Results 71 to 80 of about 29,697,258 (185)
Cancer Medicine, Volume 15, Issue 9, September 2026.ABSTRACT Resistance to immune checkpoint blockade (ICB) remains a major barrier in cancer therapy, reflecting the fact that tumor immunity is governed not only by cell type abundance but also by spatial organization and temporal dynamics within the tumor microenvironment (TME).
Shanyi Li +4 more
wiley +1 more source
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2020 Introduction: Diabetes is one of the most common metabolic diseases that is associated with high blood sugar and can cause disorders of the central nervous system.
Mohammad Rami +3 more
doaj
Frontiers in Cellular Neuroscience, 2020 Synaptic loss induced by soluble oligomeric forms of the amyloid β peptide (sAβos) is one of the earliest events in Alzheimer’s disease (AD) and is thought to be the major cause of the cognitive deficits.
Carolina Flores-Muñoz +25 more
doaj +1 more source
Neurobiology of Disease, 2021 Human immunodeficiency virus-1 (HIV-1) has been shown to cross the blood-brain barrier and cause HIV-associated neurocognitive disorders (HAND) through a process that may involve direct or indirect interactions with the central nervous system (CNS) cells
Hyung Joon Cho +4 more
doaj +1 more source
Migraine: Epidemiology, Risk Factors, Pathophysiology, and Treatment
MedComm, Volume 7, Issue 9, September 2026.Migraine is a highly prevalent, female‐predominant, and disabling brain disorder shaped by genetic susceptibility, hormonal influences, modifiable attack factors, and comorbidity‐related progression. This review integrates current evidence on migraine epidemiology, phase‐specific neurovascular and neuroglial mechanisms, including CGRP signaling and ...
Weiwei Lu +9 more
wiley +1 more source
Revisiting multimodal activation and channel properties of Pannexin 1 [PDF]
Journal of General Physiology, 2017 Pannexin 1 (Panx1) forms plasma membrane ion channels that are widely expressed throughout the body. Panx1 activation results in the release of nucleotides such as adenosine triphosphate and uridine triphosphate. Thus, these channels have been implicated in diverse physiological and pathological functions associated with purinergic signaling, such as ...
Yu-Hsin Chiu +3 more
openaire +2 more sources
Advanced Science, Volume 13, Issue 44, 7 August 2026.ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen +7 more
wiley +1 more source
Activation of pannexin-1 mediates triglyceride-induced macrophage cell death. [PDF]
, 2020 The accumulation of triglycerides (TGs) in macrophages induces cell death, a risk factor in the pathogenesis of atherosclerosis. We had previously reported that TG-induced macrophage death is triggered by caspase-1 and -2, therefore we investigated the ...
Kim, Sung +3 more
core +1 more source
Pannexin 1 inhibition delays maturation and improves development of Bos taurus oocytes
Journal of Ovarian Research, 2020 Background Intercellular exchange between the oocyte and its surrounding cells within the follicular environment is critical for oocyte maturation and subsequent development.
Zachary Timothy Dye +3 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2023 Respirable silica dust is a common hazard faced by occupational workers and prolonged exposure to this dust can lead to pulmonary inflammation, fibrosis and, in severe cases, silicosis.
Lin Zhang +3 more
doaj +1 more source