A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP
, 2009 Pannexin 1 forms a large membrane channel that, based on its biophysical properties and its expression pattern, is a prime candidate to represent an ATP release channel. Pannexin 1 channel activity is potentially deleterious for cells as indicated by its
Dahl, Gerhard, Qiu, Feng
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ATP-release pannexin channels are gated by lysophospholipids
eLifeIn addition to its role as cellular energy currency, adenosine triphosphate (ATP) serves as an extracellular messenger that mediates diverse cell-to-cell communication.
Erik Henze +11 more
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The two faces of pannexins: new roles in inflammation and repair
Journal of Inflammation Research, 2018 Helen P Makarenkova,1 Sameer B Shah,2,3 Valery I Shestopalov4–6 1Department of Molecular Medicine, Scripps Research Institute, 2Departments of Orthopaedic Surgery and Bioengineering, University of California, 3Research Division, Veterans Affairs ...
Makarenkova HP, Shah SB, Shestopalov VI
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تأثیر تمرینات HIIT بر تغییرات Pannexin-1،P2X7، NLRP-1 بافت قلب موشهای صحرایی نر نژاد ویستار مبتلا به دیابت نوع 2 [PDF]
مجله دانشکده پزشکی اصفهانمقاله پژوهشیمقدمه: هدف پژوهش حاضر، مطالعهی تأثیر تمرینات HIIT بر تغییرات سطوح پروتئینهای Pannexin-1، P2X7، NLRP-1 بافت قلب موشهای صحرایی نر نژاد ویستار مبتلا به دیابت نوع 2 میباشد.روشها: در این مطالعه، تعداد 40 سر موش صحرایی نر 8 هفتهای از نژاد ...
یاسمن رفیعی +3 more
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The Role of Pannexin-1 Channel- Review
, 2022 Three relations compose the Pannexin family of channel forming glycoproteins such as Pannexin-1 (Panx1, Gen-Bank AAQ89382.1, 426 amino-acids), Pannexin-2 (Panx2, Gen-Bank AAI01024.1, 74.4 kDa) and Pannexin-3 (Panx3, Gen-Bank AAK95655.1, 392 aminoacids, 44.7 kDa). Their primary performance is outlined by their capability to make single membrane channels
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Physiological mechanisms for the modulation of pannexin 1 channel activity
The Journal of Physiology, 2012 Abstract It is widely recognized that ATP, along with other nucleotides, subserves important intercellular signalling processes. Among various nucleotide release mechanisms, the relatively recently identified pannexin 1 (Panx1) channel is gaining prominence by virtue of its ability to support nucleotide permeation and release in a variety of different ...
Joanna K, Sandilos, Douglas A, Bayliss
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Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling [PDF]
, 2007 SummaryCryopyrin is essential for caspase-1 activation triggered by Toll-like receptor (TLR) ligands in the presence of adenosine triphosphate (ATP). However, the events linking bacterial products and ATP to cryopyrin remain unclear.
Kim, Yun-Gi +23 more
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Differential role of the pannexin-1/ATP/P2X7 axis in IL-1β release by human monocytes [PDF]
, 2017 IL - 1 β release is integral to the innate immune system. The release of mature IL - 1 β depends on two regulated events; (i) the de novo induction of pro - IL - 1 β , generally via NF κ B - depend ent transduction pathways and (ii) the assembly ...
Mark J. Paul‐Clark +17 more
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Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation
, 2011 Apoptotic cell death is important for embryonic development, immune cell homeostasis, and pathogen elimination. Innate immune cells also undergo a very rapid form of cell death termed pyroptosis after activating the protease caspase-1.
Shahram Misaghi +8 more
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Pannexin 1 sustains the electrophysiological responsiveness of retinal ganglion cells
Scientific Reports, 2018 Pannexin 1 (Panx1) forms ATP-permeable membrane channels that play a key role in purinergic signaling in the nervous system in both normal and pathological conditions.
Galina Dvoriantchikova +11 more
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