Results 141 to 150 of about 1,563 (163)
Some of the next articles are maybe not open access.
2009
Pannexins are a family of three vertebrate proteins that have moderate sequence homology with the innexin proteins, which compose gap junction channels in protostomes, including most invertebrates. However, it appears that in contrast to innexins, pannexins do not have the ability to form gap junction channels.
Gerhard Dahl, Andrew L. Harris
openaire +1 more source
Pannexins are a family of three vertebrate proteins that have moderate sequence homology with the innexin proteins, which compose gap junction channels in protostomes, including most invertebrates. However, it appears that in contrast to innexins, pannexins do not have the ability to form gap junction channels.
Gerhard Dahl, Andrew L. Harris
openaire +1 more source
Connexins and Pannexins in Vascular Function and Disease [PDF]
International Journal of Molecular Sciences, 2018 Connexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming proteins that are critically involved in many aspects of vascular physiology and pathology. The permeation of ions and small metabolites through Panx channels, Cx hemichannels and gap junction channels confers a crucial role to these proteins in intercellular communication ...
Xavier Figueroa +2 more
exaly +5 more sources
Connexins and pannexins in Alzheimer’s disease
Neuroscience Letters, 2019By 2040 neurodegenerative diseases will become the world's second leading cause of death after cardiovascular disease (WHO). Major efforts are required to elucidate the underlying molecular and cellular mechanisms of neurodegenerative diseases. Connexin and pannexin membrane channel proteins are conduits through which neuronal, glial, and vascular ...
Christian, Giaume +4 more
openaire +3 more sources
Ubiquitination and Proteasomal Regulation of Pannexin 1 and Pannexin 3
2020Pannexin 1 (PANX1) and Pannexin 3 (PANX3) are single-membrane channel glycoproteins that allow for communication between the cell and its environment to regulate cellular differentiation, proliferation, and apoptosis. Their expression is regulated through post-translational modifications, however, their regulation by ubiquitination and the ubiquitin ...
openaire +2 more sources
Pannexin-1 channels in epilepsy
Neuroscience Letters, 2019Pannexin-1 (Panx1) expression is raised in several animal seizure models and in resected human epileptic brain tissue, suggesting relevance to epilepsy. Multiple factors that are characteristic of seizures are thought to regulate Panx1 channel opening, including elevated levels of extracellular K+.
Mark S, Aquilino +3 more
openaire +2 more sources
Pannexin: To gap or not to gap, is that a question?
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 2006Vertebrates express two families of gap junction proteins: the well characterized connexins and the recently discovered pannexins. The latter are related to invertebrate innexins. Here we present the hypothesis that pannexins, rather than providing a redundant system to gap junctions formed by connexins, exert a physiological role as nonjunctional ...
Gerhard, Dahl, Silviu, Locovei
openaire +2 more sources
Connexin-Pannexin duality in glioblastoma
Cell and Tissue ResearchGlioblastoma (GBM) is the most aggressive primary brain tumour in adults, characterized by extensive heterogeneity and diffuse invasion. Increasing evidence highlights the role of channel-forming proteins in glioma biology. Connexins (Cxs) and Pannexins (Panxs) are two structurally related yet functionally distinct protein families that mediate ...
Rehanna, Kanji +2 more
openaire +2 more sources
2022
Die hypoxische pulmonale Vasokonstriktion ist ein durch alveoläre Hypoxie ausgelöster aktiver physiologischer Mechanismus, der den pulmonalen Blutfluss aus sauerstoffärmeren Bereichen der Lunge in besser ventilierte Regionen umleitet, um die Sauerstoffversorgung zu optimieren. Die molekularen Signalwege, welche die hypoxische pulmonale Vasokonstriktion
openaire +1 more source
Die hypoxische pulmonale Vasokonstriktion ist ein durch alveoläre Hypoxie ausgelöster aktiver physiologischer Mechanismus, der den pulmonalen Blutfluss aus sauerstoffärmeren Bereichen der Lunge in besser ventilierte Regionen umleitet, um die Sauerstoffversorgung zu optimieren. Die molekularen Signalwege, welche die hypoxische pulmonale Vasokonstriktion
openaire +1 more source
Peptide-based targeting of connexins and pannexins for therapeutic purposes
Expert Opinion on Drug Discovery, 2020Mathieu Vinken +2 more
exaly