Results 21 to 30 of about 2,639 (160)
Differential activation of mouse and human Panx1 channel variants
PLOS ONE, 2023 Pannexins are ubiquitously expressed in human and mouse tissues. Pannexin 1 (Panx1), the most thoroughly characterized member of this family, forms plasmalemmal membrane channels permeable to relatively large molecules, such as ATP.
Antonio Cibelli +3 more
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Normal Taste Acceptance and Preference of PANX1 Knockout Mice [PDF]
Chemical Senses, 2015 Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1).
Michael G, Tordoff +8 more
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Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles [PDF]
International Journal of Molecular Sciences, 2022 Pannexins (PANX) were cloned based on their sequence homology to innexins (Inx), invertebrate gap junction proteins. Although there is no sequence homology between PANX and connexins (Cx), these proteins exhibit similar configurations. The PANX family has three members, PANX1, PANX2 and PANX3.
Yang, Kai +5 more
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Biomedicines, 2022 Pannexins are transmembrane glycoproteins that constitute channels involved in purinergic signaling through ATP release from cells in various physiological and pathological processes.
Ivo Jeličić +6 more
doaj +1 more source
Pannexin-1 Modulates Inhibitory Transmission and Hippocampal Synaptic Plasticity
Biomolecules, 2023 Pannexin-1 (Panx1) hemichannel is a non-selective transmembrane channel that may play important roles in intercellular signaling by allowing the permeation of ions and metabolites, such as ATP. Although recent evidence shows that the Panx1 hemichannel is
Francisca García-Rojas +6 more
doaj +1 more source
Adaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels
Molecular Metabolism, 2021 Objective: Brown adipose tissue (BAT) is specialized in thermogenesis. The conversion of energy into heat in brown adipocytes proceeds via stimulation of β-adrenergic receptor (βAR)-dependent signaling and activation of mitochondrial uncoupling protein 1
Subramanian Senthivinayagam +20 more
doaj +1 more source
Inhibition of the P2X7–PANX1 complex suppresses spreading depolarization and neuroinflammation [PDF]
Brain, 2017 Abstract Spreading depolarization is a wave of neuronal and glial depolarization. Within minutes after spreading depolarization, the neuronal hemichannel pannexin 1 (PANX1) opens and forms a pore complex with the ligand-gated cation channel P2X7, allowing the release of excitatory neurotransmitters to sustain spreading depolarization ...
Chen, S.P. +9 more
openaire +3 more sources
Pannexin 1 channels in skeletal muscles
Frontiers in Physiology, 2014 Normal myotubes and adult innervated skeletal myofibers express the glycoprotein pannexin1 (Panx1). Six of them form a gap junction hemichannel-like structure that connects the cytoplasm with the extracellular space; here they will be called Panx1 ...
Luis Andrés Cea +6 more
doaj +1 more source
Cells, 2022 Pannexin1 (Panx1) is expressed in both neurons and glia where it forms ATP-permeable channels that are activated under pathological conditions such as epilepsy, migraine, inflammation, and ischemia.
Antonio Cibelli +2 more
doaj +1 more source
Cells, 2022 Enhanced activity and overexpression of Pannexin 1 (Panx1) channels contribute to neuronal pathologies such as epilepsy and Alzheimer’s disease (AD). The Panx1 channel ablation alters the hippocampus’s glutamatergic neurotransmission, synaptic plasticity,
Carolina Flores-Muñoz +11 more
doaj +1 more source