Results 61 to 70 of about 2,639 (160)

Pannexin 1 dysregulation in Duchenne muscular dystrophy and its exacerbation of dystrophic features in mdx mice

Skeletal Muscle
Background Duchenne muscular dystrophy (DMD) is associated with impaired muscle regeneration, progressive muscle weakness, damage, and wasting. While the cause of DMD is an X-linked loss of function mutation in the gene encoding dystrophin, the exact ...
Emily Freeman, Stéphanie Langlois, Marcos F. Leyba, Tarek Ammar, Zacharie Léger, Hugh J. McMillan, Jean-Marc Renaud, Bernard J. Jasmin, Kyle N. Cowan   +8 more
doaj   +1 more source

Blocking Pannexin 1 Channels Alleviates Peripheral Inflammatory Pain but not Paclitaxel-Induced Neuropathy

Journal of Integrative Neuroscience
Background: Pannexin1 (Panx1) is a membrane channel expressed in different cells of the nervous system and is involved in several pathological conditions, including pain and inflammation.
Julia Borges Paes Lemes, Kaue Franco Malange, Nathalia Santos Carvalho, Amanda Ferreira Neves, Marcia Urban-Maldonado, Paula Regina Gelinski Kempe, Catarine Massucato Nishijima, Cecilia Costa Fagundes, Celina Monteiro da Cruz Lotufo, Sylvia Ottile Suadicani, Carlos Amilcar Parada   +10 more
doaj   +1 more source

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Cell Proliferation, Volume 58, Issue 10, October 2025.
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen, Haijun Zhang, Zhaoheng Wang, Daxue Zhu, Yanhu Li, Yizhi Zhang, Dongxin Wang, Shuwei Chen, Huan Liu, Xuewen Kang   +9 more
wiley   +1 more source

Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

MedComm, Volume 6, Issue 9, September 2025.
Ferroptosis, a form of cell death driven by iron and lipid peroxidation, serves as a bridge between cancer and inflammatory diseases. Microenvironmental factors such as oxidative stress collectively regulate this process. In cancer, ferroptosis exhibits dual roles: while it eliminates drug‐resistant cells, it may also promote tumor metastasis.
Guangyi Shen, Jiachen Liu, Yinhuai Wang, Zebin Deng, Fei Deng   +4 more
wiley   +1 more source

Cardiomyocyte PANX1 Controls Glycolysis and Neutrophil Recruitment in Hypertrophy

Circulation Research
BACKGROUND: PANX1 (pannexin 1), a ubiquitously expressed ATP release membrane channel, has been shown to play a role in inflammation, blood pressure regulation, and myocardial infarction. However, the possible role of PANX1 in cardiomyocytes in the progression of heart failure has not yet been investigated.
Caitlin M. Pavelec, Alexander P. Young, Hannah L. Luviano, Emily E. Orrell, Anna Szagdaj, Nabin Poudel, Abigail G. Wolpe, Samantha H. Thomas, Scott Yeudall, Clint M. Upchurch, Mark D. Okusa, Brant E. Isakson, Matthew J. Wolf, Norbert Leitinger   +13 more
openaire   +2 more sources

Analysis of P2X7 Receptor and Panx1 Expression in Osteoporosis

, 2019
Objectives: Osteoporosis, characterized by bone mineral density decrease, leads to a high risk of bone fracture. It is now widely recognized that purinergic signaling plays an important role in the regulation of bone remodeling [ref:1]. One receptor subtype, P2X receptor is considered to be[for full text, please go to the a.m. URL]
Tang, M, Kauschke, V, El Khassawna, T, Heiß, C, Lips, K   +4 more
openaire   +2 more sources

Pannexin 1 channels: new actors in the regulation of catecholamine release from adrenal chromaffin cells

Frontiers in Cellular Neuroscience, 2014
Chromaffin cells of the adrenal gland medulla synthesize and store hormones and peptides, which are released into the blood circulation in response to stress. Among them, adrenaline is critical for the fight-or-flight response.
Fanny eMomboisse, María José Olivares, Ximena eBáez-Matus, María José Guerra, Carolina eFlores-Muñoz, Juan C. Sáez, Agustin D. Martinez, Ana M. Cárdenas   +7 more
doaj   +1 more source

Mitochondrial Quality Control in Health and Disease

MedComm, Volume 6, Issue 8, August 2025.
Mitochondrial quality control (MQC) maintains cellular homeostasis by coordinating various processes such as fission, fusion, mitophagy, and mitochondria‐regulated cell death. Dysregulation of these mechanisms plays a key role in the development of many human diseases.
Lin Ye, Xinzhi Fu, Qi Li
wiley   +1 more source

The role of reactive enteric glia‐macrophage interactions in acute and chronic inflammation

Neurogastroenterology &Motility, Volume 37, Issue 8, August 2025.
Abstract Enteric glia are a heterogeneous population of peripheral glia within the enteric nervous system and play pivotal roles in gut homeostasis, tissue integrity, coordination of motility, and intestinal immune responses. Under physiological conditions, they communicate with enteric neurons to control intestinal motility.
Schneider Reiner, Schneider Linda, Hamza Ebrahim, Leven Patrick, Wehner Sven   +4 more
wiley   +1 more source

Astrocyte and Neuronal Pannexin1 Contribute Distinctly to Seizures

ASN Neuro, 2019
ATP- and adenosine-mediated signaling are prominent types of glia–glia and glia–neuron interaction, with an imbalance of ATP/adenosine ratio leading to altered states of excitability, as seen in epileptic seizures.
Eliana Scemes, Libor Velíšek, Jana Velíšková   +2 more
doaj   +1 more source