Results 61 to 70 of about 5,402 (167)

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes [PDF]

Journal of Biological Chemistry, 2009
The inflammasome is a multiprotein complex involved in innate immunity. Activation of the inflammasome causes the processing and release of the cytokines interleukins 1beta and 18. In primary macrophages, potassium ion flux and the membrane channel pannexin 1 have been suggested to play roles in inflammasome activation. However, the molecular mechanism(
William R, Silverman, Juan Pablo, de Rivero Vaccari, Silviu, Locovei, Feng, Qiu, Steven K, Carlsson, Eliana, Scemes, Robert W, Keane, Gerhard, Dahl   +7 more
openaire   +2 more sources

The Multifaceted Role of Pyroptosis: Molecular Mechanisms, Crosstalk with Other Cell Death Pathways, and Therapeutic Implications

MedComm, Volume 7, Issue 7, July 2026.
Pyroptosis maintains immune homeostasis by eliminating damaged or infected cells, but its dysregulation promotes inflammation and cancer progression. The diagram illustrates key activation pathways, links with other programmed cell deaths, and cancer‐specific effects, enhancing its dual protective and pathogenic roles.
Diego Liviu Boaru, Patricia De Castro‐Martinez, Cielo Garcia‐Montero, Oscar Fraile‐Martinez, Majd N. Michael Alhaddadin, Silvestra Barrena‐Blázquez, Laura Lopez‐Gonzalez, Clara Tasende Fernández, Ricardo Alvarado‐Hurtado, Tomás Ratia Giménez, Inmaculada Lasa‐Unzúe, Manuel Díez Alonso, Alberto Gutiérrez‐Calvo, Miguel A. Saez, David Cobo‐Prieto, Jose V. Saz, Melchor Alvarez‐Mon, Raul Diaz‐Pedrero, Miguel A. Ortega   +18 more
wiley   +1 more source

Pannexin-1 as a potentiator of ligand-gated receptor signaling [PDF]

Channels, 2014
Pannexins are a class of plasma membrane spanning proteins that presumably form a hexameric, non-selective ion channel. Although similar in secondary structure to the connexins, pannexins notably do not form endogenous gap junctions and act as bona fide ion channels.
Isakson, Brant E, Thompson, Roger J
openaire   +2 more sources

Pannexin 1 inhibition delays maturation and improves development of Bos taurus oocytes

Journal of Ovarian Research, 2020
Background Intercellular exchange between the oocyte and its surrounding cells within the follicular environment is critical for oocyte maturation and subsequent development.
Zachary Timothy Dye, Lauren Virginia Rutledge, Silvia Penuela, Paul William Dyce   +3 more
doaj   +1 more source

Mechanistic insights into severe pulmonary inflammation caused by silica stimulation: The role of macrophage pyroptosis

Ecotoxicology and Environmental Safety, 2023
Respirable silica dust is a common hazard faced by occupational workers and prolonged exposure to this dust can lead to pulmonary inflammation, fibrosis and, in severe cases, silicosis.
Lin Zhang, Jiaqi Tian, Lan Ma, Shuyin Duan   +3 more
doaj   +1 more source

When can AlphaFold predict the oligomeric states of proteins?

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Homooligomerisation is a prevalent and important process that many proteins undergo to form the quaternary structures required for biological function. However, determining oligomeric states and structures experimentally remains technically challenging and time‐consuming for many proteins.
Yiechang Lin, Ciara Wallis, Ben Corry
wiley   +1 more source

Multifaceted Role of Extracellular Vesicles: Intercellular Messengers to Therapeutic Applications: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and cell differentiation.
Kajal Kamra, Satya Kumar Lalam, Shefali Srivastava, Madan Kumar Arumugam, Lokesh Kumar Boopathy, Simran Takkar, Zhiqiu Xia, Sabarinath Peruvemba Subramanian   +7 more
wiley   +1 more source

Exacerbated ATP transmission in the carotid body is linked to glomus cell expansion in spontaneously hypertensive rats

The Journal of Physiology, Volume 604, Issue 12, Page 4678-4706, 15 June 2026.
Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe, Audrys Pauza, Olivia M. S. Gold, Xin Shen, Fernanda Brognara, Rosanna Roberts Nonu, Dylan K. Pen, Aabharika Bose, Emma N. Bardsley, Anna P. Ponnampalam, Davi J. A. Moraes, Julian F. R. Paton   +11 more
wiley   +1 more source

S-Nitrosylation Inhibits Pannexin 1 Channel Function [PDF]

Journal of Biological Chemistry, 2012
S-nitrosylation is a post-translational modification on cysteine(s) that can regulate protein function, and pannexin 1 (Panx1) channels are present in the vasculature, a tissue rich in nitric oxide (NO) species. Therefore, we investigated whether Panx1 can be S-nitrosylated and whether this modification can affect channel activity.
Alexander W, Lohman, Janelle L, Weaver, Marie, Billaud, Joanna K, Sandilos, Rachael, Griffiths, Adam C, Straub, Silvia, Penuela, Norbert, Leitinger, Dale W, Laird, Douglas A, Bayliss, Brant E, Isakson   +10 more
openaire   +2 more sources

The emerging Pannexin 1 signalome: a new nexus revealed?

Frontiers in Cellular Neuroscience, 2014
Pannexins (Panxs) are a family of single-membrane, large-pore ion and metabolite permeable channels. Of the three Panx proteins, Panx1 has been most extensively studied, and has recently emerged as an exciting, clinically relevant target in many ...
Leigh Elizabeth Wicki-Stordeur, Leigh Anne eSwayne, Leigh Anne eSwayne, Leigh Anne eSwayne, Leigh Anne eSwayne   +4 more
doaj   +1 more source