Results 21 to 30 of about 27,134,532 (169)

Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309. [PDF]

Elife
Protein phosphorylation is one of the major molecular mechanisms regulating protein activity and function throughout the cell. Pannexin 1 (PANX1) is a large-pore channel permeable to ATP and other cellular metabolites.
Ruan Z, Lee J, Li Y, Du J, Lü W.
europepmc   +2 more sources

Poly (I:C)-induced inflammation requires the activation of toll-like receptor 3/Ca²⁺/CaMKII/pannexin 1-dependent signaling. [PDF]

Theranostics
Pannexin1 (Panx1) is a glycoprotein, ubiquitously expressed throughout vertebrate tissues. In the cell membrane, it forms non-selective hemichannels (Panx1 HCs) that allow the release of ATP.
Salgado M, Sepúlveda-Arriagada V, Konar-Nié M, García-Robles MA, Sáez JC.   +4 more
europepmc   +2 more sources

Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity. [PDF]

J Physiol
Pannexin 1 (PANX1) is an ion and metabolite membrane channel and scaffold protein enriched in synaptic compartments of neurons in the central nervous system.
Casillas Martinez A, Wicki-Stordeur LE, Ariano AV, Swayne LA.   +3 more
europepmc   +2 more sources

Pannexin 1 induces Rhabdomyosarcoma cell fusion by downregulating APOBEC2 [PDF]

Oncogenesis
Rhabdomyosarcoma (RMS) is an aggressive cancer thought to arise from impaired myogenesis. This can be substantially overcome by increasing the levels of pannexin 1 (PANX1), a critical component of the myogenic program, but the mechanism involved is ...
Alexandra Welten, Amit Bera, Stéphanie Langlois, Xiao Xiang, Keshav Gupta, Emily Freeman, Kyle N. Cowan   +6 more
doaj   +2 more sources

Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry. [PDF]

Nat Commun
Opioid withdrawal is a liability of chronic opioid use and misuse, impacting people who use prescription or illicit opioids. Hyperactive autonomic output underlies many of the aversive withdrawal symptoms that make it difficult to discontinue chronic ...
Kwok CHT, Harding EK, Burma NE, Markovic T, Massaly N, van den Hoogen NJ, Stokes-Heck S, Gambeta E, Komarek K, Yoon HJ, Navis KE, McAllister BB, Canet-Pons J, Fan C, Dalgarno R, Gorobets E, Papatzimas JW, Zhang Z, Kohro Y, Anderson CL, Thompson RJ, Derksen DJ, Morón JA, Zamponi GW, Trang T.   +24 more
europepmc   +2 more sources

The C-terminal activating domain promotes pannexin 1 channel opening. [PDF]

Proc Natl Acad Sci U S A
Significance Signaling metabolites, such as adenosine triphosphate (ATP), are released through membrane channels to effectively clear dying cells in the body. Pannexin 1 (Panx1) serves as such a signal releaser and plays a pivotal role in immune response.
Henze E, Ehrlich JJ, Robertson JL, Gelsleichter E, Kawate T.   +4 more
europepmc   +2 more sources

Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice. [PDF]

Skelet Muscle
Background Duchenne muscular dystrophy (DMD) is associated with impaired muscle regeneration, progressive muscle weakness, damage, and wasting. While the cause of DMD is an X-linked loss of function mutation in the gene encoding dystrophin, the exact ...
Freeman E, Langlois S, Leyba MF, Ammar T, Léger Z, McMillan HJ, Renaud JM, Jasmin BJ, Cowan KN.   +8 more
europepmc   +2 more sources

The ATP-exporting channel Pannexin 1 promotes CD8⁺ T cell effector and memory responses. [PDF]

iScience
Summary Sensing of extracellular ATP (eATP) controls CD8+ T cell function. Their accumulation can occur through export by specialized molecules, such as the release channel Pannexin 1 (Panx1).
Vardam-Kaur T, Banuelos A, Gabaldon-Parish M, Macedo BG, Salgado CL, Wanhainen KM, Zhou MH, van Dijk S, Santiago-Carvalho I, Beniwal AS, Leff CL, Peng C, Tran NL, Jameson SC, Borges da Silva H.   +14 more
europepmc   +2 more sources

Pannexin-1 opening in neuronal edema causes cell death but also leads to protection via increased microglia contacts. [PDF]

Cell Rep, 2023
Neuronal swelling during cytotoxic edema is triggered by Na+ and Cl- entry and is Ca2+ independent. However, the causes of neuronal death during swelling are unknown.
Weilinger NL, Yang K, Choi HB, Groten CJ, Wendt S, Murugan M, Wicki-Stordeur LE, Bernier LP, Velayudhan PS, Zheng J, LeDue JM, Rungta RL, Tyson JR, Snutch TP, Wu LJ, MacVicar BA.   +15 more
europepmc   +2 more sources

The Role of Pannexin-1 Channels in HIV and NeuroHIV Pathogenesis [PDF]

Cells, 2022
The human immunodeficiency virus-1 (HIV) enters the brain shortly after infection, leading to long-term neurological complications in half of the HIV-infected population, even in the current anti-retroviral therapy (ART) era. Despite decades of research,
Cristian A. Hernandez, Eugenin Eliseo
doaj   +2 more sources