Results 61 to 70 of about 5,216 (132)

Deacetylation as a receptor-regulated direct activation switch for pannexin channels

Nature Communications, 2021
Pannexin 1 (PANX1) is a membrane channel mediating release of signaling molecules to the extracellular space. PANX1 can be activated by GPCRs. Here, the authors elucidate a non-canonical channel activation pathway by α1-adrenergic receptor that involves ...
Yu-Hsin Chiu, Christopher B. Medina, Catherine A. Doyle, Ming Zhou, Adishesh K. Narahari, Joanna K. Sandilos, Elizabeth C. Gonye, Hong-Yu Gao, Shih Yi Guo, Mahmut Parlak, Ulrike M. Lorenz, Thomas P. Conrads, Bimal N. Desai, Kodi S. Ravichandran, Douglas A. Bayliss   +14 more
doaj   +1 more source

Probenecid, a gout remedy, inhibits pannexin 1 channels

American Journal of Physiology-Cell Physiology, 2008
Probenecid is a well-established drug for the treatment of gout and is thought to act on an organic anion transporter, thereby affecting uric acid excretion in the kidney by blocking urate reuptake. Probenecid also has been shown to affect ATP release, leading to the suggestion that ATP release involves an organic anion transporter.
William, Silverman, Silviu, Locovei, Gerhard, Dahl   +2 more
openaire   +3 more sources

Blockade of Pannexin-1 Channels and Purinergic P2X7 Receptors Shows Protective Effects Against Cytokines-Induced Colitis of Human Colonic Mucosa

Frontiers in Pharmacology, 2018
Introduction: The pannexin-1 (Panx1) channels are found in many cell types, and ATP released from these channels can act on nearby cells activating purinergic P2X7 receptors (P2X7R) which lead to inflammation.
Erica F. Diezmos, Irit Markus, D. S. Perera, Steven Gan, Li Zhang, Shaun L. Sandow, Shaun L. Sandow, Paul P. Bertrand, Paul P. Bertrand, Lu Liu   +9 more
doaj   +1 more source

Baicalin inhibited PANX-1/P2Y6 signaling pathway activation in porcine aortic vascular endothelial cells infected by Glaesserella parasuis

Heliyon
Glaesserella parasuis can induce endothelial barrier damage in piglets, although the mechanism by which this pathogen triggers inflammatory damage remains unclear. Baicalin possesses anti-inflammatory and anti-oxidant activities.
Shulin Fu, Xinyue Tian, Chun Peng, Dan Zhang, Linglu Zhou, Yuzhen Yuan, Jing He, Ling Guo, Yinsheng Qiu, Chun Ye, Yu Liu, Bingbing Zong   +11 more
doaj   +1 more source

تأثیر تمرینات HIIT بر تغییرات Pannexin-1،P2X7، NLRP-1 بافت قلب موش‌های صحرایی نر نژاد ویستار مبتلا به دیابت نوع 2 [PDF]

مجله دانشکده پزشکی اصفهان
مقاله پژوهشیمقدمه: هدف پژوهش حاضر، مطالعه‌ی تأثیر تمرینات HIIT بر تغییرات سطوح پروتئین‌های Pannexin-1، P2X7، NLRP-1 بافت قلب موش‌های صحرایی نر نژاد ویستار مبتلا به دیابت نوع 2 می‌باشد.روش‌ها: در این مطالعه، تعداد 40 سر موش صحرایی نر 8 هفته‌ای از نژاد ...
یاسمن رفیعی, علی اکبر علی زاده, سعید شاکریان, امیرحسین رمضانی احمدی   +3 more
doaj   +1 more source

The two faces of pannexins: new roles in inflammation and repair

Journal of Inflammation Research, 2018
Helen P Makarenkova,1 Sameer B Shah,2,3 Valery I Shestopalov4–6 1Department of Molecular Medicine, Scripps Research Institute, 2Departments of Orthopaedic Surgery and Bioengineering, University of California, 3Research Division, Veterans Affairs ...
Makarenkova HP, Shah SB, Shestopalov VI
doaj  

ATP-release pannexin channels are gated by lysophospholipids

eLife
In addition to its role as cellular energy currency, adenosine triphosphate (ATP) serves as an extracellular messenger that mediates diverse cell-to-cell communication.
Erik Henze, Russell N Burkhardt, Bennett William Fox, Tyler J Schwertfeger, Eric Gelsleichter, Kevin Michalski, Lydia Kramer, Margret Lenfest, Jordyn M Boesch, Hening Lin, Frank C Schroeder, Toshimitsu Kawate   +11 more
doaj   +1 more source

Pannexin 1 sustains the electrophysiological responsiveness of retinal ganglion cells

Scientific Reports, 2018
Pannexin 1 (Panx1) forms ATP-permeable membrane channels that play a key role in purinergic signaling in the nervous system in both normal and pathological conditions.
Galina Dvoriantchikova, Alexey Pronin, Sarah Kurtenbach, Abduqodir Toychiev, Tsung-Han Chou, Christopher W. Yee, Breanne Prindeville, Junior Tayou, Vittorio Porciatti, Botir T. Sagdullaev, Vladlen Z. Slepak, Valery I. Shestopalov   +11 more
doaj   +1 more source

The Role of Pannexin-1 Channel- Review

, 2022
Three relations compose the Pannexin family of channel forming glycoproteins such as Pannexin-1 (Panx1, Gen-Bank AAQ89382.1, 426 amino-acids), Pannexin-2 (Panx2, Gen-Bank AAI01024.1, 74.4 kDa) and Pannexin-3 (Panx3, Gen-Bank AAK95655.1, 392 aminoacids, 44.7 kDa). Their primary performance is outlined by their capability to make single membrane channels
openaire   +1 more source

Cryo-EM structures of human pannexin 1 channel  [PDF]

Cell Research, 2020
Qiuheng Jin, Bo Zhang, Xiang Zheng, Ningning Li, Lingyi Xu, Yuan Xie, Fangjun Song, Eijaz Ahmed Bhat, Yuan Chen, Ning Gao, Jiangtao Guo, Xiaokang Zhang, Sheng Ye   +12 more
openaire   +2 more sources