Results 11 to 20 of about 2,639 (160)
Mouse Panx1 Is Dispensable for Hearing Acquisition and Auditory Function [PDF]
Frontiers in Molecular Neuroscience, 2017 Panx1 forms plasma membrane channels in brain and several other organs, including the inner ear. Biophysical properties, activation mechanisms and modulators of Panx1 channels have been characterized in detail, however the impact of Panx1 on auditory ...
Veronica Zorzi +23 more
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Investigation of olfactory function in a Panx1 knock out mouse model [PDF]
Frontiers in Cellular Neuroscience, 2014 Pannexin 1 (Panx1), the most extensively investigated member of a channel-forming protein family, is able to form pores conducting molecules up to 1.5 kDa, like ATP, upon activation.
Stefan eKurtenbach +7 more
doaj +3 more sources
Astrocyte and Neuronal Panx1 Support Long-Term Reference Memory in Mice
ASN Neuro, 2023 Pannexin 1 (Panx1) is an ubiquitously expressed protein that forms plasma membrane channels permeable to anions and moderate-sized signaling molecules (e.g., ATP, glutamate).
Price Obot +7 more
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Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain
Military Medical ResearchBackground The channel-forming protein Pannexin1 (Panx1) has been implicated in both human studies and animal models of chronic pain, but the underlying mechanisms remain incompletely understood.
Qu Xing +7 more
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Apically localized PANX1 impacts neuroepithelial expansion in human cerebral organoids
Cell Death DiscoveryDysfunctional paracrine signaling through Pannexin 1 (PANX1) channels is linked to several adult neurological pathologies and emerging evidence suggests that PANX1 plays an important role in human brain development.
Rebecca J. Noort +5 more
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Military Medical ResearchBackground Extracellular adenosine triphosphate (ATP) is an important signal molecule. In previous studies, intensive research had revealed the crucial roles of family with sequence similarity 3 member A (FAM3A) in controlling hepatic glucolipid ...
Cheng-Qing Hu +14 more
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Cationic control of Panx1 channel function [PDF]
American Journal of Physiology-Cell Physiology, 2018 The sequence and predicted membrane topology of pannexin1 (Panx1) places it in the family of gap junction proteins. However, rather than forming gap junction channels, Panx1 forms channels in the nonjunctional membrane. Panx1 operates in two distinct open states, depending on the mode of stimulation.
Junjie, Wang +2 more
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Cx43 Hemichannel and Panx1 Channel Modulation by Gap19 and 10Panx1 Peptides
International Journal of Molecular Sciences, 2023 Cx43 hemichannels (HCs) and Panx1 channels are two genetically distant protein families. Despite the lack of sequence homology, Cx43 and Panx1 channels have been the subject of debate due to their overlapping expression and the fact that both channels present similarities in terms of their membrane topology and electrical properties.
Alessio Lissoni +4 more
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Panx1 promotes invasion-metastasis cascade in hepatocellular carcinoma [PDF]
Journal of Cancer, 2019 Background: The molecular function of pannexin1 (Panx1) in different tumor types has been remained equivocal. Until now, there is no study focused on the function of panx1 in hepatocellular carcinoma (HCC). This study aimed to explore the role of Panx1 in the invasion and metastasis of HCC.
Shi, Guangjun +8 more
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SCAM analysis of Panx1 suggests a peculiar pore structure [PDF]
Journal of General Physiology, 2010 Vertebrates express two families of gap junction proteins: the well-characterized connexins and the pannexins. In contrast to connexins, pannexins do not appear to form gap junction channels but instead function as unpaired membrane channels. Pannexins have no sequence homology to connexins but are distantly related to the invertebrate gap junction ...
Wang, Junjie, Dahl, Gerhard
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