Results 11 to 20 of about 29,697,258 (185)
Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns
PLoS Biology, 2022 Astroglial release of molecules is thought to actively modulate neuronal activity, but the nature, release pathway, and cellular targets of these neuroactive molecules are still unclear.
Flora Vasile +10 more
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Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation [PDF]
Neural Development, 2012 Background Pannexin 1 forms ion and metabolite permeable hexameric channels and is abundantly expressed in the brain. After discovering pannexin 1 expression in postnatal neural stem and progenitor cells we sought to elucidate its functional role in ...
Wicki-Stordeur Leigh E +4 more
doaj +2 more sources
Pannexin 1 channels in skeletal muscles [PDF]
Frontiers in Physiology, 2014 Normal myotubes and adult innervated skeletal myofibers express the glycoprotein pannexin1 (Panx1). Six of them form a gap junction hemichannel-like structure that connects the cytoplasm with the extracellular space; here they will be called Panx1 ...
Luis Andrés Cea +6 more
doaj +5 more sources
Emerging functions of Pannexin 1 in the eye [PDF]
Frontiers in Cellular Neuroscience, 2014 Pannexin 1 (Panx1) is a high-conductance, voltage-gated channel protein found in vertebrates. It has been shown that Panx1 is widely expressed in many organs and tissues, including sensory systems.
Sarah eKurtenbach +2 more
doaj +3 more sources
Ubiquitination and Proteasomal Regulation of Pannexin 1 and Pannexin 3
, 2020 Pannexin 1 (PANX1) and Pannexin 3 (PANX3) are single-membrane channel glycoproteins that allow for communication between the cell and its environment to regulate cellular differentiation, proliferation, and apoptosis. Their expression is regulated through post-translational modifications, however, their regulation by ubiquitination and the ubiquitin ...
Blinder, Anna
openaire +3 more sources
Pannexin 1 Influences Lineage Specification of Human iPSCs [PDF]
Frontiers in Cell and Developmental Biology, 2021 Every single cell in the body communicates with nearby cells to locally organize activities with their neighbors and dysfunctional cell-cell communication can be detrimental during cell lineage commitment, tissue patterning and organ development ...
Rebecca J. Noort +2 more
doaj +5 more sources
Perspectives on the role of Pannexin 1 in neural precursor cell biology
Neural Regeneration Research, 2016 We recently reported that targeted deletion of Pannexin 1 in neural precursor cells of the ventricular zone impairs the maintenance of these cells in healthy and stroke-injured brain. Here we frame this exciting new finding in the context of our previous
Juan C Sanchez-Arias +2 more
doaj +2 more sources
Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves [PDF]
Frontiers in Cellular Neuroscience, 2017 The pannexin family of channels consists of three members—pannexin-1 (Panx1), pannexin-2 (Panx2), and pannexin-3 (Panx3) that enable the exchange of metabolites and signaling molecules between intracellular and extracellular compartments.
Steven M. Horton +10 more
doaj +3 more sources
The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes [PDF]
Journal of Biological Chemistry, 2009 The inflammasome is a multiprotein complex involved in innate immunity. Activation of the inflammasome causes the processing and release of the cytokines interleukins 1beta and 18. In primary macrophages, potassium ion flux and the membrane channel pannexin 1 have been suggested to play roles in inflammasome activation. However, the molecular mechanism(
William R, Silverman +7 more
openaire +3 more sources
Low levels of pannexin‐1 in Behçet’s syndrome
International Journal of Rheumatic Diseases, 2019 AbstractObjectiveBehçet's syndrome (BS) is a chronic, multisystemic and inflammatory syndrome. In our study, we aimed to compare the initiator, effector and inflammatory caspases and pannexin channel protein, which is thought to have an activity in inflammation, in the inflammatory process of BS, with healthy subjects, to investigate their level in ...
Ali Şahin +4 more
core +5 more sources