Results 81 to 90 of about 27,134,532 (169)
Journal of Neurochemistry, Volume 170, Issue 3, March 2026.Low/brief glucocorticoid (GC) elevations can enhance mitochondrial output (↑ oxygen consumption rate, OCR; ↑ mitochondrial membrane potential, ΔΨm) and Ca2+ buffering, in part via glucocorticoid receptor (GR) trafficking to mitochondria in complexes with Bcl2 and Bag1.
Paweł Hanus +2 more
wiley +1 more source
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2020 Introduction: Diabetes is one of the most common metabolic diseases that is associated with high blood sugar and can cause disorders of the central nervous system.
Mohammad Rami +3 more
doaj
Pannexin 1 inhibition delays maturation and improves development of Bos taurus oocytes
Journal of Ovarian Research, 2020 Background Intercellular exchange between the oocyte and its surrounding cells within the follicular environment is critical for oocyte maturation and subsequent development.
Zachary Timothy Dye +3 more
doaj +1 more source
Experimental Physiology, Volume 111, Issue 3, Page 1524-1542, 1 March 2026.Abstract Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G‐protein‐coupled receptors and G12/RhoA/Rho kinase are implicated in myogenic tone (MT), and we aimed to clarify their role in pressure sensing and ...
Gry Freja Skovsted +11 more
wiley +1 more source
Pannexin 1 in erythrocytes: Function without a gap [PDF]
Proceedings of the National Academy of Sciences, 2006 ATP is a widely used extracellular signaling molecule. The mechanism of ATP release from cells is presently unresolved and may be either vesicular or channel-mediated. Erythrocytes release ATP in response to low oxygen or to shear stress. In the absence of vesicles, the release has to be through channels. Erythrocytes do not form gap junctions.
Silviu, Locovei, Li, Bao, Gerhard, Dahl
openaire +2 more sources
Frontiers in Cellular Neuroscience, 2020 Synaptic loss induced by soluble oligomeric forms of the amyloid β peptide (sAβos) is one of the earliest events in Alzheimer’s disease (AD) and is thought to be the major cause of the cognitive deficits.
Carolina Flores-Muñoz +25 more
doaj +1 more source
Neurobiology of Disease, 2021 Human immunodeficiency virus-1 (HIV-1) has been shown to cross the blood-brain barrier and cause HIV-associated neurocognitive disorders (HAND) through a process that may involve direct or indirect interactions with the central nervous system (CNS) cells
Hyung Joon Cho +4 more
doaj +1 more source
The ATP-exporting channel Pannexin-1 promotes CD8+ T cell effector and memory responses
bioRxiv, 2023 Sensing of extracellular ATP (eATP) controls CD8+ T cell function. Their accumulation can occur through export by specialized molecules, such as the release channel Pannexin-1 (Panx1). Whether Panx1 controls CD8+ T cell immune responses in vivo, however,
Trupti Vardam-Kaur +14 more
semanticscholar +1 more source
Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley +1 more source
Emerging concepts regarding pannexin 1 in the vasculature [PDF]
Biochemical Society Transactions, 2015 Pannexin channels are newly discovered ATP release channels expressed throughout the body. Pannexin 1 (Panx1) channels have become of great interest as they appear to participate in a multitude of signalling cascades, including regulation of vascular function. Although numerous Panx1 pharmacological inhibitors have been discovered, these inhibitors are
Miranda E, Good +5 more
openaire +2 more sources