Results 41 to 50 of about 29,697,258 (185)
Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis
eLife, 2020 ATP is essential for all living cells. However, how dead cells lose ATP has not been well investigated. In this study, we developed new FRET biosensors for dual imaging of intracellular ATP level and caspase-3 activity in single apoptotic cultured human ...
Hiromi Imamura +8 more
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Biomedicines, 2022 Pannexins are transmembrane glycoproteins that constitute channels involved in purinergic signaling through ATP release from cells in various physiological and pathological processes.
Ivo Jeličić +6 more
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Knockout of Pannexin-1 Induces Hearing Loss [PDF]
International Journal of Molecular Sciences, 2018 Mutations of gap junction connexin genes induce a high incidence of nonsyndromic hearing loss. Pannexin genes also encode gap junctional proteins in vertebrates. Recent studies demonstrated that Pannexin-1 (Panx1) deficiency in mice and mutation in humans are also associated with hearing loss.
Chen, Jin +4 more
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Functional implications of calcium permeability of the channel formed by pannexin 1. [PDF]
, 2006 Although human pannexins (PanX) are homologous to gap junction molecules, their physiological function in vertebrates remains poorly understood. Our results demonstrate that overexpression of PanX1 results in the formation of Ca(2+)-permeable gap ...
Ivanov, Dmitry, V +31 more
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Intrinsic properties and regulation of Pannexin 1 channel [PDF]
Channels, 2014 Pannexin 1 (Panx1) channels are generally represented as non-selective, large-pore channels that release ATP. Emerging roles have been described for Panx1 in mediating purinergic signaling in the normal nervous, cardiovascular, and immune systems, where they may be activated by mechanical stress, ionotropic and metabotropic receptor signaling, and via ...
Yu-Hsin, Chiu +2 more
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Biomedicines, 2023 Probenecid is an old uricosuric agent used in clinics to treat gout and reduce the renal excretion of antibiotics. In recent years, probenecid has gained attention due to its ability to interact with membrane proteins such as TRPV2 channels, organic ...
Claudia García-Rodríguez +7 more
doaj +1 more source
Pannexin-1 channel regulates nuclear content packaging into apoptotic bodies and their size
, 2021 Apoptotic bodies (ApoBDs), which are large extracellular vesicles exclusively released by apoptotic cells, possess therapeutically exploitable properties including biomolecule loadability and transferability.
Ivan Poon (9481238) +7 more
core +1 more source
Airway Epithelial Nucleotide Release Contributes to Mucociliary Clearance
Life, 2021 Mucociliary clearance (MCC) is a dominant component of pulmonary host defense. In health, the periciliary layer (PCL) is optimally hydrated, thus acting as an efficient lubricant layer over which the mucus layer moves by ciliary force.
Catharina van Heusden +3 more
doaj +1 more source
Pannexin 1 and Pannexin 3 Channels Regulate Skeletal Muscle Myoblast Proliferation and Differentiation [PDF]
Journal of Biological Chemistry, 2014 Pannexins constitute a family of three glycoproteins (Panx1, -2, and -3) forming single membrane channels. Recent work demonstrated that Panx1 is expressed in skeletal muscle and involved in the potentiation of contraction. However, Panxs functions in skeletal muscle cell differentiation, and proliferation had yet to be assessed.
Langlois, Stéphanie +5 more
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Structural order in Pannexin 1 cytoplasmic domains [PDF]
Channels, 2014 Pannexin 1 forms ion and metabolite permeable hexameric channels with abundant expression in the central nervous system and elsewhere. Although pannexin 1 does not form intercellular channels, a common channel topology and oligomerization state, as well as involvement of the intracellular carboxyl terminal (CT) domain in channel gating, is shared with ...
Gaelle, Spagnol +2 more
openaire +2 more sources