Results 171 to 180 of about 1,892 (187)

Connexins, innexins and pannexins: Bridging the communication gap

Biochimica Et Biophysica Acta - Biomembranes, 2005
Multicellular organisms have evolved different mechanisms of intercellular communication, the most direct and quickest of which is through channels that link the cytoplasms of adjacent cells.
Jean-Claude Hervé, Pauline Phelan, Roberto Bruzzone   +2 more
exaly   +2 more sources

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Connexins and pannexins in Alzheimer’s disease

Neuroscience Letters, 2019
By 2040 neurodegenerative diseases will become the world's second leading cause of death after cardiovascular disease (WHO). Major efforts are required to elucidate the underlying molecular and cellular mechanisms of neurodegenerative diseases. Connexin and pannexin membrane channel proteins are conduits through which neuronal, glial, and vascular ...
Christian, Giaume, Juan C, Sáez, Weihong, Song, Luc, Leybaert, Christian C, Naus   +4 more
openaire   +3 more sources

Ubiquitination and Proteasomal Regulation of Pannexin 1 and Pannexin 3

2020
Pannexin 1 (PANX1) and Pannexin 3 (PANX3) are single-membrane channel glycoproteins that allow for communication between the cell and its environment to regulate cellular differentiation, proliferation, and apoptosis. Their expression is regulated through post-translational modifications, however, their regulation by ubiquitination and the ubiquitin ...
openaire   +2 more sources

Pannexins or Connexins?

2009
Pannexins are a family of three vertebrate proteins that have moderate sequence homology with the innexin proteins, which compose gap junction channels in protostomes, including most invertebrates. However, it appears that in contrast to innexins, pannexins do not have the ability to form gap junction channels.
Gerhard Dahl, Andrew L. Harris
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Pannexin-1 channels in epilepsy

Neuroscience Letters, 2019
Pannexin-1 (Panx1) expression is raised in several animal seizure models and in resected human epileptic brain tissue, suggesting relevance to epilepsy. Multiple factors that are characteristic of seizures are thought to regulate Panx1 channel opening, including elevated levels of extracellular K+.
Mark S, Aquilino, Paige, Whyte-Fagundes, Georg, Zoidl, Peter L, Carlen   +3 more
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Connexin-Pannexin duality in glioblastoma

Cell and Tissue Research
Glioblastoma (GBM) is the most aggressive primary brain tumour in adults, characterized by extensive heterogeneity and diffuse invasion. Increasing evidence highlights the role of channel-forming proteins in glioma biology. Connexins (Cxs) and Pannexins (Panxs) are two structurally related yet functionally distinct protein families that mediate ...
Rehanna, Kanji, Silvia, Penuela, Marc, Mesnil   +2 more
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Pannexin 1

2022
Die hypoxische pulmonale Vasokonstriktion ist ein durch alveoläre Hypoxie ausgelöster aktiver physiologischer Mechanismus, der den pulmonalen Blutfluss aus sauerstoffärmeren Bereichen der Lunge in besser ventilierte Regionen umleitet, um die Sauerstoffversorgung zu optimieren. Die molekularen Signalwege, welche die hypoxische pulmonale Vasokonstriktion
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Peptide-based targeting of connexins and pannexins for therapeutic purposes

Expert Opinion on Drug Discovery, 2020
Anne Caufriez, Charlotte Martin, Steven Ballet   +2 more
exaly  

Pannexins

2012
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Dispelling myths about connexins, pannexins and P2X7 in hypoxic-ischemic central nervous system

Neuroscience Letters, 2019
Natiele Carla da Silva Ferreira, Luiz Anastacio Alves, Renato Rozental   +2 more
exaly