Results 91 to 100 of about 27,134,532 (169)
Ecotoxicology and Environmental Safety, 2023 Respirable silica dust is a common hazard faced by occupational workers and prolonged exposure to this dust can lead to pulmonary inflammation, fibrosis and, in severe cases, silicosis.
Lin Zhang +3 more
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Cell Proliferation, Volume 59, Issue 2, February 2026.Mitochondrial quality control (MQC) impairment plays a central role in driving the pathogenesis of metabolism‐associated steatotic liver disease (MASLD). Specifically, this is manifested as reduced mitophagy; increased mitochondrial fission and decreased fusion; and impaired mitochondrial biogenesis.
Wenkai Fu +8 more
wiley +1 more source
N-Glycosylation Regulates Pannexin 2 Localization but Is Not Required for Interacting with Pannexin 1 [PDF]
International Journal of Molecular Sciences, 2018 Pannexins (Panx1, 2, 3) are channel-forming glycoproteins expressed in mammalian tissues. We previously reported that N-glycosylation acts as a regulator of the localization and intermixing of Panx1 and Panx3, but its effects on Panx2 are currently unknown.
Rafael E. Sanchez-Pupo +2 more
openaire +4 more sources
Genes, Brain and Behavior, Volume 25, Issue 1, February 2026.Buccal ganglia inter‐ and motoneuronal transcriptional changes were investigated after learning food is inedible (LFI) in Aplysia californica reared on different diets at two ages. Those reared on calorie restriction showed delayed signs of aging and maintained their performance in LFI when aged while those reared on ad‐lib did not. ABSTRACT Along with
Eric C. Randolph, Lynne A. Fieber
wiley +1 more source
P2X7 Receptors as a Therapeutic Target in Cerebrovascular Diseases
Frontiers in Molecular Neuroscience, 2020 Shortage of oxygen and nutrients in the brain induces the release of glutamate and ATP that can cause excitotoxicity and contribute to neuronal and glial damage.
Abraham J. Cisneros-Mejorado +6 more
doaj +1 more source
The Journal of Physiology, Volume 604, Issue 4, Page 1592-1606, 15 February 2026.Abstract figure legend Intricate cellular electrical coupling networks in the heart. Various cell types couple the central cardiomyocyte through gap junctional contacts, with the exception of neurons. Whether ephaptic coupling (EpC) occurs in homocellular or heterocellular contexts beyond cardiomyocyte–cardiomyocyte interactions remains unclear ...
Xiaobo Wu +2 more
wiley +1 more source
Powerful partnership: crosstalk between pannexin 1 and the cytoskeleton
Frontiers in Physiology, 2014 Pannexin 1 (Panx1) large-pore ion and metabolite channels are emerging as key proteins in many physiological and pathophysiological scenarios. Recent evidence has tightly linked Panx1 trafficking and function to the cytoskeleton, a multi-component ...
Andrew Kenneth Jameson Boyce +5 more
doaj +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
The emerging Pannexin 1 signalome: a new nexus revealed?
Frontiers in Cellular Neuroscience, 2014 Pannexins (Panxs) are a family of single-membrane, large-pore ion and metabolite permeable channels. Of the three Panx proteins, Panx1 has been most extensively studied, and has recently emerged as an exciting, clinically relevant target in many ...
Leigh Elizabeth Wicki-Stordeur +4 more
doaj +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin +14 more
wiley +1 more source