Results 11 to 20 of about 27,134,532 (169)

Novel Naphthyridones Targeting Pannexin 1 for Colitis Management. [PDF]

Adv Sci (Weinh)
Pannexin 1 (PANX1) forms cell-surface channels capable of releasing signaling metabolites for diverse patho-physiological processes. While inhibiting dysregulated PANX1 is proposed as a therapeutic strategy for many pathological conditions, including ...
Hsueh WY, Wu YL, Weng MT, Liu SY, Santavanond JP, Liu YC, Lin CI, Lai CN, Lu YR, Hsu JY, Gao HY, Lee JC, Wei SC, Lyu PC, Poon IKH, Hsieh HP, Chiu YH.   +16 more
europepmc   +4 more sources

Pannexin-1 Modulates Inhibitory Transmission and Hippocampal Synaptic Plasticity. [PDF]

Biomolecules, 2023
Pannexin-1 (Panx1) hemichannel is a non-selective transmembrane channel that may play important roles in intercellular signaling by allowing the permeation of ions and metabolites, such as ATP. Although recent evidence shows that the Panx1 hemichannel is
García-Rojas F, Flores-Muñoz C, Santander O, Solis P, Martínez AD, Ardiles ÁO, Fuenzalida M.   +6 more
europepmc   +5 more sources

Pannexin 1 and pannexin 3 differentially regulate the cancer cell properties of cutaneous squamous cell carcinoma. [PDF]

J Physiol
Pannexin (PANX) channels are present in skin and facilitate the movement of signalling molecules during cellular communication. PANX1 and PANX3 function in skin homeostasis and keratinocyte differentiation but were previously reduced in a small cohort of
O'Donnell BL, Johnston D, Bhatt A, Kardan Z, Stefan D, Bysice A, Sayedyahossein S, Dagnino L, Cecchini M, Loganathan SK, Roth K, Penuela S.   +11 more
europepmc   +4 more sources

Pannexin 1 channels in skeletal muscles [PDF]

Frontiers in Physiology, 2014
Normal myotubes and adult innervated skeletal myofibers express the glycoprotein pannexin1 (Panx1). Six of them form a gap junction hemichannel-like structure that connects the cytoplasm with the extracellular space; here they will be called Panx1 ...
Luis Andrés Cea, Manuel Antonio Riquelme, Aníbal A Vargas, Aníbal A Vargas, Carolina eUrrutia, Juan C Saez, Juan C Saez   +6 more
doaj   +5 more sources

Proximal tubule pannexin 1 contributes to mitochondrial dysfunction and cell death during acute kidney injury. [PDF]

Am J Physiol Renal Physiol
Pannexin 1 (Panx1) is a membrane-associated channel that, when activated, facilitates the release of small metabolites into the extracellular environment.
Poudel N, Zheng S, Skrypnyk N, Sung SJ, Goggins E, Nash WT, Pavelec C, Yee M, Balogun I, Medina CB, Yao J, Rosin DL, Leitinger N, Ravichandran KS, Okusa MD.   +14 more
europepmc   +2 more sources

A metastasis-associated pannexin-1 mutant (Panx1^1-89) forms a minimalist ATP release channel. [PDF]

FEBS J
A truncated form of the ATP release channel pannexin 1 (Panx1), Panx11–89, is enriched in metastatic breast cancer cells and has been proposed to mediate metastatic cell survival by increasing ATP release through mechanosensitive Panx1 channels. However,
Wang J, Levi NJ, Diaz-Solares M, Mim C, Dahl G, Barro-Soria R.   +5 more
europepmc   +2 more sources

DAMPs prognostic signature predicts tumor immunotherapy, and identifies immunosuppressive mechanism of pannexin 1 channels in pancreatic ductal adenocarcinoma. [PDF]

Front Immunol
Background Damage-associated molecular patterns (DAMPs) induced by immunogenic cell death (ICD) may be useful for the immunotherapy to patients undergoing pancreatic ductal adenocarcinoma (PDAC).
Wu Q, Xiao Q, Tang X, Li L, Song D, Zhou Y, Li B, Ren G, Luo F.   +8 more
europepmc   +2 more sources

Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation

Nature Communications, 2022
Pannexin-1 ion channels on endothelial cells regulate vascular inflammation and remodeling to mediate aortic aneurysm formation. Pharmacological blockade of Pannexin-1 channels may offer translational therapeutic mitigation of aneurysmal pathology.
Amanda C. Filiberto, Michael D. Spinosa, Craig T. Elder, Gang Su, Victoria Leroy, Zachary Ladd, Guanyi Lu, J. Hunter Mehaffey, Morgan D. Salmon, Robert B. Hawkins, Kodi S. Ravichandran, Brant E. Isakson, Gilbert R. Upchurch, Ashish K. Sharma   +13 more
doaj   +2 more sources

Pannexin 1 Influences Lineage Specification of Human iPSCs [PDF]

Frontiers in Cell and Developmental Biology, 2021
Every single cell in the body communicates with nearby cells to locally organize activities with their neighbors and dysfunctional cell-cell communication can be detrimental during cell lineage commitment, tissue patterning and organ development ...
Rebecca J. Noort, Grace A. Christopher, Jessica L. Esseltine   +2 more
doaj   +5 more sources

Connexin 43 and Pannexin 1 hemichannels as endogenous regulators of innate immunity in sepsis. [PDF]

Front Immunol
Sepsis is a life-threatening organ dysfunction resulting from a dysregulated host response to infections that is initiated by the body’s innate immune system. Nearly a decade ago, we discovered that bacterial lipopolysaccharide (LPS) and serum amyloid A (
Li J, Lou L, Chen W, Qiang X, Zhu C, Wang H.   +5 more
europepmc   +2 more sources