction ...
Kirk a Taylor +2 more
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Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival [PDF]
Nature Cell Biology, 2015 During metastatic progression, circulating cancer cells become lodged within the microvasculature of end organs, where most die from mechanical deformation. Although this phenomenon was first described over a half-century ago, the mechanisms enabling certain cells to survive this metastasis-suppressive barrier remain unknown.
Furlow, Paul W +8 more
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Pannexin 1 drives efficient epithelial repair after tissue injury
Science Immunology, 2022 Epithelial tissues such as lung and skin are exposed to the environment and therefore particularly vulnerable to damage during injury or infection. Rapid repair is therefore essential to restore function and organ homeostasis. Dysregulated epithelial tissue repair occurs in several human disease states, yet how individual cell types ...
Christopher D. Lucas +15 more
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The emerging Pannexin 1 signalome: a new nexus revealed?
Frontiers in Cellular Neuroscience, 2014 Pannexins (Panxs) are a family of single-membrane, large-pore ion and metabolite permeable channels. Of the three Panx proteins, Panx1 has been most extensively studied, and has recently emerged as an exciting, clinically relevant target in many ...
Leigh Elizabeth Wicki-Stordeur +4 more
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Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation [PDF]
Molecular & Cellular Oncology, 2019 Apoptosis can promote inflammation by triggering activation of the NLRP3 inflammasome (NLR family, pyrin domain containing 3). However, the molecular mechanisms regulating these processes are ill-defined. We recently reported that pannexin-1 is required to promote NLRP3 inflammasome assembly.
Benjamin Demarco +2 more
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Pannexin 1 Regulates Bidirectional Hippocampal Synaptic Plasticity in Adult Mice
Frontiers in Cellular Neuroscience, 2014 The threshold for bidirectional modification of synaptic plasticity is known to be controlled by several factors, including the balance between protein phosphorylation and dephosphorylation, postsynaptic free Ca2+ concentration and NMDA receptor (NMDAR ...
Alvaro O. Ardiles +10 more
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Revisiting multimodal activation and channel properties of Pannexin 1 [PDF]
Journal of General Physiology, 2017 Pannexin 1 (Panx1) forms plasma membrane ion channels that are widely expressed throughout the body. Panx1 activation results in the release of nucleotides such as adenosine triphosphate and uridine triphosphate. Thus, these channels have been implicated in diverse physiological and pathological functions associated with purinergic signaling, such as ...
Yu-Hsin Chiu +3 more
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