Results 31 to 40 of about 29,697,258 (185)

Pannexin 1 in the Regulation of Vascular Tone [PDF]

Trends in Cardiovascular Medicine, 2012
Pannexins are a recently discovered protein family with the isoform Panx1 ubiquitously expressed and therefore extensively studied. Panx1 proteins form membrane channels known to release purines such as ATP. Because ATP and, more generally, purinergic signaling plays an important role in the vasculature, it became evident that Panx1 could have a key ...
Marie, Billaud, Joanna K, Sandilos, Brant E, Isakson   +2 more
openaire   +2 more sources

Probenecid-Blocked Pannexin-1 Channel Protects Against Early Brain Injury via Inhibiting Neuronal AIM2 Inflammasome Activation After Subarachnoid Hemorrhage

Frontiers in Neurology, 2022
AimPrevious studies have proved that inhibiting inflammasome activation provides neuroprotection against early brain injury (EBI) after subarachnoid hemorrhage (SAH), which is mainly focused on the microglial inflammatory response, but the potential role
Yonghe Zheng, Wenwen Tang, Hanhai Zeng, Yucong Peng, Xiaobo Yu, Feng Yan, Shenglong Cao   +6 more
doaj   +1 more source

Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism. [PDF]

PLoS ONE, 2014
P2X7 is a ligand-gated ion channel which is activated by ATP and displays secondary permeability characteristics. The mechanism of development of the secondary permeability pathway is currently unclear, although a role for the hemichannel protein ...
Archana Bhaskaracharya, Phuong Dao-Ung, Iman Jalilian, Mari Spildrejorde, Kristen K Skarratt, Stephen J Fuller, Ronald Sluyter, Leanne Stokes   +7 more
doaj   +1 more source

Probenecid slows disease progression in a murine model of autosomal dominant polycystic kidney disease

Physiological Reports, 2023
Development of autosomal dominant polycystic kidney disease (ADPKD) involves renal epithelial cell abnormalities. Cystic fluid contains a high level of ATP that, among other effects, leads to a reduced reabsorption of electrolytes in cyst‐lining cells ...
Sergey N. Arkhipov, D'Anna L. Potter, Regina F. Sultanova, Daria V. Ilatovskaya, Peter C. Harris, Tengis S. Pavlov   +5 more
doaj   +1 more source

Pannexin 1 activation and inhibition is permeant‐selective [PDF]

The Journal of Physiology, 2020
Key points The large‐pore channel pannexin 1 (Panx1) is expressed in many cell types and can open upon different, yet not fully established, stimuli. Panx1 permeability is often inferred from channel permeability to fluorescent dyes, but it is currently unknown whether dye permeability translates to permeability to other molecules. Cell shrinkage and C‐
Brian Skriver Nielsen, Trine Lisberg Toft‐Bertelsen, Sara Diana Lolansen, Connor L. Anderson, Morten Schak Nielsen, Roger J. Thompson, Nanna MacAulay   +6 more
openaire   +3 more sources

P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation. [PDF]

PLoS ONE, 2013
We have previously reported that Porphyromonas gingivalis infection of gingival epithelial cells (GEC) requires an exogenous danger signal such as ATP to activate an inflammasome and caspase-1, thereby inducing secretion of interleukin (IL)-1β ...
Shu-Chen Hung, Chul Hee Choi, Najwane Said-Sadier, Larry Johnson, Kalina Rosenova Atanasova, Hanen Sellami, Özlem Yilmaz, David M Ojcius   +7 more
doaj   +1 more source

Dual Regulatory Roles of Pannexin 1 in the Pathogenesis and Recovery of Sepsis-Induced Acute Lung Injury. [PDF]

Infect Drug Resist
Qiancheng Xu,1,* Yan Qian,2,* Yingya Cao,1 Weihua Lu,1 Jianguo Li3 1Department of Critical Care Medicine, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), Wuhu, Anhui, 241000, People’s
Xu Q, Qian Y, Cao Y, Lu W, Li J.
europepmc   +2 more sources

Novel Naphthyridones Targeting Pannexin 1 for Colitis Management. [PDF]

Adv Sci (Weinh)
Abstract Pannexin 1 (PANX1) forms cell-surface channels capable of releasing signaling metabolites for diverse patho-physiological processes. While inhibiting dysregulated PANX1 is proposed as a therapeutic strategy for many pathological conditions, including inflammatory bowel disease (IBD), low efficacy or poor ...
Hsueh WY, Wu YL, Weng MT, Liu SY, Santavanond JP, Liu YC, Lin CI, Lai CN, Lu YR, Hsu JY, Gao HY, Lee JC, Wei SC, Lyu PC, Poon IKH, Hsieh HP, Chiu YH.   +16 more
europepmc   +3 more sources

Pannexin 1: The Molecular Substrate of Astrocyte “Hemichannels” [PDF]

The Journal of Neuroscience, 2009
Purinergic signaling plays distinct and important roles in the CNS, including the transmission of calcium signals between astrocytes. Gap junction hemichannels are among the mechanisms proposed by which astrocytes might release ATP; however, whether the gap junction protein connexin43 (Cx43) forms these “hemichannels” remains controversial. Recently, a
Rodolfo, Iglesias, Gerhard, Dahl, Feng, Qiu, David C, Spray, Eliana, Scemes   +4 more
openaire   +2 more sources

Identification of Pannexins in Rat Nasal Mucosa

Allergy & Rhinology, 2013
Pannexins are a second family of gap-junction proteins in vertebrates, classified as pannexin-1, pannexin-2, and pannexin-3. Pannexin-1 is one of the candidates for channel-mediated ATP release into the extracellular space.
Toyoaki Ohbuchi M.D., Nobusuke Hohchi M.D., Jun-ichi Ohkubo M.D., Koichi Hashida M.D., Hiroki Koizumi M.D., Tetsuro Wakasugi M.D., Fumiko Takenaga M.D., Hideaki Suzuki M.D., Ph.D.   +7 more
doaj   +1 more source