Results 31 to 40 of about 2,639 (160)
Cell Reports, 2023 Summary: Neuronal swelling during cytotoxic edema is triggered by Na+ and Cl− entry and is Ca2+ independent. However, the causes of neuronal death during swelling are unknown. Here, we investigate the role of large-conductance Pannexin-1 (Panx1) channels
Nicholas L. Weilinger +15 more
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PANX1 hexamers work but cells prefer heptamers. [PDF]
J Gen PhysiolGupta et al. (https://doi.org/10.1085/jgp.202413676) reconcile a disconnect between structural and functional data regarding stoichiometry of PANX1 channels and provide new insights about channel activation.
Harris AL.
europepmc +3 more sources
Selective inhibition of Panx1 channels decreases hemostasis and thrombosis in vivo [PDF]
Thrombosis Research, 2019 Hemostasis is a tightly regulated physiological process to rapidly induce hemostatic plugs at sites of vascular injury. Inappropriate activation of this process may lead to thrombosis, i.e. pathological blood clot formation in uninjured vessels or on atherosclerotic lesions.
Molica, Filippo +9 more
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Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling [PDF]
, 2021 AbstractMicroglia are brain-resident immune cells with a repertoire of functions in the developing, mature and pathological brain. Their wide-ranging roles in physiology include the clearance of cellular debris, elimination of excess synapses, regulation of neuronal activity and contributions to blood vessel development.
Kanchan Bisht +18 more
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Frontiers in Immunology, 2023 Sepsis represents a global health concern, and patients with severe sepsis are at risk of experiencing MODS (multiple organ dysfunction syndrome), which is associated with elevated mortality rates and a poorer prognosis.
Xiangyu Chen +4 more
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Contribution of pannexin1 to experimental autoimmune encephalomyelitis. [PDF]
PLoS ONE, 2013 Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. We tested the hypothesis that
Sarah E Lutz +10 more
doaj +1 more source
Pannexin1 channels—a potential therapeutic target in inflammation
Frontiers in Cell and Developmental Biology, 2022 An exaggerated inflammatory response is the hallmark of a plethora of disorders. ATP is a central signaling molecule that orchestrates the initiation and resolution of the inflammatory response by enhancing activation of the inflammasome, leukocyte ...
Olga M. Rusiecka +7 more
doaj +1 more source
PANX1- Immunosuppressive tumor microenvironment (TME)
, 2021 Research Data for PANX1- Immunosuppressive tumor microenvironment (TME ...
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Intracellular Cysteine 346 Is Essentially Involved in Regulating Panx1 Channel Activity [PDF]
Journal of Biological Chemistry, 2010 Pannexins constitute a family of proteins exhibiting predominantly hemichannel activity. Pannexin channels have been suggested to participate in a wide spectrum of biological functions such as propagation of calcium waves, release of IL-1β, and responses to ischemic conditions.
Stefanie, Bunse +4 more
openaire +2 more sources
Powerful partnership: crosstalk between pannexin 1 and the cytoskeleton
Frontiers in Physiology, 2014 Pannexin 1 (Panx1) large-pore ion and metabolite channels are emerging as key proteins in many physiological and pathophysiological scenarios. Recent evidence has tightly linked Panx1 trafficking and function to the cytoskeleton, a multi-component ...
Andrew Kenneth Jameson Boyce +5 more
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