Results 91 to 100 of about 2,639 (160)

A novel heterozygous missense variant of PANX1 causes human oocyte death and female infertility

Journal of Ovarian Research
Pannexin1 (PANX1) is a highly glycosylated membrane channel-forming protein, which has been found to implicate in multiple physiological and pathophysiological functions.
Juepu Zhou, Ruolin Mao, Meng Wang, Rui Long, Limin Gao, Xiangfei Wang, Lei Jin, Lixia Zhu   +7 more
doaj   +1 more source

Microglial Panx1 is a Spinal Determinant of Arthritis Joint Pain

, 2018
Pain is a debilitating feature of arthritis. Despite recent advances in treating joint inflammation and the widespread use of pain medications by arthritis patients, adequate pain control is an ongoing medical problem. A major challenge is that joint pain is poorly understood: some individuals with severe joint damage report little pain, whereas ...
openaire   +2 more sources

Activation of Pannexin-1 channels causes cell dysfunction and damage in mesangial cells derived from angiotensin II-exposed mice

Frontiers in Cell and Developmental Biology
Chronic kidney disease (CKD) is a prevalent health concern associated with various pathological conditions, including hypertensive nephropathy. Mesangial cells are crucial in maintaining glomerular function, yet their involvement in CKD pathogenesis ...
Claudia M. Lucero, Laura Navarro, Cristián Barros-Osorio, Patricio Cáceres-Conejeros, Juan A. Orellana, Gonzalo I. Gómez   +5 more
doaj   +1 more source

Pannexin 1 (PANX1) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage

Biological Research
Abstract Background Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that non-voluntary alcohol consumption increases the opening of Cx43 hemichannels and Panx1 ...
Gonzalo I. Gómez, Tanhia F. Alvear, Daniela A. Roa, Arantza Farias-Pasten, Sergio A. Vergara, Luis A. Mellado, Claudio J. Martinez-Araya, Juan Prieto-Villalobos, Claudia García-Rodríguez, Natalia Sánchez, Juan C. Sáez, Fernando C. Ortíz, Juan A. Orellana   +12 more
openaire   +4 more sources

NMDAR-mediated activation of pannexin1 channels contributes to the detonator properties of hippocampal mossy fiber synapses

iScience
Summary: Pannexins are large-pore ion channels expressed throughout the mammalian brain that participate in various neuropathologies; however, their physiological roles remain obscure.
Cinthia Rangel-Sandoval, Marisol Soula, Wei-Ping Li, Pablo E. Castillo, David L. Hunt   +4 more
doaj   +1 more source

Cardiovascular Characterization of Cx40/Panx1 Single and Double Knockout Mice [PDF]

, 2016
Connexins (Cxs) and pannexins (Panxs) are protein families that form large-pore channels which exist at the plasma membrane for both intracellular and extracellular signaling. Given their potential for overlapping cellular signaling functions we proposed that mice lacking both a connexin and a pannexin would have a severe phenotype. To investigate this
openaire  

Pannexins in the heart: cell-specific expression and contributions to disease. [PDF]

Cell Tissue Res
Renton MC, Sedovy MW, Reynolds A, Hoch A, Roberts K, Sarmiento R, Toler C, Johnstone SR.   +7 more
europepmc   +1 more source

Pannexin-1 is present in a subpopulation of bovine milk-derived small extracellular vesicles. [PDF]

Cell Tissue Res
Amin MR, Marsh SR, Beard C, Payne LB, Charest A, Stout RF, Gourdie RG.   +6 more
europepmc   +1 more source

ATP increases murine neuroblastoma cell size through a PANX1- and macropinocytosis-dependent mechanism. [PDF]

Biol Open
Boyce AKJ, You H, Wicki-Stordeur LE, Swayne LA.   +3 more
europepmc   +1 more source