Results 1 to 10 of about 2,639 (160)
Loss of Panx1 Impairs Mammary Gland Development at Lactation: Implications for Breast Tumorigenesis. [PDF]
PLoS ONE, 2016 Pannexin1 (Panx1) subunits oligomerize to form large-pore channels between the intracellular and extracellular milieu that have been shown to regulate proliferation, differentiation and cell death mechanisms.
Michael K G Stewart +3 more
doaj +6 more sources
A metastasis-associated pannexin-1 mutant (Panx1<sup>1-89</sup>) forms a minimalist ATP release channel. [PDF]
FEBS JA truncation mutant of Panx1 (Panx11‐89), enriched in metastatic breast cancer cells, is capable of forming a large ATP‐permeable membrane channel despite containing only 20% of the amino‐terminal amino acids of the wild‐type channel protein (wtPanx1). However, cells expressing Panx11‐89 alone die, whereas co‐expression of wtPanx1 is protective.
Wang J +5 more
europepmc +2 more sources
The Contribution of Astrocyte and Neuronal Panx1 to Seizures Is Model and Brain Region Dependent
ASN Neuro, 2021 Pannexin1 (Panx1) is an ATP release channel expressed in neurons and astrocytes that plays important roles in CNS physiology and pathology. Evidence for the involvement of Panx1 in seizures includes the reduction of epileptiform activity and ictal ...
Price Obot +3 more
doaj +1 more source
Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury. [PDF]
PLoS ONE, 2012 Pannexin1 (Panx1) forms large nonselective membrane channel that is implicated in paracrine and inflammatory signaling. In vitro experiments suggested that Panx1 could play a key role in ischemic death of hippocampal neurons. Since retinal ganglion cells
Galina Dvoriantchikova +6 more
doaj +1 more source
Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice
eLife, 2021 Pannexin 1 (Panx1), an ATP-efflux pathway, has been linked with inflammation in pulmonary capillaries. However, the physiological roles of endothelial Panx1 in the pulmonary vasculature are unknown.
Zdravka Daneva +10 more
doaj +1 more source
Journal of Neuroinflammation, 2020 Background Neuroinflammation is a major component of secondary damage after traumatic brain injury (TBI). We recently reported that pharmacological inhibition of Pannexin-1 (Panx1) channels markedly reduced the inflammatory response after TBI.
Joon Ho Seo +3 more
doaj +1 more source
Stomatin inhibits pannexin-1-mediated whole-cell currents by interacting with its carboxyl terminal. [PDF]
PLoS ONE, 2012 The pannexin-1 (Panx1) channel (often referred to as the Panx1 hemichannel) is a large-conductance channel in the plasma membrane of many mammalian cells.
Haiying Zhan +9 more
doaj +1 more source
Pannexin-1 Contributes to the Apoptosis of Spinal Neurocytes in Spinal Cord Injury
Frontiers in Physiology, 2021 Currently, the role of Pannexin-1, a homomeric membrane hemichannel on the neuron cell membrane, in the development of spinal cord injury (SCI) is largely unknown. Herein, we assessed the contribution of Panx1 in the development of SCI.
Yu Huang +3 more
doaj +1 more source
Oncogenesis, 2022 Rhabdomyosarcoma (RMS) is a deadly cancer of skeletal muscle origin. Pannexin 1 (PANX1) is down-regulated in RMS and increasing its levels drastically inhibits RMS progression.
Xiao Xiang +5 more
doaj +1 more source
Pannexin 1 Influences Lineage Specification of Human iPSCs
Frontiers in Cell and Developmental Biology, 2021 Every single cell in the body communicates with nearby cells to locally organize activities with their neighbors and dysfunctional cell-cell communication can be detrimental during cell lineage commitment, tissue patterning and organ development ...
Rebecca J. Noort +2 more
doaj +1 more source