Results 41 to 50 of about 2,639 (160)
Molecular pathways of pannexin1-mediated neurotoxicity
Frontiers in Physiology, 2014 Pannexin1 (Panx1) forms nonselective membrane channels, structurally similar to gap junction hemichannels, that is permeable to ions, nucleotides and other small molecules below 900 Da. Panx1 activity is implicated in paracrine signaling and inflammasome
Valery I. Shestopalov +4 more
doaj +1 more source
ATP triggers macropinocytosis that internalizes and is regulated by PANX1 [PDF]
, 2020 ABSTRACTMacropinocytosis is an endocytic process that allows cells to respond to changes in their environment by internalizing nutrients and cell surface proteins, as well as modulating cell size. Here, we identify that adenosine triphosphate (ATP) triggers macropinocytosis in murine neuroblastoma cells, thereby internalizing the ATP release channel ...
Andrew K.J. Boyce +3 more
openaire +1 more source
A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model
Frontiers in Molecular Neuroscience, 2018 Pannexins (Panx) are integral membrane proteins, with Panx1 being the best-characterized member of the protein family. Panx1 is implicated in sensory processing, and knockout (KO) animal models have become the primary tool to investigate the role(s) of ...
Paige Whyte-Fagundes +10 more
doaj +1 more source
The Ant1 / panx1 pathway sensitizes patients with NAFLD to lifestyle interventions [PDF]
, 2022 Abstract Background: Different patients have different sensitivities to lifestyle interventions (LSI) and thus different outcomes (improved or unchanged). In the present study, we aim to find key markers that can identify patients sensitive to lifestyle interventions.
Bo Sun +3 more
openaire +1 more source
Prothrombotic Activation of Platelet Pannexin‐1 Channels in Antiphospholipid Syndrome
Arthritis &Rheumatology, EarlyView.Objective ATP is released from platelets through both degranulation and pannexin‐1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium‐dependent signaling. The objective of this study was to evaluate the role of platelet PANX1 channels in the pathophysiology of antiphospholipid syndrome (APS), an acquired ...
Bruna de Moraes Mazetto Fonseca +13 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li +4 more
wiley +1 more source
Promises and pitfalls of a Pannexin1 transgenic mouse line.
Frontiers in Pharmacology, 2013 Gene targeting strategies have become a powerful technology for elucidating mammalian gene function. The recently generated knockout (KO)-first strategy produces a knockout at the RNA processing level and also allows for the generation of conditional KO ...
Regina eHanstein +7 more
doaj +1 more source
Cancer Science, EarlyView.Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda +2 more
wiley +1 more source
Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.1. Astrocytes are central integrators of neural circuit function through tripartite synapse modulation and neurovascular coupling. 2. Dysregulation of glutamate/GABA homeostasis and neuroinflammation represents shared mechanisms across diverse neuropsychiatric disorders. 3.
Xinyu Liu +10 more
wiley +1 more source
Inhibition of PANX1 Channels Reduces the Malignant Properties of Human High-Risk Neuroblastoma
Journal of Cancer, 2023 Pannexin 1 (PANX1) is expressed in many tissue types including tissues of neural origin. Neuroblastoma (NB) is a neural crest-derived malignancy mainly occurring in children. The majority of NB patients present with high-risk disease for which current therapies are ineffective. Here, we show that while PANX1 is expressed in NB of all stages, high PANX1
Langlois, Stéphanie +10 more
openaire +2 more sources